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SECURININE

SECURININE structure

CAS No.: 5610-40-2

Chemical Name:: SECURININE

Synonyms: securinin;SECURININE;Securan one;(-)-securinin;(-)-Securinin;SECURAN-11-ONE;SECURININE(RG);(-)-SECURININE;(–)-Securinine;Securinan-11-on

CBNumber:: CB8247560

Molecular Formula:: C13H15NO2

Molecular Weight:: 217.26

MDL Number:: MFCD00867422

MOL File:: 5610-40-2.mol

Last updated:2023-09-20 16:43:00

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SECURININE Properties

Melting point	140-1420C
alpha	D20 -1042° (c = 1 in alc)
Boiling point	357.82°C (rough estimate)
Density	1.30±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	1.5300 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: ≥25mg/mL
form	powder
pka	8.29±0.20(Predicted)
color	yellow
optical activity	[α]/D -980 to -1015 (C=1, MeOH)
FDA UNII	G4VS580P5E

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310-P405-P501

Hazard Codes

T,Xn

Risk Statements

23/24/25-22

Safety Statements

36/37/39-45

WGK Germany

RTECS

VS4115000

NFPA 704

	0
2		0

SECURININE price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0055	Securinine ≥98% (HPLC)	5610-40-2	25mg	$298	2024-03-01	Buy
Cayman Chemical	24902	(–)-Securinine ≥98%	5610-40-2	10mg	$81	2024-03-01	Buy
Cayman Chemical	24902	(–)-Securinine ≥98%	5610-40-2	25mg	$120	2024-03-01	Buy
Cayman Chemical	24902	(–)-Securinine ≥98%	5610-40-2	50mg	$199	2024-03-01	Buy
Cayman Chemical	24902	(–)-Securinine ≥98%	5610-40-2	100mg	$356	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0055	25mg	$298	Buy
24902	10mg	$81	Buy
24902	25mg	$120	Buy
24902	50mg	$199	Buy
24902	100mg	$356	Buy

SECURININE Chemical Properties,Uses,Production

Description

A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]²⁰_D - 1106°(CHC1₃), [α]³⁰_D - 1106°(CHC1₃) and[α]²⁰_D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.

Chemical Properties

Yellow Solid

Uses

Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.

Uses

GABAA receptor blocker, CNS stimulant

Definition

ChEBI: Securinine is a member of indolizines.

References

Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)

SECURININE Preparation Products And Raw materials

Raw materials

Preparation Products

SECURININE Suppliers

Global( 161)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28965	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Aktin Chemicals, Inc.	58
Dideu Industries Group Limited	58
Baoji Guokang Healthchem co.,ltd	58

View Lastest Price from SECURININE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-02-13	Galanthamine 5610-40-2	US $90.00 / kg	1kg	99%	80MT	Hebei baicao biology science and technology co., ltd
2021-07-29	SECURININE USP/EP/BP 5610-40-2	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
2019-07-14	SECURININE 5610-40-2	US $1.00 / KG	1KG	99%	25kg	Career Henan Chemical Co

Galanthamine
5610-40-2
US $90.00 / kg
99%
Hebei baicao biology science and technology co., ltd

SECURININE USP/EP/BP
5610-40-2
US $1.10 / g
99.9%
Dideu Industries Group Limited

SECURININE
5610-40-2
US $1.00 / KG
99%
Career Henan Chemical Co

SECURININE Spectrum

SECURININE(5610-40-2)¹HNMR

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SECURAN-11-ONE SECURININE (-)-securinin securinan-11-one securinin Securinan-11-on SECURININE(RG) (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one 1,2,3,4,10,10a-Hexahydro-10-hydroxy- (2β,7S,9S)-Securinan-11-one Securan one (-)-SECURININE Securinine, 98%, from Flueggea suffruticosa (Pall.) Baill. 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 9,10,11,11a-tetrahydro-, (6S,11aR,11bS)- (–)-Securinine SECURININE USP/EP/BP (-)-Securinin 5610-40-2 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals