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WP1066

WP1066 Structure
WP1066 structure
CAS No.
857064-38-1
Chemical Name:
WP1066
Synonyms
WP1066;CS-604;WP1066, >=99%;WP1066/WP-1066;WP1066 USP/EP/BP;STAT Inhibitor III;WP1066 (DMSO solution);WP1066; WP 1066;WP-1066;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
CBNumber:
CB82616030
Molecular Formula:
C17H14BrN3O
Molecular Weight:
356.22
MDL Number:
MFCD12912450
MOL File:
857064-38-1.mol
MSDS File:
SDS
Last updated:2023-07-12 16:53:24
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WP1066 Properties

Melting point 90-93oC
Boiling point 569.9±50.0 °C(Predicted)
Density 1.425
storage temp. +2C to +8C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form Off-white solid
pka 11.00±0.46(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII 63V8AIE65T

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29333990
NFPA 704
0
2 0

WP1066 price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 573097 STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent. 857064-38-1 10mg $216 2024-03-01 Buy
Cayman Chemical 14736 WP1066 ≥95% 857064-38-1 1mg $32 2024-03-01 Buy
Cayman Chemical 14736 WP1066 ≥95% 857064-38-1 5mg $78 2024-03-01 Buy
Cayman Chemical 14736 WP1066 ≥95% 857064-38-1 10mg $109 2024-03-01 Buy
Cayman Chemical 14736 WP1066 ≥95% 857064-38-1 25mg $220 2024-03-01 Buy
Product number Packaging Price Buy
573097 10mg $216 Buy
14736 1mg $32 Buy
14736 5mg $78 Buy
14736 10mg $109 Buy
14736 25mg $220 Buy

WP1066 Chemical Properties,Uses,Production

Description

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-MG (IC50 = 5.6 μM) and U373-MG (IC50 = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.

Uses

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.

target

JAK2

References

1) Kong?et al.?(2005),?Discovery of WP1066, a novel Stat3/c-myc inhibitor with potent antitumor activity against human melanoma in vitro and in vivo;?Cancer Res.?65?1387 2) Iwamaru?et al.?(2007),?A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both invitro and in vivo;?Oncogene?26?2435 3) Ferraioli?et al.?(2007),?WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in acute Myelogenous Leukemia Cells;?Cancer Res.?67?11291 4) Kong,?et al.?(2008),?A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells;?Clin. Cancer Res.?14?5759 5) Kong,?et al.?(2009),?A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells;?Cancer Immunol. Immunother.?58?1023 6) Ma,?et al.?(2017),?Stat3 inhibitor abrogates the expression of PD-1 ligands on Lymphoma cell lines;?J. Clin. Exp. Hematop.?57?21

WP1066 synthesis

34160-40-2
1240041-69-3
857064-38-1
Synthesis of WP1066 from 6-Bromopyridine-2-carbaldehyde and 2-cyano-N-((S)-1-phenylethyl)acetamide

WP1066 Preparation Products And Raw materials

Raw materials

2-cyano-N-((S)-1-phenylethyl)acetamide 6-Bromopyridine-2-carbaldehyde

Preparation Products

WP1066 Suppliers

Global( 134)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29474 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
Chongqing Chemdad Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58

View Lastest Price from WP1066 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WP1066 pictures 2019-07-06 WP1066
857064-38-1
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • WP1066 pictures
  • WP1066
    857064-38-1
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

WP1066 Spectrum

WP1066(857064-38-1)1HNMR

857064-38-1(WP1066)Related Search:

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(2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid Pracinostat BAY 11-7085 ML264 Selumetinib
PD 0325901 Crizotinib Rapamycin Ruxolitinib Doxorubicin hydrochloride
LFM-A13 Brefeldin A 4-BROMOPYRIDINE

1of4

WP1066 (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP1066/WP-1066 (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066 WP1066, >=99% wp1066(STAT Inhibitor III) Stat3 Inhibitor III, WP1066 (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide WP1066 USP/EP/BP WP1066, 98%, a novel inhibitor of JAK2 and STAT3 CS-604 WP1066; WP 1066;WP-1066 STAT Inhibitor III 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-, (2E)- WP-1066 STAT3 Inhibitor III WP1066 WP1066 (DMSO solution) 857064-38-1 C17H14ON3Br Inhibitors JAK STAT Inhibitor API