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LY-2484595

LY-2484595 structure

CAS No.: 1186486-62-3

Chemical Name:: LY-2484595

Synonyms: SW-86;CS-653;SWF-86;LY-2484595;Evacetrapib;Evacetrapib, >=98%;LY-2484595 USP/EP/BP;LY-2484595 Evacetrapib;Evacetrapib (LY2484595);LY2484595; LY 2484595; LY-2484595

CBNumber:: CB82516031

Molecular Formula:: C31H36F6N6O2

Molecular Weight:: 638.65

MDL Number:

MOL File:: 1186486-62-3.mol

Last updated:2023-05-21 10:59:17

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LY-2484595 Properties

Boiling point	680.1±65.0 °C(Predicted)
Density	1.40
storage temp.	Store at -20°C
solubility	≥32.1 mg/mL in DMSO; insoluble in H2O; ≥50.4 mg/mL in EtOH with ultrasonic
pka	4.73±0.10(Predicted)
form	solid
FDA UNII	51XWV9K850

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS09
Signal word	Danger
Hazard statements	H410-H361-H400
Precautionary statements	P273-P391-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501

LY-2484595 price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23670	Evacetrapib ≥98%	1186486-62-3	5mg	$81	2024-03-01	Buy
Cayman Chemical	23670	Evacetrapib ≥98%	1186486-62-3	10mg	$152	2024-03-01	Buy
Cayman Chemical	23670	Evacetrapib ≥98%	1186486-62-3	50mg	$475	2024-03-01	Buy
Cayman Chemical	23670	Evacetrapib ≥98%	1186486-62-3	100mg	$790	2024-03-01	Buy
TRC	E945200	Evacetrapib	1186486-62-3	25mg	$250	2021-12-16	Buy

Product number	Packaging	Price	Buy
23670	5mg	$81	Buy
23670	10mg	$152	Buy
23670	50mg	$475	Buy
23670	100mg	$790	Buy
E945200	25mg	$250	Buy

LY-2484595 Chemical Properties,Uses,Production

Uses

Evacetrapib is an inhibitor of?cholesteryl ester transfer protein (CETP). CETP catalyzes the exchange of cholesteryl ester and triglyceride between lipoproteins and modulates HDL cholesterol levels in plasma. CETP inhibitors are potential compounds for treating coronary artery disease.

Definition

ChEBI: Evacetrapib is a benzazepine.

Biological Activity

evacetrapib is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) with ic50 value of 5.5nm [1].as a benzazepine-based inhibitor of cetp, evacetrapib is developed to increase hdl cholesterol for the treatment of coronary artery disease. evacetrapib is efficacious both in vitro and in vivo. the ic50 values of evacetrapib against cetp are 5.5nm and 26nm, respectively in the buffer assay using human recombinant cetp and in the plasma assay using human plasma cetp. in the animal model of human cetp/apoai double transgenic mouse line, oral administration of evacetrapib at 30mg/kg significantly inhibits the cetp activity as well as increases the level of hdl. besides that, the ed50 value of evacetrapib is less than 5mg/kg. compared to the previous inhibitors of cetp, evacetrapib has less side effects. it is found no to increase blood pressure zucker diabetic fatty rats and not to induce aldosterone or cortisol synthesis in h295r cells [1].

target

CETP

References

[1] cao g, beyer tp, zhang y, schmidt rj, chen yq, cockerham sl, zimmerman km, karathanasis sk, cannady ea, fields t, mantlo nb. evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates hdl cholesterol without inducing aldosterone or increasing blood pressure. j lipid res. 2011 dec;52(12):2169-76.

LY-2484595 Preparation Products And Raw materials

Raw materials

Preparation Products

LY-2484595 Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4022	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from LY-2484595 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-03	LY-2484595 1186486-62-3	US $1.00-2.00 / KG	1KG	95.0-99.8%	1KG;5KG 10KG; 100KG	Career Henan Chemical Co

LY-2484595
1186486-62-3
US $1.00-2.00 / KG
95.0-99.8%
Career Henan Chemical Co

LY-2484595 Spectrum

LY-2484595(1186486-62-3)¹HNMR

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1of4

LY-2484595 Evacetrapib trans-4-[[(5S)-5-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid (1S,4r)-4-(((S)-5-((3,5-bis(trifluoroMethyl)benzyl)(2-Methyl-2H-tetrazol-5-yl)aMino)-7,9-diMethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)Methyl)cyclohexanecarboxylic acid Evacetrapib (LY2484595) Cyclohexanecarboxylic acid, 4-[[(5S)-5-[[[3,5-bis(trifluoroMethyl)phenyl]Methyl](2-Methyl-2H-tetrazol-5-yl)aMino]-2,3,4,5-tetrahydro-7,9-diMethyl-1H-1-benzazepin-1-yl]Methyl]-, trans- Evacetrapib, >=98% EVACETRAPIB (LY2484595);LY2484595;LY 2484595;LY-2484595 (1S,4r)-4-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimet LY-2484595 Evacetrapib LY2484595; LY 2484595; LY-2484595 4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylicacid CS-653 LY-2484595 USP/EP/BP SWF-86 SW-86 4-trans-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid 1186486-62-3 C31H36F6N6O2 Inhibitors Inhibitor