PPT
- CAS No.
- 263717-53-9
- Chemical Name:
- PPT
- Synonyms
- PPT;-triyl)trisphenol;Propylpyrazole Triol;1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole;1,3,5-TRIS(4-HYDROXYPHENYL)-4-PROPYL-1H-PYRAZOLE;4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol;4,4',4''-(4-PROPYL-[1H]-PYRAZOLE-1,3,5-TRIYL)TRISPHENOL;Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-;Estrogen Receptor/ERR,inhibit,Inhibitor,Propyl pyrazole triol
- CBNumber:
- CB8245076
- Molecular Formula:
- C24H22N2O3
- Molecular Weight:
- 386.44
- MDL Number:
- MFCD03453628
- MOL File:
- 263717-53-9.mol
| Melting point | 230 °C (decomp) |
|---|---|
| Boiling point | 630.0±55.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | solid |
| pka | 8.80±0.15(Predicted) |
| color | off-white |
| FDA UNII | 0T83Y6JZPF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P403+P233-P405-P501 |
| WGK Germany | 3 |
PPT price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H6036 | 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole powder, ≥98% (HPLC) | 263717-53-9 | 10mg | $259 | 2024-03-01 | Buy |
| Cayman Chemical | 10008841 | Propylpyrazole Triol ≥98% | 263717-53-9 | 1mg | $21 | 2024-03-01 | Buy |
| Cayman Chemical | 10008841 | Propylpyrazole Triol ≥98% | 263717-53-9 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 10008841 | Propylpyrazole Triol ≥98% | 263717-53-9 | 10mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 10008841 | Propylpyrazole Triol ≥98% | 263717-53-9 | 25mg | $341 | 2024-03-01 | Buy |
PPT Chemical Properties,Uses,Production
Uses
PPT is a potent and specific ERα agonist.
Definition
ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols.
General Description
Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.
Biological Activity
Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .
Biochem/physiol Actions
Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
storage
+4°C
PPT Preparation Products And Raw materials
Raw materials
Preparation Products
PPT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4388 | 65 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
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