ChemicalBook >> CAS DataBase List >>CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)

CAS No.
162760-96-5
Chemical Name:
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
Synonyms
N-​ethyl]​piperazinyl]​methoxyphenyl)​WAY 100635;WAY100635;cyclohexanecarboxami​WAY100635 TRIHYDROCHLORIDE;WAY-100635;WAY 100635; WAY100635;Cyclohexanecarboxamide,N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-;N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxaMide
CBNumber:
CB82448237
Molecular Formula:
C25H34N4O2
Molecular Weight:
422.56
MDL Number:
MFCD00916243
MOL File:
162760-96-5.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:11

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Properties

Melting point >145oC (dec.)
Boiling point 594.8±50.0 °C(Predicted)
Density 1.154±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Methanol (Slightly), Water (Slightly)
form Solid
pka 6.84±0.10(Predicted)
color Off-White to Pale Yellow
Stability Hygroscopic
FDA UNII 71IH826FEG

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC W498665 WAY100635 162760-96-5 250mg $215 2021-12-16 Buy
ApexBio Technology A3933 WAY-100635 162760-96-5 10mg $102 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000230 WAY-100635 TRIHYDROCHLORIDE 95.00% 162760-96-5 10MG $792 2021-12-16 Buy
DC Chemicals DC22622 WAY-100635 >98% 162760-96-5 1g $800 2021-12-16 Buy
Crysdot CD31003127 WAY-100635 98+% 162760-96-5 10mg $64 2021-12-16 Buy
Product number Packaging Price Buy
W498665 250mg $215 Buy
A3933 10mg $102 Buy
BRS0000230 10MG $792 Buy
DC22622 1g $800 Buy
CD31003127 10mg $64 Buy

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Chemical Properties,Uses,Production

Uses

WAY 100635 exhibits high affinity and efficacy at the dopamine D4 receptor (1,2,3). WAY 100635 is a potent 5-HT1A antagonist.

Definition

ChEBI: N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide is a member of piperazines.

Biological Activity

5-ht1a receptors mediate various serotonergic functions and may be implicated in various pathologies including depressive and anxiety disorders, alzheimer’s disease, and schizophrenia. way-100635 is a potential spect ligands for the 5-ht1a receptor.

in vitro

way-100635 displaced specific binding of the 5-ht1a radioligand, [3h]8-oh-dpat, to rat hippocampal membranes with a plc50 of 8.87. in functional assays, way-100635 was a potent 5-ht1a receptor antagonist, with no evidence of any 5-htia receptor agonist or partial agonist activity. in the isolated guinea-pig ileum way-100635 was a potent and, at high concentrations, an insurmountable antagonist of the 5-ht1a receptor agonist action of 5-carboxamidotryptamine, with an apparent pa 2 value (at 0.3 nm) of 9.71 [2].

in vivo

way-100635 blocked the inhibitory action of 8-oh-dpat on dorsal raphe neuronal firing in the anaesthetised rat at doses which had no inhibitory action per se. in behavioural models, way-100635 itself induced no overt behavioural changes but potently antagonised the behavioural syndrome induced by 8-oh-dpat in the rat and guinea-pig (minimum effective dose = 0.003 mg/kg s.c. and id50 = 0.01 mg/kg s.c., respectively). way-100635 also blocked the hypothermia induced by 8-oh-dpat in the mouse and rat with id50 values of 0.01 mg/kg s.c. [2].

target

5-HT1A receptor

References

[1] al hussainy r, verbeek j, van der born d, braker ah, leysen je, knol rj, booij j, herscheid jk. design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of n-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-n-(pyridin-2-yl)cyclohexanecarboxamide (way-100635) as potential spect ligands for the 5-ht1a receptor. j med chem. 2011;54(10):3480-91.
[2] forster ea, cliffe ia, bill dj, dover gm, jones d, reilly y, fletcher a. a pharmacological profile of the selective silent 5-ht1a receptor antagonist, way-100635. eur j pharmacol. 1995;281(1):81-8.

35386-24-4
162760-96-5
Synthesis of CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) from 1-(2-Methoxyphenyl)piperazine

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Preparation Products And Raw materials

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1494 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 18521732826; market@aladdin-e.com China 24835 65
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189 mychess007@163.com China 1994 55
AdooQ Bioscience CHINA 025-58849295 18951903616; info@adooq.cn China 2989 60
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Spectrum

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) CYCLOHEXANECARBOXYLIC ACID (2-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-ETHYL)-PYRIDIN-2-YL-AMIDE TRIHYDROCHLORIDE Cyclohexanecarboxamide,N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl- WAY-100635;WAY 100635; WAY100635 WAY100635 TRIHYDROCHLORIDE N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxaMide WAY 100635;WAY100635 cyclohexanecarboxami​ ethyl]​ methoxyphenyl)​ N-​ piperazinyl]​ 162760-96-5 C25H34N4O2