Plerixafor
- CAS No.
- 1246819-87-3
- Chemical Name:
- Plerixafor
- Synonyms
- Plerixafor-d4;[2H4]-Plerixafor;Paclobutrazol Impurity 6
- CBNumber:
- CB82545583
- Molecular Formula:
- C28H54N8
- Molecular Weight:
- 502.78196
- MDL Number:
- MFCD19705148
- MOL File:
- 1246819-87-3.mol
Plerixafor price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26490 | Plerixafor-d4 | 1246819-87-3 | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 26490 | Plerixafor-d4 | 1246819-87-3 | 1mg | $230 | 2024-03-01 | Buy |
| TRC | P580502 | Plerixafor-d4 | 1246819-87-3 | 1mg | $150 | 2021-12-16 | Buy |
| Usbiological | 019845 | Plerixafor-d4 | 1246819-87-3 | 2.5mg | $418 | 2021-12-16 | Buy |
| TRC | P580502 | Plerixafor-d4 | 1246819-87-3 | 10mg | $1190 | 2021-12-16 | Buy |
Plerixafor Chemical Properties,Uses,Production
Description
Plerixafor-d4 is intended for use as an internal standard for the quantification of plerixafor by GC- or LC-MS. Plerixafor is a partial antagonist of chemokine receptor 4 (CXCR4) with IC50 values ranging from 0.02 to 0.13 μg/ml for inhibiting calcium flux in peripheral blood mononuclear cells (PBMCs), various types of T cells, and mouse lymphocytic leukemia cells. It is selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 μg/ml). Plerixafor decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 μg/ml). It rapidly mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation alone and, with a synergistic effect, when used in combination with G-CSF. Plerixafor also increases T cell trafficking in mouse blood, spleen, and central nervous system. Plerixafor (1.25 mg/kg twice per day) decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis.
Chemical Properties
Off-White Solid
Uses
Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin''s lymphoma (NHL) and multiple myeloma (MM).
Uses
Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transpl antation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).
Plerixafor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | 12345678910 | nanfengdrug@163.com | China | 15323 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 13698 | 58 |