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ChemicalBook >> CAS DataBase List >>4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Structure
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one structure
CAS No.
91526-18-0
Chemical Name:
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Synonyms
DMDO-OH;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;AZATMint-D;Azilsartan Impurity 55;Azilasartan medoximil(HPLC-98.2%);4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one;1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
CBNumber:
CB82515847
Molecular Formula:
C5H6O4
Molecular Weight:
130.1
MDL Number:
MFCD12165896
MOL File:
91526-18-0.mol
Last updated:2023-11-17 10:43:46
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4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Properties

Boiling point 214℃
Density 1.367
Flash point 93℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form liquid
pka 14.54±0.10(Predicted)
color Pale yellow
InChI InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3
InChIKey JEQSUJXHFAXJOW-UHFFFAOYSA-N
SMILES O1C(C)=C(CO)OC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501
HS Code  2932990090

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC H939928 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 91526-18-0 50mg $60 2021-12-16 Buy
SynQuest Laboratories 2H25-1-2V 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 97% 91526-18-0 1g $48 2021-12-16 Buy
Apolloscientific OR927927 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96% 91526-18-0 1g $30 2021-12-16 Buy
Apolloscientific OR927927 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96% 91526-18-0 5g $110 2021-12-16 Buy
SynQuest Laboratories 2H25-1-2V 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 97% 91526-18-0 5G $176 2021-12-16 Buy
Product number Packaging Price Buy
H939928 50mg $60 Buy
2H25-1-2V 1g $48 Buy
OR927927 1g $30 Buy
OR927927 5g $110 Buy
2H25-1-2V 5G $176 Buy

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties,Uses,Production

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.

Definition

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group.

Uses

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.

Preparation

At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one synthesis

80841-78-7
91526-18-0
Synthesis of 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

4,5-Dimethyl-1,3-dioxol-2-one 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 4-forMyloxyMethyl-5-Methyl- 1,3-dioxolene-2-one 4-Bromomethyl-5-methyl-1,3-dioxol-2-one

Preparation Products

Carbonothioic acid, S-ethyl O-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl) ester

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Suppliers

Global( 231)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Verychem Science And Technology Co.Ltd
+86-86-57188162785 13606544505 lucy@verychem.com China 1001 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Supplier Advantage
Hangzhou Verychem Science And Technology Co.Ltd
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one pictures 2023-09-08 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
91526-18-0
 US $0.00 / KG Ton 1KG Ton 95%+ 2 tons/month Zhuhai Hairuide Bioscience and Technology Co., Ltd
4-(hidroximetil)-5-metil-1,3-dioxol-2-one pictures 2022-09-30 4-(hidroximetil)-5-metil-1,3-dioxol-2-one
91526-18-0
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4-(Hydroxymethyl)-5-methyl-[1,3]dioxol-2-one pictures 2022-09-15 4-(Hydroxymethyl)-5-methyl-[1,3]dioxol-2-one
91526-18-0
 US $30.00-28.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd

91526-18-0(4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one)Related Search:

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1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl- 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona 4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one 4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one 4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene AZATMint-D 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona ISO 9001：2015 REACH Azilsartan Impurity 55 Azilasartan medoximil(HPLC-98.2%) 4-(hydroxymethyl)-5-methyl-2H-1,3-dioxol-2-one 4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one DMDO-OH 4- (hydroxymethyl) -5- methyl -[1,3] dioxolane -2- one 4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one 91526-18-0 94526-18-0