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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE structure

CAS No.: 28289-54-5

Chemical Name:: 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

Synonyms: MPTP;NSC 139654;Naphthoic Acid Impurity 111;1-METHYL-4-PHENYL-PIPERIDINE-3-EN;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin;1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine;1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE;N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE

CBNumber:: CB8254906

Molecular Formula:: C12H15N

Molecular Weight:: 173.25

MDL Number:: MFCD00006120

MOL File:: 28289-54-5.mol

MSDS File:: SDS

Last updated:2023-05-15 10:44:00

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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Properties

Melting point	aprox. 36°C
Boiling point	128-132 °C12 mm Hg(lit.)
Density	1.001±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	8.66±0.40(Predicted)
color	Pale Yellow to Light Yellow
Merck	13,6319
Stability	Stable. Incompatible with strong oxidizing agents.
FDA UNII	9P21XSP91P

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS06
Signal word	Danger
Hazard statements	H370-H301
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501
Hazard Codes	T
Risk Statements	25-39/23/24/25
Safety Statements	45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	UT8358900
HazardClass	6.1(b)
PackingGroup	III
Toxicity	Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	M3529-60	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	28289-54-5	25mg	$496	2021-12-16	Buy
SynQuest Laboratories	3H32-1-GU	1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine 95%	28289-54-5	250mg	$368	2021-12-16	Buy
Medical Isotopes, Inc.	12172	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	28289-54-5	25mg	$860	2021-12-16	Buy
SynQuest Laboratories	3H32-1-GU	1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine 95%	28289-54-5	1g	$912	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0018205	1-METHYL-4-PHENYL-PIPERIDINE-3-EN 95.00%	28289-54-5	25MG	$721.88	2021-12-16	Buy

Product number	Packaging	Price	Buy
M3529-60	25mg	$496	Buy
3H32-1-GU	250mg	$368	Buy
12172	25mg	$860	Buy
3H32-1-GU	1g	$912	Buy
CHM0018205	25MG	$721.88	Buy

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Definition

ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.

Metabolic pathway

N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a rat pheochromocytoma cell line is oxidized to give the N-methyl-4-phenylpyridinium ion.

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-31	1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE 28289-54-5	US $1.00 / g	1g	99%	200kg	Career Henan Chemical Co

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
28289-54-5
US $1.00 / g
99%
Career Henan Chemical Co

28289-54-5(1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE)Related Search:

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE phenindamine Setiptiline 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Xaliproden hydrochloride

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOLE-5-CARBOXYLIC ACID HYDROCHLORIDE 1-METHYL-4-(2-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Flupranone 2,3-dihydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine hydrobromide 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

phenindamine tartrate ROXINDOLE MESYLATE METHYL-4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINE, 1-, [METHYL-3H] 2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINENE TARTRATE METHYL-4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINE, 1-, [METHYL-14C]

1-phenyl-4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butan-1-one Fenpipalone

1of4

MPTP 1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride NSC 139654 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin 1-METHYL-4-PHENYL-PIPERIDINE-3-EN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) C12H15N 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 28289-54-5 Naphthoic Acid Impurity 111 28289-54-5 8289-54-5 Building Blocks C9 to C46 Heterocyclic Building Blocks Pyridines Neurochemicals Heterocyclic Compounds