BKM120 (NVP-BKM120, Buparlisib)
- CAS No.
- 944396-07-0
- Chemical Name:
- BKM120 (NVP-BKM120, Buparlisib)
- Synonyms
- isib;100821;CS-227;BuparL;AN-2025;Buparlisib;BKM120BASE;NVP-BKM-120;BKM120, >=98%;NVP-BKM120, BKM120
- CBNumber:
- CB82509983
- Molecular Formula:
- C18H21F3N6O2
- Molecular Weight:
- 410.39
- MDL Number:
- MFCD18251596
- MOL File:
- 944396-07-0.mol
- MSDS File:
- SDS
Melting point | 143-147°C |
---|---|
Boiling point | 645.7±65.0 °C(Predicted) |
Density | 1.382 |
storage temp. | -20°C |
solubility | Soluble in DMSO (15 mg/ml) |
form | White powder. |
pka | 5.94±0.50(Predicted) |
color | White |
Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
FDA UNII | 0ZM2Z182GD |
NCI Drug Dictionary | buparlisib |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08,GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H372-H341-H301 | |||||||||
Precautionary statements | P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
HS Code | 29349990 | |||||||||
NFPA 704 |
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BKM120 (NVP-BKM120, Buparlisib) price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 11587 | NVP-BKM120 ≥95% | 944396-07-0 | 5mg | $26 | 2024-03-01 | Buy |
Cayman Chemical | 11587 | NVP-BKM120 ≥95% | 944396-07-0 | 50mg | $141 | 2024-03-01 | Buy |
Cayman Chemical | 11587 | NVP-BKM120 ≥95% | 944396-07-0 | 1mg | $31 | 2023-06-20 | Buy |
Cayman Chemical | 11587 | NVP-BKM120 ≥95% | 944396-07-0 | 10mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 11587 | NVP-BKM120 ≥95% | 944396-07-0 | 25mg | $102 | 2024-03-01 | Buy |
BKM120 (NVP-BKM120, Buparlisib) Chemical Properties,Uses,Production
Description
Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110? = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1μM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
Uses
A selective Class I PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50s of 50-300 nM.
Uses
NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.
Definition
ChEBI: BKM120 is an aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a member of morpholines, an aminopyrimidine, an aminopyridine and an organofluorine compound.
target
p110α
References
Burger et al. (2011), Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer; ACS Med. Chem. Lett. 2 774 Maira et al. (2012), Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor; Mol. Cancer Ther. 11 317 Brachmann et al. (2012), Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations; Mol. Cancer Ther. 11 1747 Juvekar et al. (2016), Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion; Proc. Natl. Acad. Sci USA. 113 E4338
BKM120 (NVP-BKM120, Buparlisib) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13349 | 58 |
View Lastest Price from BKM120 (NVP-BKM120, Buparlisib) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-02-18 | NVP-BKM-120
944396-07-0
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | ||
2019-07-06 | BKM120 (NVP-BKM120, Buparlisib)
944396-07-0
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- NVP-BKM-120
944396-07-0
- US $0.00 / gram
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
- BKM120 (NVP-BKM120, Buparlisib)
944396-07-0
- US $2.00 / kg
- 99%
- Career Henan Chemical Co