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NELFINAVIR

NELFINAVIR
NELFINAVIR structure
CAS No.
159989-64-7
Chemical Name:
NELFINAVIR
Synonyms
AG 1341;nefinavir;NELFINAVIR;NELFINAVIR-12;8a-beta))-a-bet;NELFINAVIR USP/EP/BP;Nelfinavir Regeoisomer;AG 1341; AG-1341; AG1341;Nelfinavir & Nelfinavir Mesylate;3-isoquinolinecarboxamide,n-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hy
CBNumber:
CB8213806
Molecular Formula:
C32H45N3O4S
Formula Weight:
567.78
MOL File:
159989-64-7.mol

NELFINAVIR Properties

Melting point:
185-186 °C
Boiling point:
786.8±60.0 °C(Predicted)
alpha 
D -119.23° (c = 0.26 in methanol)
Density 
1.22±0.1 g/cm3(Predicted)
pka
pKa1 6.0; pKa2 11.06(at 25℃)
Water Solubility 
7g/L(temperature not stated)
FDA UNII
HO3OGH5D7I

NELFINAVIR Chemical Properties,Uses,Production

Uses

Antiviral.

Definition

ChEBI: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.

Indications

Nelfinavir (Viracept) is probably the most commonly used protease inhibitor because of its low incidence of serious adverse effects. Its most common side effects are diarrhea and flatulence; these may resolve with continued use. In addition to the drugs contraindicated for use with all protease inhibitors, amiodarone, rifampin, and quinidine are contraindicated in patients taking nelfinavir.

brand name

Viracept (Agouron).

Antimicrobial activity

Nelfinavir inhibits HIV-1 and HIV-2 proteases. Bioavailability is affected to only a limited degree by combination with lowdose ritonavir.

Acquired resistance

Resistance is most frequently selected through a D30N mutation in the HIV protease. An L90M mutation also confers resistance.

Pharmaceutical Applications

A synthetic chemical formulated as the mesylate for oral administration.

Pharmacokinetics

Oral absorption: c. 70–80% (with food)
Cmax 750 mg thrice daily: c. 3–4 mg/L
1250 mg twice daily: c. 4 mg/L
Cmin 750 mg thrice daily: c. 1–3 mg/L
1250 mg twice daily: c. 0.7–2.2 mg/L
Plasma half-life: c. 3.5 h
Volume of distribution: c. 2–7 L/kg
Plasma protein binding: >98%
Absorption and distribution
Food improves the bioavailability and the drug should be administered with a light meal. The semen:plasma ratio is 0.07. It is distributed into breast milk.
Metabolism and excretion
One major and several minor oxidative metabolites are found in plasma. Most of an oral dose is recovered in feces as unchanged drug (22%) and metabolites (78%). The remainder is recovered in urine, mainly unchanged.
An increase in the area under the time–concentration curve (AUC) has been observed in patients with hepatic impairment, but specific dose recommendations have not been made.

Clinical Use

Treatment of HIV infection (in combination with other antiretroviral drugs)

Side effects

The most common adverse effect is diarrhea of mild to moderate severity. Other side effects include nausea, fatigue, vomiting and headache. It is associated with less dyslipidemia in comparison with ritonavir-boosted protease inhibitors.

Metabolism

Following oral administration, nelfinavir peak levels in plasma ranged from 0.34 mg/mL (10 mg/kg in the dog) to 1.7 mg/mL (50 mg/kg in the rat). In the dog, nelfinavir was slowly absorbed, and bioavailability was 47%. The drug appeared to be metabolized in the liver, and the major excretory route was in feces.

NELFINAVIR Preparation Products And Raw materials

Raw materials

Preparation Products


NELFINAVIR Suppliers

Global( 85)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47494 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3948 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Career Henan Chemica Co
13203830695 0371-86658258
0371-86658258 Laboratory@coreychem.com CHINA 30289 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37442 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
Dideu Industries Group Limited
029-88380327, 17691182729
service@dideu.com CHINA 29997 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 14631 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
Chembest Research Laboratories Limited 021-20908456-
021-58180499 sales@BioChemBest.com China 5948 61

View Lastest Price from NELFINAVIR manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-30 Nelfinavir
159989-64-7
US $0.01-1.00 / KG 1KG 99% 50 tons Shaanxi Dideu Medichem Co. Ltd

159989-64-7(NELFINAVIR)Related Search:


  • Nelfinavir Regeoisomer
  • N-tert-butyl-2-[2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
  • AG 1341; AG-1341; AG1341
  • 3-isoquinolinecarboxamide,n-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hy
  • 8a-beta))-a-bet
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  • Nelfinavir & Nelfinavir Mesylate
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  • 159989-64-7
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