Isonicotinamide
- CAS No.
- 1453-82-3
- Chemical Name:
- Isonicotinamide
- Synonyms
- PYRIDINE-4-CARBOXAMIDE;IsoniacinaMide;NSC 82353;Isonicotimide;AURORA KA-3066;Isonicotinamid;ISONICOTINAMIDE;4-AMidopyridine;Isonicoitnamide;Isonicotinamide99%
- CBNumber:
- CB8259608
- Molecular Formula:
- C6H6N2O
- Molecular Weight:
- 122.12
- MDL Number:
- MFCD00006432
- MOL File:
- 1453-82-3.mol
- MSDS File:
- SDS
| Melting point | 155-157 °C(lit.) |
|---|---|
| Boiling point | 227.52°C (rough estimate) |
| Density | 1.2236 (rough estimate) |
| refractive index | 1.5350 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pK1: 3.61(+1) (20°C) |
| color | White to Off-White |
| Water Solubility | 191.7 g/L (37 ºC) |
| BRN | 2173 |
| LogP | -0.28 |
| CAS DataBase Reference | 1453-82-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4H3BH6YX9Q |
| NIST Chemistry Reference | 4-Pyridinecarboxamide(1453-82-3) |
| EPA Substance Registry System | Isonicotinamide (1453-82-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NR9500000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
Isonicotinamide price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I17451 | Isonicotinamide ReagentPlus , 99% | 1453-82-3 | 25g | $45.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | I17451 | Isonicotinamide ReagentPlus , 99% | 1453-82-3 | 100g | $78.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14032 | 4-Pyridinecarboxylic acid amide for synthesis | 1453-82-3 | 50g | $71.3 | 2022-05-15 | Buy |
| TCI Chemical | I0135 | Isonicotinamide >99.0%(HPLC)(T) | 1453-82-3 | 25g | $29 | 2024-03-01 | Buy |
| TCI Chemical | I0135 | Isonicotinamide >99.0%(HPLC)(T) | 1453-82-3 | 500g | $178 | 2024-03-01 | Buy |
Isonicotinamide Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.
Application
Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.
Preparation
synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.
Definition
ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.
Purification Methods
Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]
Isonicotinamide Preparation Products And Raw materials
Raw materials
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Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 | admin@hbsaisier.cn | China | 747 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from Isonicotinamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Isonicotinamide
1453-82-3
|
US $115.00-100.00 / kilograms | 100kilograms | 99% | 100tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-04-18 | Isonicotinamide
1453-82-3
|
US $6.00 / KG | 1KG | More than 99% | 2000KG/MONTH | Hebei Saisier Technology Co., LTD | |
 |
2023-12-25 | Isonicotinamide
1453-82-3
|
US $0.00 / kg | 1kg | 99% | 1000000 | Hebei Jingbo New Material Technology Co., Ltd |
-
- Isonicotinamide
1453-82-3
- US $115.00-100.00 / kilograms
- 99%
- Hebei Dangtong Import and export Co LTD
-
- Isonicotinamide
1453-82-3
- US $6.00 / KG
- More than 99%
- Hebei Saisier Technology Co., LTD
-
- Isonicotinamide
1453-82-3
- US $0.00 / kg
- 99%
- Hebei Jingbo New Material Technology Co., Ltd