MLN9708
- CAS No.
- 1201902-80-8
- Chemical Name:
- MLN9708
- Synonyms
- MLN9708;CS-1830;Ninlaro);MLN-9708 analog;MLN 9708 analog;MLN9708;MLN-9708;Ixazomib Citrate;Esazomide citrate;MLN9708,MLN-9708,MLN 9708;MLN 9708 - Ixazomib citrate
- CBNumber:
- CB82521079
- Molecular Formula:
- C20H23BCl2N2O9
- Molecular Weight:
- 517.12
- MDL Number:
- MFCD18251437
- MOL File:
- 1201902-80-8.mol
- MSDS File:
- SDS
| Melting point | >227°C (dec.) |
|---|---|
| Density | 1.47 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pka | 1.92±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| NCI Dictionary of Cancer Terms | ixazomib citrate |
| FDA UNII | E8R04MBQ04 |
| NCI Drug Dictionary | ixazomib citrate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
MLN9708 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18386 | MLN9708 ≥95% | 1201902-80-8 | 5mg | $60 | 2024-03-01 | Buy |
| Cayman Chemical | 18386 | MLN9708 ≥95% | 1201902-80-8 | 1mg | $43 | 2023-06-20 | Buy |
| Cayman Chemical | 18386 | MLN9708 ≥95% | 1201902-80-8 | 10mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 18386 | MLN9708 ≥95% | 1201902-80-8 | 50mg | $208 | 2024-03-01 | Buy |
| TRC | M425158 | MLN-9708 | 1201902-80-8 | 50mg | $180 | 2021-12-16 | Buy |
MLN9708 Chemical Properties,Uses,Production
Description
Ixazomib citrate is a proteasome inhibitor prodrug for the treatment of multiple myeloma in patients who have received at least one prior therapy in combination with lenalidomide and dexamethasone. The drug was developed by Takeda and reversibly inhibits the protein proteasome subunit β type-5, which is part of the 20S proteasome complex. Ixazomib citrate (XXIV) is hydrolyzed quickly in vivo to give the biologically active compound ixazomib, which presumably is the corresponding boronic acid variant of XXIV.
Uses
MLN-9708 is a novel proteasome?inhibitor.
Clinical Use
Highly selective and reversible proteasome inhibitor:
Treatment of multiple myeloma in combination with
lenalidomide and dexamethasone
Synthesis
The structure of ixazomib citrate is particularly interesting in that it is one of the relatively few marketed drugs which feature a boron atom within its structure (others of note being the oncology medication bortezomib and the antifungal drug tavaborole13). The ostensible scale synthetic approach began with reaction of commercial 2,5-dichlorobenzoyl chloride (188) with glycine in aqueous NaOH to furnish amide 189 in 97% yield as a white crystalline solid. Acid 189 was then coupled with commercially available 1,3,2-benzodioxaborolane 190 in the presence of TBTU and DIPEA in DMF at low temperature to give diamide 191, which was used without purification for the next step. Borane 191 was then deprotected with (2-methylpropyl)boronic acid in methanolic HCl to provide trimer 192 in 74% as a white solid. Finally, boroxin 192 was reacted with citric acid in EtOAc to dissociate the trimer, resulting in ixazomib citrate (XXIV) in 88% yield as a crystalline solid.
MLN9708 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
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