xav-939
- CAS No.
- 284028-89-3
- Chemical Name:
- xav-939
- Synonyms
- XAV d;CS-300;xav-939;NVP-XAV 939;SteMolecule;XAV 939, >=98%;XAV-939;XAV 939;xav-939 USP/EP/BP;XAV 939/NVP-XAV939;XAV-939 284028-89-3
- CBNumber:
- CB82501008
- Molecular Formula:
- C14H11F3N2OS
- Molecular Weight:
- 312.31
- MDL Number:
- MFCD00106866
- MOL File:
- 284028-89-3.mol
- MSDS File:
- SDS
| Boiling point | 429.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.5 |
| Flash point | 213.4℃ |
| storage temp. | room temp |
| solubility | DMSO: soluble5mg/mL, clear |
| form | powder |
| pka | 0.23±0.20(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319 | |||||||||
| Precautionary statements | P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36 | |||||||||
| Safety Statements | 26-45-26/45 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
xav-939 price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | X3004 | XAV 939 ≥98% (HPLC) | 284028-89-3 | 5mg | $86 | 2024-03-01 | Buy |
| Sigma-Aldrich | X3004 | XAV 939 ≥98% (HPLC) | 284028-89-3 | 25mg | $347 | 2024-03-01 | Buy |
| TCI Chemical | X0077 | XAV 939 >98.0%(HPLC) | 284028-89-3 | 25mg | $127 | 2024-03-01 | Buy |
| TCI Chemical | X0077 | XAV 939 >98.0%(HPLC) | 284028-89-3 | 100mg | $572 | 2023-01-07 | Buy |
| Cayman Chemical | 13596 | XAV 939 ≥98% | 284028-89-3 | 1mg | $15 | 2024-03-01 | Buy |
xav-939 Chemical Properties,Uses,Production
Description
XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).? Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1? XAV-939 robustly induces cardiomyogenesis of stem cells.2? Cell permeable
Uses
A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
Uses
XAV939 has been used in the inhibition
- of tankyrase in neuroblastoma cell lines
- of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
- of wnt signalling in human induced pluripotent stem cells (hiPSCs)
Definition
ChEBI: XAV939 is a thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group. It has a role as a tankyrase inhibitor. It is a thiopyranopyrimidine and a member of (trifluoromethyl)benzenes.
Biochem/physiol Actions
XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.
storage
Room temperature
References
1) Huang?et al. (2009),?Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; Nature,?46?614 2) Wang?et al. (2011),?Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling; Chem. Biol.,?6?192
xav-939 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29576 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |