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Andarine

Selective Androgen Receptor Modulator Clinical Application Biological activity In vitro In vivo Characteristics
Andarine
Andarine structure
CAS No.
401900-40-1
Chemical Name:
Andarine
Synonyms
GTx007;GTx-007;sarM s4;MK-2866;Andarine;Ostarine;Andarine(S4);S-4(Andarine );Andarine, >=99%;Andarine,GTK-007
CBNumber:
CB82473534
Molecular Formula:
C19H14F3N3O3
Formula Weight:
389.3279696
MOL File:
401900-40-1.mol

Andarine Properties

Melting point:
70-74℃
Boiling point:
698.7±55.0 °C(Predicted)
Density 
1.47
storage temp. 
Refrigerator
pka
12.13±0.29(Predicted)
form 
neat
BRN 
9666695
InChIKey
YVXVTLGIDOACBJ-SFHVURJKSA-N
FDA UNII
7UT2HAH49H
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3

Andarine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 78986 (S)-3-(4-Acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide analytical standard 401900-40-1 25mg $179 2019-12-02 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 5mg $35 2020-06-24 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 10mg $67 2020-06-24 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 25mg $149 2020-06-24 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 50mg $263 2020-06-24 Buy

Andarine Chemical Properties,Uses,Production

Selective Androgen Receptor Modulator

Andarine (MK-2866), as the arylpropionamide derivate, has been developed in pharmaceutical industry as a new class of therapeutics called Selective Androgen Receptor Modulator (SARM, either agonists or antagonists at particular androgen receptors) with specific selectivity for particular tissues and organs, that could substitute the synthetic anabolic drugs used in medical treatments.

Clinical Application

The pharmacological activity of andarine suggest the great potential of andarine in the development of the clinically available SARMs, which offers unique therapeutic advantages over their steroidal counterparts and an exciting opportunity to differentially regulate the androgen effects in various target tissues, thus minimizing the interference to normal. Thus, andarine has promising in advanced clinical trials that aim to treat age-related maladies and to counteract symptoms of severe diseases such as sarcopenia and cancer cachexia.
However, andarine may be misused in sports where athletes and/or their handlers may seek to gain unfair advantage. Therefore, andarine as agonist is prohibited for use by the International Federation of Horseracing Authorities and the World Anti-Doping Agency.

Biological activity

Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.

In vitro

In vitro, Andarine binds to androgen receptors with high affinity with Ki of 4 nM. Moreover, 10 nM Andarine stimulated the transcription adjusted by androgen receptor, up to 93%.

In vivo

In vivo, Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.

Characteristics

Andarine is a selective non-steroidal androgen receptor (AR) agonist.

Chemical Properties

Pale Yellow Solid

Uses

It is a potent and tissue-selective androgen receptor modulator (SARM)

Andarine Preparation Products And Raw materials

Raw materials

Preparation Products


Andarine Suppliers

Global( 123)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 293 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 890 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58
Hebei Huanhao Biotechnology Co., Ltd.
+8618034552304
86-0311-83975816 cathylee@hbhuanhao.com CHINA 817 58

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View Lastest Price from Andarine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Andarine S-4
401900-40-1
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-09-26 Manufacturers wholesale Andarine S4/S-4 with best price and high quality CAS NO.401900-40-1
401900-40-1
US $1.20-1.00 / G 100KG 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd
2018-10-10 Sarm powder CAS 401900-40-1 Andarine S4 CAS NO.401900-40-1
401900-40-1
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd

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