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MK-1775

CAS No.
955365-80-7
Chemical Name:
MK-1775
Synonyms
AZD1775;CS-605;101254;MK-1775;MK-1175;MK-1755;Adavosertib);MK-1775, >=98%;MK-1775,MK1775;MK-1775, AZD1775,
CBNumber:
CB82514921
Molecular Formula:
C27H32N8O2
Molecular Weight:
500.6
MDL Number:
MFCD17215200
MOL File:
955365-80-7.mol
Last updated:2023-06-30 15:45:59

MK-1775 Properties

Melting point 179-181°C
Boiling point 723.8±70.0 °C(Predicted)
Density 1.292
storage temp. -20°C
solubility Soluble in DMSO (70 mg/ml)
form solid
pka 13.27±0.29(Predicted)
color Yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII K2T6HJX3I3
NCI Drug Dictionary adavosertib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

MK-1775 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21266 MK-1775 ≥98% 955365-80-7 5mg $44 2024-03-01 Buy
Cayman Chemical 21266 MK-1775 ≥98% 955365-80-7 10mg $78 2024-03-01 Buy
Cayman Chemical 21266 MK-1775 ≥98% 955365-80-7 25mg $172 2024-03-01 Buy
Cayman Chemical 21266 MK-1775 ≥98% 955365-80-7 50mg $278 2024-03-01 Buy
Usbiological 456305 MK 1775 955365-80-7 5mg $312 2021-12-16 Buy
Product number Packaging Price Buy
21266 5mg $44 Buy
21266 10mg $78 Buy
21266 25mg $172 Buy
21266 50mg $278 Buy
456305 5mg $312 Buy

MK-1775 Chemical Properties,Uses,Production

Description

MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.

Uses

MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

Definition

ChEBI: 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methyl-1-piperazinyl)anilino]-2-prop-2-enyl-3-pyrazolo[3,4-d]pyrimidinone is a member of piperazines.

in vitro

mk-1775 dose-dependently inhibited phosphorylation of cdc2 at tyr15 and abrogated the g2dna damage checkpoint. mk-1775 inhibited wee1 kinase in an atp-competitive manner with an ic50 value of 5.2 nmol/l in the in vitro kinase assays. compared to wee1, mk-1775 displayed 2- to 3-fold less potency against yes with the ic50value of 14 nm, 10-fold less potency against seven other kinases with >80% inhibition at 1 μm, and >100-fold selectivity over human myt 1, another kinase that inhibited cyclin-dependent kinase 1 (cdc2) by phosphorylation at an alternative site (thr14). by abrogating the dna damage checkpoint via blockade of wee1 activity in widr cells bearing mutated p53, mk-1775 treatment inhibited the basal phosphorylation of cdc2 at tyr15 (cdc2y15) with an ec50 of 49 nm, and dose-dependently suppressed gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of cdc2 and cell cycle arrest, with the ec50 of 82 nm and 81 nm, 180 nm and 163 nm, as well as 159 nm and 160 nm, respectively. in widr and h1299 cells, mk-1775 treatment (30-100 nm)showed no significant antiproliferative effects, whereas mk-1775 at 300 nm was sufficient to inhibit wee1 by >80%, displayed moderate but significant antiproliferative effects by 34.1% in widr cells and 28.4% in h1299 cells [1].

target

Wee1

storage

Store at -20°C

References

Hirai et al. (2009) Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents; Cancer Ther.?8 2992 Pan et al. (2021) A novel WEE1 pathway for replication stress responses; Plants 7 209 Guo et al. (2022) WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway; Exp. Med. 219 e20210789 Seo et al. (2021) Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer; Cancer Res. Treat. Epub ahead of print

26218-75-7
955365-80-7
Synthesis of MK-1775 from 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
Global( 235)Suppliers
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Nanjing ChemLin Chemical Industry Co., Ltd.
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Qiuxian Baitai New Material Co., LTD
+8618330912755 sale2@hbyalin.com China 1677 58

View Lastest Price from MK-1775 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK-1775 pictures 2022-01-14 MK-1775
955365-80-7
US $0.00 / KG 1KG 98.1% 100 tons Honest Joy Holdings Limited
Adavosertib pictures 2021-11-15 Adavosertib
955365-80-7
US $1.50 / g 100g 99% 500ton/Month Qiuxian Baitai New Material Co., LTD
MK-1775 pictures 2021-09-28 MK-1775
955365-80-7
US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
  • MK-1775 pictures
  • MK-1775
    955365-80-7
  • US $0.00 / KG
  • 98.1%
  • Honest Joy Holdings Limited
  • Adavosertib pictures
  • Adavosertib
    955365-80-7
  • US $1.50 / g
  • 99%
  • Qiuxian Baitai New Material Co., LTD
  • MK-1775 pictures
  • MK-1775
    955365-80-7
  • US $1.10 / g
  • 99.00%
  • Dideu Industries Group Limited

MK-1775 Spectrum

2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK-1775 MK-1775,MK1775 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775 MK 1775 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK-1775, >=98% MK-1175 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- MK-1775, AZD1775, 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H- MK1775;AZD-1775;AZD1775;AZD 1775;MK 1775 CS-605 101254 2-ALLYL-1-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-2-YL)-6-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)-1H-PYRAZO Adavosertib) 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one Adavosertib (MK-1775) MK-1775(955365-80-7) MK-1775(AZD1775,Adavosertib) AZD1775;MK-1775;MK1775 MK-1775,Adavosertib 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)pyrazolo[3,4-d]pyrimidin-3-one 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one MK-1775 ISO 9001:2015 REACH 2-Allyl-1-[6-(2-hydroxy-2-propyl)-2-pyridyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrazolo[3,4-d]pyrimidin-3(2H)-one Adavosertib (AZD-1775 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiper... AZD1775 MK-1755 AZD-1775,AZD 1775,MK1775,MK 1775,Adavosertib,Wee1,inhibit,Inhibitor 955365-80-7 Inhibitors Other APIs API