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Semicarbazide hydrochloride

Semicarbazide hydrochloride
Semicarbazide hydrochloride structure
CAS No.
563-41-7
Chemical Name:
Semicarbazide hydrochloride
Synonyms
SEM;SEM·HCl;SCA-HCl;Semicarbaside;SEMICARBAZIDE HCL;Semicarbazide-13C;15N2, 98%) 100 UG/;Semicarbazide-13CHCl;CARBAMYLHYDRAZINEHCL;Semicarbazide hydroc
CBNumber:
CB8213684
Molecular Formula:
CH6ClN3O
Formula Weight:
111.53
MOL File:
563-41-7.mol

Semicarbazide hydrochloride Properties

Melting point:
175-177 °C (dec.)(lit.)
Density 
1.2908 (rough estimate)
refractive index 
1.4480 (estimate)
storage temp. 
Store at +15°C to +25°C.
solubility 
H2O: 0.1 g/mL at 20 °C, clear, colorless
form 
Crystalline Powder and/or Chunks
color 
White
PH
1.5 (100g/l, H2O, 20℃)
Water Solubility 
100 g/L (15 ºC)
Merck 
14,8444
BRN 
3593642
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
XHQYBDSXTDXSHY-UHFFFAOYSA-N
CAS DataBase Reference
563-41-7(CAS DataBase Reference)
FDA UNII
34854VG84B
IARC
3 (Vol. 12, Sup 7) 1987
EPA Substance Registry System
Semicarbazide hydrochloride (563-41-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P301+P310-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Hazard Codes  Xn,T
Risk Statements  22-40-36/38-25-45-23/24/25
Safety Statements  24/25-22-45-53
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  VT3500000
TSCA  Yes
HS Code  2928 00 90
HazardClass  6.1
PackingGroup  III
Toxicity LD50 orally in Rabbit: 123 mg/kg
NFPA 704
0
3 0

Semicarbazide hydrochloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18369 Semicarbazide hydrochloride for synthesis 563-41-7 100 g $27.47 2021-03-22 Buy
Sigma-Aldrich 84940 Semicarbazide hydrochloride purum p.a., ≥98.0% (AT) 563-41-7 100g $27.5 2021-03-22 Buy
Sigma-Aldrich 33656 Semicarbazide hydrochloride VETRANAL , analytical standard 563-41-7 100mg-r $69.2 2020-08-18 Buy
Sigma-Aldrich 33656 Semicarbazide hydrochloride VETRANAL?, analytical standard 563-41-7 100 mg $71.4 2021-03-22 Buy
Sigma-Aldrich 8.18369 Semicarbazide hydrochloride for synthesis 563-41-7 500 g $106.37 2021-03-22 Buy

Semicarbazide hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Chemical Properties

Semicarbazide hydrochloride is a white crystalline solid.

Uses

Inhibitor of enzyme. Hypotensive

Uses

A metabolite of Nitrofuran.

Hazard

Toxic by ingestion. Questionable carcino- gen.

Health Hazard

Semicarbazide hydrochloride is a chemical reagent, and an indicator for its metabolic parent nitrofurazone, a veterinary drug that has been banned for use in livestock production in the European Union and the U.S. amongst other jurisdictions.
After Semicarbazide hydrochloride ingestion, experimental animals have developed tremors, ataxia, equilibrium difficulties, and convulsions. Its proposed mechanism of action is by binding to cytosine residues in RNA, to deoxycytosine residues in DNA and to cytosine and deoxycytosine nucleosides.
Semicarbazide hydrochloride has an oral LD50 of 225mg/kg in mice and 123 mg/kg in the rat. Some studies suggest that Semicarbazide hydrochloride is a mutagen, an animal carcinogen and a teratogen.
Due to the lack of data in humans and overall limited evidence of carcinogenicity in animals, semicarbazide hydrochloride was classified as an IARC Group 3 agent: not classifiable as to its carcinogenicity to humans. Due to its equivocal carcinogenic and mutagenic properties, when handling Semicarbazide hydrochloride and animals treated with Semicarbazide hydrochloride, it is imperative to take caution and adhere to the following guidelines to minimize exposure and the effects of exposure during normal and emergency situations.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl

Potential Exposure

This material is used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic freezing/melting points. Also used in isolation of hormones and certain fractions from essential oils.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise the salt from aqueous 75% EtOH and dry it under vacuum over CaSO4. Alternatively crystallise it from a mixture of 3.6 mole % MeOH and 6.4 mole % of water. [Kovach et al. J Am Chem Soc 107 7360 1985.] IR: 700, 3500 cm-1 [Ingersoll et al. Org Synth Coll Vol I 485 1941, Davison & Christie J Chem Soc 3389 1955, Thiele & Stange Chem Ber 27 33 1894, pK: Bartlett J Am Chem Soc 54 2853 1923]. The free base crystallises as prisms from absolute EtOH, m 96o. [Curtius & Heidenreich Chem Ber 27 55 1894, Beilstein 3 IV 177.] TOXIC ORALLY, possible CARCINOGEN and TERATOGEN.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May ignite combustible materials (wood, oil, paper).

Semicarbazide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Semicarbazide hydrochloride Suppliers

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View Lastest Price from Semicarbazide hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-26 Semicarbazide hydrochloride
563-41-7
US $1.90 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-08-25 Semicarbazide hydrochloride
563-41-7
US $1.00 / KG 1KG 98%min 10T Henan Xiangtong Chemical Co., Ltd.
2021-07-13 Semicarbazide hydrochloride
563-41-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Semicarbazide hydrochloride Spectrum


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