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xav-939

xav-939
xav-939 structure
CAS No.
284028-89-3
Chemical Name:
xav-939
Synonyms
XAV d;CS-300;xav-939;NVP-XAV 939;SteMolecule;XAV 939, >=98%;XAV-939;XAV 939;xav-939 USP/EP/BP;XAV 939/NVP-XAV939;2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
CBNumber:
CB82501008
Molecular Formula:
C14H11F3N2OS
Formula Weight:
312.31
MOL File:
284028-89-3.mol

xav-939 Properties

Boiling point:
429.3±55.0 °C(Predicted)
Density 
1.5
Flash point:
213.4℃
storage temp. 
room temp
solubility 
DMSO: soluble5mg/mL, clear
form 
powder
pka
0.23±0.20(Predicted)
color 
white to beige
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36
Safety Statements  26-45-26/45
RIDADR  UN 2811
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29349990
NFPA 704
1
2 0

xav-939 price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich X3004 XAV 939 ≥98% (HPLC) 284028-89-3 5mg $72.1 2021-12-16 Buy
Sigma-Aldrich X3004 XAV 939 ≥98% (HPLC) 284028-89-3 25mg $290 2021-12-16 Buy
TCI Chemical X0077 XAV 939 >98.0%(HPLC) 284028-89-3 25mg $274 2021-12-16 Buy
TCI Chemical X0077 XAV 939 >98.0%(HPLC) 284028-89-3 100mg $815 2021-12-16 Buy
Cayman Chemical 13596 XAV 939 ≥98% 284028-89-3 1mg $10 2021-12-16 Buy

xav-939 Chemical Properties,Uses,Production

Uses

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Uses

XAV939 has been used in the inhibition
  • of tankyrase in neuroblastoma cell lines
  • of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
  • of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Biochem/physiol Actions

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

xav-939 Preparation Products And Raw materials

Raw materials

Preparation Products


xav-939 Suppliers

Global( 138)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 10008 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
InvivoChem
+1-708-310-1919
708-557-7486 sales@invivochem.com United States 6398 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58

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