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1-Bromo-2,3-difluorobenzene

1-Bromo-2,3-difluorobenzene Structure
1-Bromo-2,3-difluorobenzene structure
CAS No.
38573-88-5
Chemical Name:
1-Bromo-2,3-difluorobenzene
Synonyms
2,3-DIFLUOROBROMOBENZENE;2,3-Diflurobromobenzene;2,3-DifluoroBrmorobenzene;1-Bromo-2,3-difL;1-Bromo-2,3-difluoro;Rimegepant Impurity 4;Rimegepant Impurity 33;2,3- twofluorine broMine;1-Bromo-2,3-difluobenzene;3-broMo-1,2-difluorobenzene
CBNumber:
CB8236717
Molecular Formula:
C6H3BrF2
Molecular Weight:
192.99
MDL Number:
MFCD00061136
MOL File:
38573-88-5.mol
MSDS File:
SDS
Last updated:2023-12-28 13:07:02
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1-Bromo-2,3-difluorobenzene Properties

Boiling point 234 °C (765 mmHg)
Density 1.724 g/mL at 25 °C(lit.)
refractive index n20/D 1.509(lit.)
Flash point 142 °F
storage temp. 2-8°C
form clear liquid
color Colorless to Almost colorless
Specific Gravity 1.724
InChIKey RKWWASUTWAFKHA-UHFFFAOYSA-N
CAS DataBase Reference 38573-88-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H227-H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P210e-P280a-P405-P501a-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501
Hazard Codes  Xi,F
Risk Statements  36/37/38
Safety Statements  26-36/37/39-37/39
RIDADR  1993
WGK Germany  3
Hazard Note  Flammable
HazardClass  3.2
PackingGroup  III
HS Code  29039990
NFPA 704
2
2 0

1-Bromo-2,3-difluorobenzene price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B1800 1-Bromo-2,3-difluorobenzene >98.0%(GC) 38573-88-5 1g $29 2024-03-01 Buy
TCI Chemical B1800 1-Bromo-2,3-difluorobenzene >98.0%(GC) 38573-88-5 5g $55 2024-03-01 Buy
Alfa Aesar B21585 1-Bromo-2,3-difluorobenzene, 98% 38573-88-5 1g $44.65 2024-03-01 Buy
Alfa Aesar B21585 1-Bromo-2,3-difluorobenzene, 98% 38573-88-5 5g $132.65 2024-03-01 Buy
TCI Chemical B1800 1-Bromo-2,3-difluorobenzene >98.0%(GC) 38573-88-5 25g $165 2024-03-01 Buy
Product number Packaging Price Buy
B1800 1g $29 Buy
B1800 5g $55 Buy
B21585 1g $44.65 Buy
B21585 5g $132.65 Buy
B1800 25g $165 Buy

1-Bromo-2,3-difluorobenzene Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to peach liquid

Uses

1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.

Uses

intermediate for liquid crystal and drugs

General Description

Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.

Synthesis

Add 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
synthetic method of 1-Bromo-2,3-difluorobenzeneFig The synthetic method of 1-Bromo-2,3-difluorobenzene

storage

Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

1-Bromo-2,3-difluorobenzene synthesis

3828-49-7
38573-88-5
Synthesis of 1-Bromo-2,3-difluorobenzene from 2,3-Difluorotoluene

1-Bromo-2,3-difluorobenzene Preparation Products And Raw materials

Raw materials

2,3-Difluorotoluene

Preparation Products

3-Bromo-2-fluoro-phenol 4-BROMO-2,3-DIFLUOROBENZOIC ACID 1,4-DIBROMO-2,3-DIFLUOROBENZENE 3-(4-Ethylphenyl)-1,2-difluorobenzene

1-Bromo-2,3-difluorobenzene Suppliers

Global( 406)Suppliers
Supplier Tel Email Country ProdList Advantage
China Synchem Technology Co.,Ltd.
+86-0552-4929304 +86-18055277008 wangxuhui1985@126.com China 55 55
Jinan Qinmu Fine Chemical Co.,Ltd.
+8618660799346 sales@qinmuchem.com China 1009 58
Kindchem(Nanjing)Co.,Ltd 		+86-025-025-85281586 +8618651653755 sales@kindchem.cn China 1229 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 300 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7332 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 811 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Supplier Advantage
China Synchem Technology Co.,Ltd.
55
Jinan Qinmu Fine Chemical Co.,Ltd.
58
Kindchem(Nanjing)Co.,Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

View Lastest Price from 1-Bromo-2,3-difluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-2,3-difluorobenzene pictures 2024-04-12 1-Bromo-2,3-difluorobenzene
38573-88-5
 US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
1-Bromo-2,3-difluorobenzene pictures 2024-01-02 1-Bromo-2,3-difluorobenzene
38573-88-5
 US $0.00-0.00 / kg 1kg 98% 100 Kindchem(Nanjing)Co.,Ltd
1-Bromo-2,3-difluorobenzene pictures 2023-12-26 1-Bromo-2,3-difluorobenzene
38573-88-5
 US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

1-Bromo-2,3-difluorobenzene Spectrum

1-Bromo-2,3-difluorobenzene(38573-88-5)MS1-Bromo-2,3-difluorobenzene(38573-88-5)1HNMR1-Bromo-2,3-difluorobenzene(38573-88-5)13CNMR1-Bromo-2,3-difluorobenzene(38573-88-5)IR11-Bromo-2,3-difluorobenzene(38573-88-5)Raman

38573-88-5(1-Bromo-2,3-difluorobenzene)Related Search:

4,4'-DIBROMOOCTAFLUOROBIPHENYL 1-Bromo-2,3-difluorobenzene 1,2-Dibromotetrafluorobenzene 1,4-DIBROMOTETRAFLUOROBENZENE 1-BROMO-2,3,6-TRIFLUOROBENZENE
4-BROMO-2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE 1-bromo-2,3,4,6-tetrafluorobenzene 2,3,4-Trifluorobromobenzene 1-Bromo-2,3,5-trifluorobenzene 1-BROMO-2,3,4,5-TETRAFLUOROBENZENE
4-BROMO-2,3,5,6-TETRAFLUOROBENZOIC ACID 1-BROMO-4-CHLORO-2,3,5,6-TETRAFLUOROBENZENE 1,3-DIBROMOTETRAFLUOROBENZENE Bromopentafluorobenzene 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE
4-BROMO-2,5-DIFLUOROBENZENE-1-SULFONYL CHLORIDE 1-Bromo-2,5-difluorobenzene 98%,1-Bromo-2,5-difluorobenzene98%,1-BROMO-2,5-DIFLUOROBENZENE 99.5%,1-BROMO-2,5-DIFLUOROBENZENE,2-BROMO-1,4-DIFLUOROBENZENE 3,5-Difluorochlorobenzene

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2,3- twofluorine broMine 1-Bromo-2,3-difluorobenzene 98% 1-BROMO-2,3-DIFLUOROBENZENE 1-Bromo-2,3-Difluorobenzenne 2,3-Difluorobromobenzene 98% 2,3-Difluorobromobenzene98% 1-Bromo-2,3-difluorobenzene,98% 1-Bromo-2,3-difluoro 3-broMo-1,2-difluorobenzene 1-BroMo-2,3-difluorobenzene[2,3-DifluorobroMobenzene] Benzene,1-bromo-2,3-difluoro- 1-Bromo-2,3-difulorobenzene 1-Bromo-2,3-difluorobenzene > 1-Bromo-2,3-difL 1-Bromo-2,3-difluorobenzene ISO 9001：2015 REACH 2,3-DIFLUOROBROMOBENZENE 2,3-DifluoroBrmorobenzene 2,3-Diflurobromobenzene 1-Bromo-2,3-difluobenzene Rimegepant Impurity 4 Rimegepant Impurity 33 38573-88-5 38583-88-5 Halogenated Hydrocarbons Organic Building Blocks Building Blocks Aryl C6 Miscellaneous Aryl C6 Halogenated Hydrocarbons Fluorobenzene Series Fluorobenzene Aromatic Halides (substituted) Other fluorin-contained compounds Purines 38573-88-5