1-METHYLCYCLOPROPANE-1-CARBAMIDE
- CAS No.
- 15910-91-5
- Chemical Name:
- 1-METHYLCYCLOPROPANE-1-CARBAMIDE
- Synonyms
- 1-MethylcyclopropanecarboxaMide;1-METHYLCYCLOPROPANE-1-CARBAMIDE;Cyclopropanecarboxamide, 1-methyl-;1-Methyl-cyclopropanecarboxylic acid amide
- CBNumber:
- CB82465308
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MDL Number:
- MFCD11845570
- MOL File:
- 15910-91-5.mol
| Product description | Number | Pack Size | Price |
| 1-Methylcyclopropanecarboxamide | M479040 | 1mg | $45 |
| 1-METHYLCYCLOPROPANE-1-CARBAMIDE 95.00% | CHM0097911 | 5MG | $499.93 |
| 1-Methylcyclopropanecarboxamide 97% | 128702 | 1g | $1012 |
| 1-Methylcyclopropanecarboxamide 95% | O34284 | 5G | $985 |
| 1-Methylcyclopropanecarboxamide 98% | CD13021489 | 1g | $294 |
1-METHYLCYCLOPROPANE-1-CARBAMIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M479040 | 1-Methylcyclopropanecarboxamide | 15910-91-5 | 1mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0097911 | 1-METHYLCYCLOPROPANE-1-CARBAMIDE 95.00% | 15910-91-5 | 5MG | $499.93 | 2021-12-16 | Buy |
| Matrix Scientific | 128702 | 1-Methylcyclopropanecarboxamide 97% | 15910-91-5 | 1g | $1012 | 2021-12-16 | Buy |
| ACHEMBLOCK | O34284 | 1-Methylcyclopropanecarboxamide 95% | 15910-91-5 | 5G | $985 | 2021-12-16 | Buy |
| Crysdot | CD13021489 | 1-Methylcyclopropanecarboxamide 98% | 15910-91-5 | 1g | $294 | 2021-12-16 | Buy |
1-METHYLCYCLOPROPANE-1-CARBAMIDE Chemical Properties,Uses,Production
Synthesis
6914-76-7
15910-91-5
1-Methylcyclopropanecarboxamide was synthesized as follows: 1. In a 1-L four-neck flask equipped with a magnetic stirrer, a dosing funnel, and a nitrogen inlet connected to a water scrubber, a 77.7 wt% toluene solution of 1-methylcyclopropanecarboxylic acid (185.66 g of the solution, containing approximately 144.24 g of 1-methylcyclopropanecarboxylic acid, 1.44 mol) and additional toluene (42 mL) were added. 2. The solution was heated to 45 °C and thionyl chloride (116 mL, 1.58 mol, 1.1 eq.) was added slowly and dropwise over a period of 1 hour. Gas escape and mild heat absorption were observed during the dropwise addition. 3. After the dropwise addition was completed, the reaction mixture was warmed to 80 °C and maintained for 5 hours until GC analysis showed complete consumption of 1-methylcyclopropanecarboxylic acid. 4. In another 2-L three-necked flask equipped with a mechanical stirrer and addition funnel, 28% ammonium hydroxide solution (390 mL, 5.76 mol, 4 eq.) was added. 5. The above thionyl chloride-treated reaction mixture was transferred to a charging funnel and the original reaction flask was washed with a small amount of toluene. 6. The ammonium hydroxide solution was cooled in an ice-acetone bath and the contents of the addition funnel were slowly added over a period of 1 hr, controlling the reaction temperature to no more than 25 °C. The contents of the addition funnel were then mixed with the ammonium hydroxide solution in an ice-acetone bath. 7. After completion of the addition, the mixture was further cooled to 0-5 °C and kept in an ice-water bath for 1 hour. 8. The precipitated 1-methylcyclopropanecarboxamide was collected by filtration, washed with ice water and dried over air to give a white solid product 119.4 g (84% yield) with a melting point of 144-145°C. 1H NMR (DMSO) δ: 7.03 (bs, 1H), 6.83 (bs, 1H), 1.19 (s, 3H), 0.89 (m, 2H), 0.45 (m, 2H).
References
[1] Journal of the American Chemical Society, 1961, vol. 83, p. 2719 - 2724
[2] Journal of Organic Chemistry, 1989, vol. 54, # 8, p. 1815 - 1820
[3] Patent: US2002/16493, 2002, A1
[4] Patent: US2012/22039, 2012, A1. Location in patent: Page/Page column 64
[5] Patent: US2014/275080, 2014, A1. Location in patent: Paragraph 0385
1-METHYLCYCLOPROPANE-1-CARBAMIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
1-METHYLCYCLOPROPANE-1-CARBAMIDE Suppliers
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