SECURININE
- CAS No.
- 5610-40-2
- Chemical Name:
- SECURININE
- Synonyms
- securinin;SECURININE;Securan one;(-)-securinin;(-)-Securinin;SECURAN-11-ONE;SECURININE(RG);(-)-SECURININE;(–)-Securinine;Securinan-11-on
- CBNumber:
- CB8247560
- Molecular Formula:
- C13H15NO2
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD00867422
- MOL File:
- 5610-40-2.mol
Melting point | 140-1420C |
---|---|
alpha | D20 -1042° (c = 1 in alc) |
Boiling point | 357.82°C (rough estimate) |
Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
refractive index | 1.5300 (estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO: ≥25mg/mL |
form | powder |
pka | 8.29±0.20(Predicted) |
color | yellow |
optical activity | [α]/D -980 to -1015 (C=1, MeOH) |
FDA UNII | G4VS580P5E |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
Hazard Codes | T,Xn | |||||||||
Risk Statements | 23/24/25-22 | |||||||||
Safety Statements | 36/37/39-45 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | VS4115000 | |||||||||
NFPA 704 |
|
SECURININE price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0055 | Securinine ≥98% (HPLC) | 5610-40-2 | 25mg | $298 | 2024-03-01 | Buy |
Cayman Chemical | 24902 | (–)-Securinine ≥98% | 5610-40-2 | 10mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 24902 | (–)-Securinine ≥98% | 5610-40-2 | 25mg | $120 | 2024-03-01 | Buy |
Cayman Chemical | 24902 | (–)-Securinine ≥98% | 5610-40-2 | 50mg | $199 | 2024-03-01 | Buy |
Cayman Chemical | 24902 | (–)-Securinine ≥98% | 5610-40-2 | 100mg | $356 | 2024-03-01 | Buy |
SECURININE Chemical Properties,Uses,Production
Description
A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]20D - 1106°(CHC13), [α]30D - 1106°(CHC13) and[α]20D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.
Chemical Properties
Yellow Solid
Uses
Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.
Uses
GABAA receptor blocker, CNS stimulant
Definition
ChEBI: Securinine is a member of indolizines.
References
Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)
SECURININE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 9205 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24099 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
View Lastest Price from SECURININE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-02-13 | Galanthamine
5610-40-2
|
US $90.00 / kg | 1kg | 99% | 80MT | Hebei baicao biology science and technology co., ltd | ||
2021-07-29 | SECURININE USP/EP/BP
5610-40-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | ||
2019-07-14 | SECURININE
5610-40-2
|
US $1.00 / KG | 1KG | 99% | 25kg | Career Henan Chemical Co |
- Galanthamine
5610-40-2
- US $90.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd
- SECURININE USP/EP/BP
5610-40-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
- SECURININE
5610-40-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co