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4-(Pyridin-3-yl)pyrimidin-2-amine

4-(Pyridin-3-yl)pyrimidin-2-amine structure

CAS No.: 66521-66-2

Chemical Name:: 4-(Pyridin-3-yl)pyrimidin-2-amine

Synonyms: 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;BUTTPARK 41\09-83;)-2-pyrimidine amine;4-(3-Pyridyl)-2-pyrimidinamine;Nilotinib 3-Pyridinyl Impurity;4-(3-Pyridyl)-2-pyrimidineamine;2-Amino-4-(3-pyridyl)pyrimidine;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-Pyridinyl)-2-aminopyrimidine;2-PyriMidinaMine,4-(3-pyridinyl)-

CBNumber:: CB8228031

Molecular Formula:: C9H8N4

Molecular Weight:: 172.19

MDL Number:: MFCD01317832

MOL File:: 66521-66-2.mol

MSDS File:: SDS

Last updated:2024-01-17 10:48:25

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4-(Pyridin-3-yl)pyrimidin-2-amine Properties

Melting point	189-191 °C
Boiling point	439.9±37.0 °C(Predicted)
Density	1.259±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.76±0.10(Predicted)
color	Off-White to Pale Yellow
InChI	InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)
InChIKey	LQHQKYWYKPLKCH-UHFFFAOYSA-N
SMILES	C1(N)=NC=CC(C2=CC=CN=C2)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Risk Statements

25-20/21/22

Safety Statements

45-36/37

HS Code

29339900

NFPA 704

	0
2		0

4-(Pyridin-3-yl)pyrimidin-2-amine price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2666	4-(Pyridin-3-yl)pyrimidin-2-amine	66521-66-2	1G	$87	2024-03-01	Buy
TCI Chemical	P2666	4-(Pyridin-3-yl)pyrimidin-2-amine	66521-66-2	5G	$303	2024-03-01	Buy
TRC	P991700	4-(3-Pyridinyl)-2-pyrimidinamine	66521-66-2	500mg	$525	2021-12-16	Buy
SynQuest Laboratories	3H30-1-1J	4-(Pyridin-3-yl)pyrimidin-2-amine	66521-66-2	25g	$592	2021-12-16	Buy
Medical Isotopes, Inc.	61465	4-(3-Pyridinyl)-2-pyrimidinamine	66521-66-2	100mg	$620	2021-12-16	Buy

Product number	Packaging	Price	Buy
P2666	1G	$87	Buy
P2666	5G	$303	Buy
P991700	500mg	$525	Buy
3H30-1-1J	25g	$592	Buy
61465	100mg	$620	Buy

4-(Pyridin-3-yl)pyrimidin-2-amine Chemical Properties,Uses,Production

Chemical Properties

White to off-white or brown solid.

Uses

4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.

Synthesis

3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).

4-(Pyridin-3-yl)pyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Sodium N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester Imatinib

4-(Pyridin-3-yl)pyrimidin-2-amine Suppliers

Global( 177)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hongxiong	+undefined18915499068	Suzhouhongxiong@163.com	China	120	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4242	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

Supplier	Advantage
Hongxiong	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 4-(Pyridin-3-yl)pyrimidin-2-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-12-11	4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2021-11-22	4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2	US $0.00 / KG	1KG	99%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2020-05-21	4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2	US $0.01-1.00 / KG	1KG	99%	50 tons	Shaanxi Dideu Medichem Co. Ltd

4-(3-Pyridinyl)-2-aminopyrimidine
66521-66-2
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-(3-Pyridinyl)-2-aminopyrimidine
66521-66-2
US $0.00 / KG
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

4-(3-Pyridinyl)-2-aminopyrimidine
66521-66-2
US $0.01-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

66521-66-2(4-(Pyridin-3-yl)pyrimidin-2-amine)Related Search:

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Nilotinib N-Oxide Nilotinib Impurity 4 Benzenamine, 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)- Nilotinib 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine

3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide 3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-Benzenamine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine Imatinib

N-Desmethyl Imatinib 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE 4-METHYL-6-PYRIDIN-3-YLPYRIMIDIN-2-AMINE

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BUTTPARK 41\09-83 4-(3-PYRIDINYL)-2-PYRIMIDINAMINE 4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE 4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE 4-(3-Pyridyl)-2-pyrimidinamine 4-(3-Pyridinyl)-2-aminopyrimidine 4-(3-Pyridyl)-2-pyrimidineamine 4-(3-Pyridinyl)-2-pyrimidine amine ,97% 2-amino-4-(3-pyridinyl)-pyrimidine 4-Pyridin-3-yl-pyriMidin-2-ylaMine 2-PyriMidinaMine,4-(3-pyridinyl)- 2-Amino-4-(3-pyridyl)pyrimidine 4-(3-piridinyl)-2-pirimidine amine 4-(3-Pyridinyl)-2-pyrimidine amine, 97%, reagent grade )-2-pyrimidine amine Nilotinib 3-Pyridinyl Impurity 4-(3-Pyridinyl)-2-aminopyrimidine ISO 9001：2015 REACH 4-(3-Pyridinyl)-2-aminopyrimidineQ: What is 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the CAS Number of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the storage condition of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What are the applications of 4-(3-Pyridinyl)-2-aminopyrimidine 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE 66521-66-2 C9H8N4 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals