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Bisoprolol

CAS No.
66722-44-9
Chemical Name:
Bisoprolol
Synonyms
1-(4-((2-isopropoxyethoxy)Methyl)phenoxy)-3-(isopropylaMino)propan-2-ol;Bisoprolo;Cardensiel;Bisoprolol base;Bisoprolol-d5 HeMifuMarate;Bisolo;BISOPROLOL;Bisoprolol-D5;Racemic Bisoprolol;-3-(isopropylamino)
CBNumber:
CB8245445
Molecular Formula:
C18H31NO4
Molecular Weight:
325.44
MDL Number:
MFCD00865795
MOL File:
66722-44-9.mol
Last updated:2024-03-22 11:53:02

Bisoprolol Properties

Melting point 100 °C
Boiling point 445.0±45.0 °C(Predicted)
Density 1.033±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Sparingly), Methanol (Slightly)
pka pKa 9.57(H2O(extrap) t=25±1 Iunde?ned Aratmosphere) (Uncertain)
color Yellow
Water Solubility 5.5ug/L(100 ºC)
CAS DataBase Reference 66722-44-9(CAS DataBase Reference)
FDA UNII Y41JS2NL6U
NIST Chemistry Reference Bisoprolol(66722-44-9)
ATC code C07AB07

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H362
Precautionary statements  P202-P263-P264-P270-P301+P312-P308+P313
Hazard Codes  Xn
Risk Statements  22
WGK Germany  1
RTECS  UB8380000
HazardClass  IRRITANT

Bisoprolol price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 50787 Bisoprolol analytical standard 66722-44-9 25mg $142 2024-03-01 Buy
TRC C667250 Cardensiel 66722-44-9 10mg $205 2021-12-16 Buy
TRC C667250 Cardensiel 66722-44-9 50mg $950 2021-12-16 Buy
TRC C667250 Cardensiel 66722-44-9 100mg $1660 2021-12-16 Buy
Biosynth Carbosynth FB170138 Bisoprolol 66722-44-9 10mg $160 2021-12-16 Buy
Product number Packaging Price Buy
50787 25mg $142 Buy
C667250 10mg $205 Buy
C667250 50mg $950 Buy
C667250 100mg $1660 Buy
FB170138 10mg $160 Buy

Bisoprolol Chemical Properties,Uses,Production

Cardiovascular drugs

Bisoprolol is successfully developed by the German Merck in 1978, in the world ,it is already the drug of choice on clinicalcommonly used to treat hypertension, angina, arrhythmias and heart failure and other cardiovascular diseases, the product is highly selective β1-adrenergic receptor blocker,it has hydrophilic and lipophilic properties,it has no intrinsic sympathomimetic activity and membrane stability, and its negative inotropic effect is weaker.It has two β receptor binding sites with ultra-high affinity and high affinity ,its drug action is extremely powerful,it is 7 to 10 times stronger than atenolol and metoprolol . It has highly β1 receptor selectivity, selective research about model complex β1/β2 finds out that: propranolol is 1/3,atenolol is 20/1 , bisoprolol is 60/1. Another study compares the β1/β2 selectivity of metoprolol and bisoprolol, the results show that the former is 74/1,the latter is 119/1. Like other β-blockers, bisoprolol by blocking heartβ1 receptors, and inhibiting the renin-angiotensin system, plays a role in the treatment of hypertension, angina, arrhythmia. Recent studies indicate that substance P has effect on dilating the blood vessels to reduce the role of peripheral resistance, content of substance P in patients with hypertension decreases significantly,there is a significant rebound of substance P while there is a decrease in blood pressure after the treatment of bisoprolol, which may be one of the possible mechanisms of antihypertension . Another study shows that bisoprolol can not only decrease the blood pressure, but can also improve diastolic function; it has no adverse effects on blood sugar, blood lipids , conclusion in diabetics is also like this . It is mainly used to treat supraventricular tachycardia, atrial fibrillation, ventricular premature contraction, coronary heart disease, angina, mild to moderate hypertension, it is also used in heart failure caused by dilated cardiomyopathy and ischemic heart disease.
Oral F is up to 88%. Tmax is 1.5~3 h. PPB is 30%. Plasma clearance T1/2 is 10~12 h. The one dose effect can be maintained for 24 h. Because its hydrophilic character is equal to lipophilic character, its adverse reactions on central nervous system are lighter than metoprolol with lipophilic character,and its adverse reactions on renal function is smaller compared withatenolol with hydrophilic character . Bisoprolol have two equal clearance ways ,half of it is metabolized to the non-active substances in the liver , the other half is excreted in the form of the prototype by the kidneys. [Note and taboos]it is similar to atenolol.
The above information is edited by the chemicalbook of Tian Ye.

Uses

It is used for the treatment of cardiovascular and cerebrovascular diseases.

Category

Toxic Substances

Toxicity grading

Middle toxic

Acute toxicity

Intravenous-Mouse LD50: 164 mg/kg.

Flammability hazard characteristics

Combustible; combustion produces toxic nitrogen oxide gases.

Storage Characteristics

Ventilated, low-temperature ,dry storeroom.

Extinguishing agent

Water, dry powder, foam, sand.

Chemical Properties

Yellow Oil

Uses

A selective a-adrenergic blocker. Used as an antihypertensive

Uses

Cardensiel is an intermediate in the synthesis of 3,3''-(Isopropylazanediyl)bis(1-(4-((2-isopropoxyethoxy)methyl)phenoxy)propan-2-ol) (I824005), which is an impurtiy of Bisoprolol (B510500), a selective β-adrenergic blocker. Used as an antihypertensive.

Definition

ChEBI: Bisoprolol is a secondary alcohol and a secondary amine. It has a role as an antihypertensive agent, a beta-adrenergic antagonist, an anti-arrhythmia drug and a sympatholytic agent.

Enzyme inhibitor

This oral cardiospecific β-blocker (FWfree-base = 325.45 g/mol; CAS 66722- 44-9; IUPAC: (RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3- (isopropylamino)propan-2-ol), also named Zebeta? (oral tablets as fumarate salt), selectively targets β1-adrenergic receptors, blocking epinephrine stimulation of β1-adrenoreceptors that are concentrated in the heart muscle cells and heart conduction tissue as well as kidney juxtaglomerular cells. Bisoprolol is used to treat hypertension, coronary heart disease, arrhythmias, ischemic heart diseases, and myocardial infarction after the acute event. Given such versatility, bisoprolol is understandably included in the World Health Organization's List of Essential Medicines. Pharmacokinetics: Bioavailability > 90%; Hepatic metabolism (50%) by CYP2D6 and CYP3A4; Biological t1/2 = 10-12 hours.

Bisoprolol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 114)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 951 58
Henan Tianfu Chemical Co.,Ltd.
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career henan chemical co
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SIMAGCHEM CORP
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ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23556 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58

View Lastest Price from Bisoprolol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bisoprolol pictures 2024-03-28 Bisoprolol
66722-44-9
US $30.00 / kg 1kg 98% 2000kg hebei hongtan Biotechnology Co., Ltd
Bisoprolol pictures 2024-01-16 Bisoprolol
66722-44-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Bisoprolol pictures 2019-07-06 Bisoprolol
66722-44-9
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Bisoprolol pictures
  • Bisoprolol
    66722-44-9
  • US $30.00 / kg
  • 98%
  • hebei hongtan Biotechnology Co., Ltd
  • Bisoprolol pictures
  • Bisoprolol
    66722-44-9
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Bisoprolol pictures
  • Bisoprolol
    66722-44-9
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co
1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol (R)-1-(Isopropylamino)-3-[4-(2-isopropoxyethoxymethyl)phenoxy]-2-propanol (R)-1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol 1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propanol 1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol 1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-( isopropylamino)-2-propanol fumaric acid salt 1-(4-((2-Isopropoxyethoxy) -3-(isopropylamino) BISOPROLOL 2-PROPANOL, 1-[4-[[2-(1-METHYLETHOXY)ETHOXY]METHYL]PHENOXY]-3-[(1-METHYLETHYL)AMINO]- Bisoprolol(Hemifumalate) 1-[4-[2-(1-Methylethoxy)ethoxymethyl]phenoxy]-3-(1-methylethylamino)propan-2-ol Bisoprolol-D5 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol-d5 (S)-1-(Isopropylamino)-3-[4-(2-isopropoxyethoxymethyl)phenoxy]-2-propanol (S)-1-(Isopropylamino)-3-[4-[(2-isopropoxyethoxy)methyl]phenoxy]-2-propanol (S)-1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol 1-(p-2-Isopropoxyethoxymethylphenoxy)-3-isopropylaminopropan-2-ol Racemic Bisoprolol 66722-44-9 Bisoprolol Bisoprolol D5 FumarateQ: What is Bisoprolol D5 Fumarate Q: What is the CAS Number of Bisoprolol D5 Fumarate Q: What is the storage condition of Bisoprolol D5 Fumarate Q: What are the applications of Bisoprolol D5 Fumarate BisoprololQ: What is Bisoprolol Q: What is the CAS Number of Bisoprolol Q: What is the storage condition of Bisoprolol Q: What are the applications of Bisoprolol 1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propa... Bisoprolol USP/EP/BP 1-(propan-2-ylamino)-3-[2-(1-propan-2-yloxyethoxymethyl)phenoxy]-2-propanol Bisolo Bisoprolol-d5 HeMifuMarate 1-(4-((2-isopropoxyethoxy)Methyl)phenoxy)-3-(isopropylaMino)propan-2-ol Bisoprolo Bisoprolol base Cardensiel Trimethoprim Impurity 52 (RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol 66722-44-9 C18H31NO4 C18H26D5NO4 C18H26NO4D5 Isotope Labelled Compounds API Intermediates & Fine Chemicals Isotope Labeled Compounds Pharmaceuticals