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Andarine

Selective Androgen Receptor Modulator Clinical Application Biological activity In vitro In vivo Characteristics
Andarine
Andarine structure
CAS No.
401900-40-1
Chemical Name:
Andarine
Synonyms
CS-418;GTx007;GTx-007;MK-2866;sarM s4;Ostarine;Andarine;Ostarine S4;Andarine(S4);Sarms mk 2866
CBNumber:
CB82473534
Molecular Formula:
C19H18F3N3O6
Formula Weight:
441.36
MOL File:
401900-40-1.mol

Andarine Properties

Melting point:
70-74℃
Boiling point:
698.7±55.0 °C(Predicted)
Density 
1.47
storage temp. 
Refrigerator
form 
neat
pka
12.13±0.29(Predicted)
BRN 
9666695
InChIKey
YVXVTLGIDOACBJ-SFHVURJKSA-N
FDA UNII
7UT2HAH49H
NCI Drug Dictionary
Ostarine
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3

Andarine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 78986 (S)-3-(4-Acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide analytical standard 401900-40-1 25mg $186 2020-08-18 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 5mg $35 2021-03-22 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 10mg $67 2021-03-22 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 25mg $149 2021-03-22 Buy
Cayman Chemical 18772 Andarine ≥98% 401900-40-1 50mg $263 2021-03-22 Buy

Andarine Chemical Properties,Uses,Production

Selective Androgen Receptor Modulator

Andarine (MK-2866), as the arylpropionamide derivate, has been developed in pharmaceutical industry as a new class of therapeutics called Selective Androgen Receptor Modulator (SARM, either agonists or antagonists at particular androgen receptors) with specific selectivity for particular tissues and organs, that could substitute the synthetic anabolic drugs used in medical treatments.

Clinical Application

The pharmacological activity of andarine suggest the great potential of andarine in the development of the clinically available SARMs, which offers unique therapeutic advantages over their steroidal counterparts and an exciting opportunity to differentially regulate the androgen effects in various target tissues, thus minimizing the interference to normal. Thus, andarine has promising in advanced clinical trials that aim to treat age-related maladies and to counteract symptoms of severe diseases such as sarcopenia and cancer cachexia.
However, andarine may be misused in sports where athletes and/or their handlers may seek to gain unfair advantage. Therefore, andarine as agonist is prohibited for use by the International Federation of Horseracing Authorities and the World Anti-Doping Agency.

Biological activity

Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.

In vitro

In vitro, Andarine binds to androgen receptors with high affinity with Ki of 4 nM. Moreover, 10 nM Andarine stimulated the transcription adjusted by androgen receptor, up to 93%.

In vivo

In vivo, Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.

Characteristics

Andarine is a selective non-steroidal androgen receptor (AR) agonist.

Chemical Properties

Pale Yellow Solid

Uses

It is a potent and tissue-selective androgen receptor modulator (SARM)

Andarine Preparation Products And Raw materials

Raw materials

Preparation Products


Andarine Suppliers

Global( 188)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Henghe Import and Export Trading Co. LTD
18032916000 +8618032935937
demi@hbtycoon.com CHINA 453 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 2462 58
Changzhou Xuanming Chemical Co., Ltd.
18068519287 +8618068519287
sales@xuanmingchem.com CHINA 301 58
Handan Tongyi New Material Technology Co., Ltd
+8617330042575
ty003@handantongyi.com CHINA 339 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
15327141851 027-81302090
027-81302088 2851686515@qq.com CHINA 280 58
Hebei Ruiyao Biotechnology Co. Ltd
15532235888 15632182983
031188180881 admin@ruiyaobio.com CHINA 846 58
Shijiazhuang Tongyang Import and Export Co., LTD

admin@sjztongyang.com CHINA 995 58
Wuhan Aoliqisi New Material Technology Co., Ltd.
+8613545906766
sales@whaop.com China 283 58
Wuhan wingroup Pharmaceutical Co., Ltd
0086-18062075862
0086-27-87819568 admin@whwingroup.com CHINA 2481 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58

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View Lastest Price from Andarine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-27 MK2866
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-27 Ostarine
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-27 S4/Andarine
401900-40-1
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

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