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AZD-8055

CAS No.
1009298-09-2
Chemical Name:
AZD-8055
Synonyms
CCG 168;CS-1935;AZD-8055;AZD8055, >=98%;AZD8055,AZD-8055;AZD-8055 USP/EP/BP;Dapagliflozin Impurity 167;AZD-8055; AZD8055; AZD 8055.;AZD8055 MTOR inhibitor AZD-8055;[5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[
CBNumber:
CB82501402
Molecular Formula:
C25H31N5O4
Molecular Weight:
465.54
MDL Number:
MFCD16660191
MOL File:
1009298-09-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

AZD-8055 Properties

Melting point 204 - 207°C
Boiling point 694.3±65.0 °C(Predicted)
Density 1.248
storage temp. -20°C
solubility Soluble in DMSO (up to 30 mg/ml)
form Yellow powder.
pka 14.20±0.10(Predicted)
color Yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
FDA UNII 970JJ37FPW

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H319-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Safety Statements  24/25
HS Code  29335990
NFPA 704
0
2 0

AZD-8055 price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16978 AZD 8055 ≥98% 1009298-09-2 1mg $44 2024-03-01 Buy
Cayman Chemical 16978 AZD 8055 ≥98% 1009298-09-2 5mg $87 2024-03-01 Buy
Cayman Chemical 16978 AZD 8055 ≥98% 1009298-09-2 10mg $130 2024-03-01 Buy
Cayman Chemical 16978 AZD 8055 ≥98% 1009298-09-2 50mg $384 2024-03-01 Buy
Usbiological 003022 AZD8055 1009298-09-2 10mg $425 2021-12-16 Buy
Product number Packaging Price Buy
16978 1mg $44 Buy
16978 5mg $87 Buy
16978 10mg $130 Buy
16978 50mg $384 Buy
003022 10mg $425 Buy

AZD-8055 Chemical Properties,Uses,Production

Description

AZD8055 (1009298-09-2) is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM).1,2 ?mTOR acts as a nutrient/energy/redox sensor and a controller of protein synthesis – as such it is a very important target for cancer research.? It has been investigated as a potential chemotherapeutic for various cancers.3-7

Uses

A novel ATP-competitive inhibitor of mTOR with an IC50 of 0.8 nM.

Uses

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

Definition

ChEBI: AZD-8055 is a pyridopyrimidine that is pyrido[2,3-d]pyrimidine which is substituted at positions 2 and 4 by (3S)-3-methylmorpholin-4-yl groups and at position 5 by a 3-(hydroxymethyl)-4-methoxyphenyl group. It is an mTOR complex 1/2 (mTORC1/2) dual inhibitor [mTOR = mammalian target of rapamycin]. It has a role as a mTOR inhibitor, an apoptosis inducer and an antineoplastic agent. It is a member of benzyl alcohols, a tertiary amino compound, a pyridopyrimidine and a member of morpholines.

target

mTOR (full length)

storage

Store at -20°C

References

1) Chresta et al. (2010), AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity; Cancer Res. 70 288 2) Pike et al. (2013), Optimization of potent an selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014; Bioorg. Med. Chem. Lett. 23 1212 3) Holt et al. (2012), Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055); Cancer Res. 72 1804 4) Willems et al. (2012), The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia; Leukemia 26 1195 5) Li et al. (2013),The mTOR inhibitor AZD8055 inhibits proliferation and glycolysis in cervical cancer cells; Oncol. Lett. 5 717 6) Li et al. (2013), The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro; Biochem. Biophys. Res. Commun. 440 701 7) Hu et al. (2014), AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma; Oncol. Rep. 31 649

AZD-8055 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 191)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47464 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58

View Lastest Price from AZD-8055 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZD-8055 pictures 2019-09-02 AZD-8055
1009298-09-2
US $7.00 / KG 1KG 99% JD 495 Career Henan Chemical Co
AZD-8055 pictures 2019-07-06 AZD-8055
1009298-09-2
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • AZD-8055 pictures
  • AZD-8055
    1009298-09-2
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co
  • AZD-8055 pictures
  • AZD-8055
    1009298-09-2
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

AZD-8055 Spectrum

AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD8055, >=98% Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester (5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate [5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[ 5-[2,4-Bis[(3S)-3-Methyl-4-Morpholinyl]pyrido[2,3-d]pyriMidin-7-yl]-2-MethoxybenzeneMethanol CCG 168 AZD8055,AZD-8055 AZD-8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol (5-(2,4-Bis((S)-3-methylmorpholino)pyrido-[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD 8055 CS-1935 {5-[2,4-Bis-(3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol AZD-8055; AZD8055; AZD 8055. Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy- AZD-8055 USP/EP/BP (5-{2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol AZD8055 MTOR inhibitor AZD-8055 inhibit,AZD-8055,AZD8055,Apoptosis,mTOR,Mammalian target of Rapamycin,AZD 8055,Inhibitor,Autophagy Dapagliflozin Impurity 167 1009298-09-2 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators Akt mTOR PI3K Inhibitors PI3K/Akt/mTOR