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PTEROIC ACID

PTEROIC ACID Structure
PTEROIC ACID structure
CAS No.
119-24-4
Chemical Name:
PTEROIC ACID
Synonyms
4-(((2-AMino-4-oxo-3,4-dihydropteridin-6-yl)Methyl)aMino)benzoic acid;Pyrofolic acid;4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoic acid;NSC 14972;PTEROIC ACID;Butterfly acid;Pteroic Acid (>Pteroic acid >=93%;Pteroic Acid (>85%);Folic acid iMpurity D
CBNumber:
CB8254618
Molecular Formula:
C14H12N6O3
Molecular Weight:
312.28
MDL Number:
MFCD27967230
MOL File:
119-24-4.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:32
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PTEROIC ACID Properties

Melting point >400℃
Boiling point 610.0±65.0 °C(Predicted)
Density 1.69
storage temp. 2-8°C
solubility Aqueous Base (Slightly), DMSO (Slightly)
pka 4.65±0.10(Predicted)
color Light Yellow to Brown
FDA UNII 8258W48TBZ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P261-P271
WGK Germany  3
HS Code  2933599590

PTEROIC ACID price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P1781 Pteroic acid ≥93% 119-24-4 25mg $81.7 2024-03-01 Buy
Sigma-Aldrich P1781 Pteroic acid ≥93% 119-24-4 50mg $131 2024-03-01 Buy
Sigma-Aldrich PHR2002 Folic Acid Impurity D Pharmaceutical Secondary Standard; Certified Reference Material 119-24-4 100mg $647 2024-03-01 Buy
Sigma-Aldrich Y0001243 Folic acid impurity D European Pharmacopoeia (EP) Reference Standard 119-24-4 y0001243 $220 2024-03-01 Buy
Sigma-Aldrich P1781 Pteroic acid ≥93% 119-24-4 100mg $255 2024-03-01 Buy
Product number Packaging Price Buy
P1781 25mg $81.7 Buy
P1781 50mg $131 Buy
PHR2002 100mg $647 Buy
Y0001243 y0001243 $220 Buy
P1781 100mg $255 Buy

PTEROIC ACID Chemical Properties,Uses,Production

Uses

Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.

Uses

Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase.

Definition

ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid.

General Description

Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Enzyme inhibitor

This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.

Purification Methods

Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]

PTEROIC ACID Preparation Products And Raw materials

Raw materials

AcetaMide, 2,2,2-trifluoro-N-(4-iodophenyl)- N10-Trifluoroacetyl Pyrofolic Acid 4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- CHEMBRDG-BB 5276151
Folic acid 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE 4-Aminobenzoic acid

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Preparation Products

Benzoic acid, 4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester

PTEROIC ACID Suppliers

Global( 262)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
AB PharmaTech,LLC 		323-480-4688 United States 989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58
Biochempartner 		58
Accela ChemBio Inc. 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from PTEROIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pteroic Acid pictures 2021-12-14 Pteroic Acid
119-24-4
 US $10.00 / g/Bag 10g 99 100KG Wuhan Demeikai Biotechnology Co., Ltd
Pteroic Acid pictures 2021-05-08 Pteroic Acid
119-24-4
 US $100.00 / KG 1KG 99% 1000t Hebei Minshang Biological Technology Co. LTD
PTEROIC ACID pictures 2019-07-06 PTEROIC ACID
119-24-4
 US $2.00 / KG 1KG 98% 1ton Career Henan Chemical Co
  • Pteroic Acid pictures
  • Pteroic Acid
    119-24-4
  • US $10.00 / g/Bag
  • 99
  • Wuhan Demeikai Biotechnology Co., Ltd
  • Pteroic Acid pictures
  • Pteroic Acid
    119-24-4
  • US $100.00 / KG
  • 99%
  • Hebei Minshang Biological Technology Co. LTD

119-24-4(PTEROIC ACID)Related Search:

(2S)-2-[[4-[Bis[(2-aMino-4-oxo-1,4-dihydropteridin-6-yl)Methyl]aMino]benzoyl]aMino]pentanedioic Acid 2-Amino-7-(chloromethyl)pteridin-4(1H)-one 2-Amino-4-hydroxy-1H-pteridine Erinacine A Erinacin A 5-formyl-5,6,7,8-tetrahydropteroic acid
2-Amino-6-(chloromethyl)-4(3H)-pteridinone Folitixorin (Mixture of DiastereoMers) N-(4-aminobenzoyl)- D-Glutamic acid Folic acid 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers)
Folic Acid Impurity C N-(p-Aminobenzoyl)glutamic acid folic acid 5-Methyltetrahydrofolic acid 10-Formylfolic Acid
Folinic acid 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE L-Tetrahydrofolic Acid

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4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid 4-[(2-azanyl-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid 4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid 4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoic Acid NSC 14972 p-[(2-AMino-4-hydroxy-6-pteridylMethyl)aMino]benzoic Acid Benzoic acid, 4-[[(2-aMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]aMino]- Folic acid iMpurity D Folic acid iMpurity D Pteroic acid Pteroic Acid (>85%) Pteroic acid >=93% NSC 14972 4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid 4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl) PTEROIC ACID p-((2-amino-4-hydroxypteridin-6-yl)methylamino)benzoic acid PTEROIC ACID HYDRATE, 90% Folic acid impurity DQ: What is Folic acid impurity D Q: What is the CAS Number of Folic acid impurity D Q: What is the storage condition of Folic acid impurity D Q: What are the applications of Folic acid impurity D 4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid(119-24-4) 4-[(2-amino-4-oxo-8H-pteridin-6-yl)methylamino]benzoic acid Folic Acid Impurity 6（Folic Acid EP Impurity D） Methotrexate EP Impurity D Desmethyl Impurity Pteroic Acid (> 4-[[(2-Amino-4-oxo-1,4-dihydropteri Folic acid impurity D CRS 4-(((2-amino-4-hydroxypteridin-6-yl) Methotrexate EP Impurity D N-Desmethyl Impurity Pteroic acid(Instant type) Folic Acid Impurity 6 Folic acid EP Impurity D Pteroic acid - min95% 4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoic acid Pyrofolic acid 4-(((2-AMino-4-oxo-3,4-dihydropteridin-6-yl)Methyl)aMino)benzoic acid Butterfly acid 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoicaci Pteroic acid (7CI, 8CI) Folic Acid Hydrate EP Impurity D 119-24-4 C14H12N6O3 Heterocyclic Building Blocks Quinazolines Building Blocks Heterocycles Building Blocks Chemical Synthesis Heterocyclic Building Blocks Building Blocks Heterocyclic Building Blocks Quinazolines