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Ammonium 1-pyrrolidinedithiocarbamate

Ammonium 1-pyrrolidinedithiocarbamate Structure
Ammonium 1-pyrrolidinedithiocarbamate structure
CAS No.
5108-96-3
Chemical Name:
Ammonium 1-pyrrolidinedithiocarbamate
Synonyms
APDTC;APDC;AMMONIUM PYRROLIDINEDITHIOCARBAMATE;PYRROLIDINEDITHIOCARBAMATE;APCD;PYRROLIDINEDITHIOCARBAMATE AMMONIUM;AMMONIUM 1-PYRROLIDINECARBODITHIOATE;ammonium pyrrolidine-1-carbodithioate;PDTC, NH4;APDC, PDTC
CBNumber:
CB8216948
Molecular Formula:
C5H9NS2.H3N
Molecular Weight:
164.3
MDL Number:
MFCD00012720
MOL File:
5108-96-3.mol
MSDS File:
SDS
Last updated:2024-04-15 15:30:59
Request For Quotation

Ammonium 1-pyrrolidinedithiocarbamate Properties

Melting point 153-155 °C(lit.)
Density 1.117 (estimate)
refractive index 1.5300 (estimate)
storage temp. Store at +2°C to +8°C.
solubility 190g/l
form Powder/Solid
color White to off-white
PH 6-7 (50g/l, H2O, 20℃)
Water Solubility 50 g/L (20 ºC)
Sensitive Hygroscopic
BRN 3730472
Stability Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 5108-96-3(CAS DataBase Reference)
EWG's Food Scores 1
EPA Substance Registry System 1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36-37/39
WGK Germany  3
F  3
TSCA  Yes
HS Code  29339990
NFPA 704
1
2 1

Ammonium 1-pyrrolidinedithiocarbamate price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 09935 Ammonium pyrrolidinedithiocarbamate purum p.a., ≥98.0% (NT) 5108-96-3 25g $72.8 2024-03-01 Buy
Sigma-Aldrich 09935 Ammonium pyrrolidinedithiocarbamate purum p.a., ≥98.0% (NT) 5108-96-3 1kg $1360 2024-03-01 Buy
Sigma-Aldrich 8.21100 Pyrrolidine-1-dithiocarboxylic acid ammonium salt for synthesis 5108-96-3 25G $53.3 2023-06-20 Buy
Sigma-Aldrich 8.21100 Pyrrolidine-1-dithiocarboxylic acid ammonium salt for synthesis 5108-96-3 100G $194 2023-06-20 Buy
Sigma-Aldrich 1.07495 Pyrrolidine-1-dithiocarboxylic acid ammonium salt GR for analysis 5108-96-3 10g $77.5 2022-05-15 Buy
Product number Packaging Price Buy
09935 25g $72.8 Buy
09935 1kg $1360 Buy
8.21100 25G $53.3 Buy
8.21100 100G $194 Buy
1.07495 10g $77.5 Buy

Ammonium 1-pyrrolidinedithiocarbamate Chemical Properties,Uses,Production

Description

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM). At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway. PDTC (100 μM) also has antioxidant properties.

Chemical Properties

pale yellow crystalline solid

Uses

Ammonium pyrrolidinedithiocarbamate has been used:

  • to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
  • to reduce neutrophil activity in rats
  • to prevent Ca2+ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Uses

1-Pyrrolidinecarbodithioic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA;

General Description

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Purification Methods

Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.]

Ammonium 1-pyrrolidinedithiocarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

Ammonium 1-pyrrolidinedithiocarbamate Suppliers

Global( 347)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@airuikechemical.com China 994 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618740459177 sarah@tnjone.com China 893 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Hebei shuoxi biotechnology co. LTD 		+8613081092107 CHINA 968 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
airuikechemical co., ltd. 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
career henan chemical co 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Hebei shuoxi biotechnology co. LTD 		58

View Lastest Price from Ammonium 1-pyrrolidinedithiocarbamate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ammonium 1-pyrrolidinedithiocarbamate pictures 2024-04-15 Ammonium 1-pyrrolidinedithiocarbamate
5108-96-3
 US $0.00 / kg 1kg 99% 10000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
Ammonium 1-pyrrolidinedithiocarbamate pictures 2024-04-07 Ammonium 1-pyrrolidinedithiocarbamate
5108-96-3
 US $0.00-0.00 / g 1g 99.99% 20 tons airuikechemical co., ltd.
Ammonium 1-pyrrolidinedithiocarbamate pictures 2023-10-14 Ammonium 1-pyrrolidinedithiocarbamate
5108-96-3
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd

Ammonium 1-pyrrolidinedithiocarbamate Spectrum

Ammonium 1-pyrrolidinedithiocarbamate(5108-96-3)MSAmmonium 1-pyrrolidinedithiocarbamate(5108-96-3)1HNMRAmmonium 1-pyrrolidinedithiocarbamate(5108-96-3)13CNMRAmmonium 1-pyrrolidinedithiocarbamate(5108-96-3)IR1Ammonium 1-pyrrolidinedithiocarbamate(5108-96-3)IR2Ammonium 1-pyrrolidinedithiocarbamate(5108-96-3)Raman

5108-96-3(Ammonium 1-pyrrolidinedithiocarbamate)Related Search:

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Ammonium nitrate AMMONIUM Ammonium dithiocarbamate AMMONIUM CARBAMATE Ammonium 1-pyrrolidinedithiocarbamate
(2,6-DICHLORO-4-PYRIDYL)METHYL PYRROLIDINE-1-CARBODITHIOATE 2-OXO-2-(3-OXOTETRAHYDRO-1H-PYRAZOL-1-YL)ETHYL 1-PYRROLIDINECARBODITHIOATE (3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYLTHIO))PYRROLIDINYLMETHANE-1-THIONE

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