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GAP 27

GAP 27 Structure
GAP 27 structure
CAS No.
198284-64-9
Chemical Name:
GAP 27
Synonyms
GAP 27;Gap 27（TFA);GAP 27, >98%;GAP-27; GAP27;SRPTEKTIFIIRPTEKTIFII;M.W. 1304.55 C60H101N15O17;Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27，Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%;Gap27,inhibit,Inhibitor,Gap-27,Gap 27,Gap Junction Protein
CBNumber:
CB8261625
Molecular Formula:
C60H101N15O17
Molecular Weight:
1304.53
MDL Number:
MFCD11045577
MOL File:
198284-64-9.mol
Last updated:2024-03-27 11:49:37
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GAP 27 Properties

Density 1.40±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble at 1mg/ml in 1% acetic acid
pka 3.41±0.10(Predicted)
form Solid
Water Solubility Soluble to 1 mg/ml in water
Sequence H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

GAP 27 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G1794 GAP 27 ≥97% (HPLC) 198284-64-9 2mg $179.6 2024-03-01 Buy
Alfa Aesar J64109 GAP 27 198284-64-9 0.5mg $70.9 2023-06-20 Buy
Alfa Aesar J64109 GAP 27 198284-64-9 1mg $110 2023-06-20 Buy
Tocris 1476 GAP 27 198284-64-9 1 $259 2021-12-16 Buy
TRC G245230 GAP 27 198284-64-9 2.5mg $385 2021-12-16 Buy
Product number Packaging Price Buy
G1794 2mg $179.6 Buy
J64109 0.5mg $70.9 Buy
J64109 1mg $110 Buy
1476 1 $259 Buy
G245230 2.5mg $385 Buy

GAP 27 Chemical Properties,Uses,Production

Uses

Gap27 is a connexin (Cx) mimetic peptide that inhibits connexin-mediated communication (CMC). In vitro, Gap27 has been shown to improve cell migration during scrape-wound repair in hyperglycemia/hyperinsulinemia conditions. It also reduces acetylcholine-induced hyperpolarization in smooth muscle cells.

Biological Activity

gap 27 is a peptide(ser-arg-pro-thr-glu-lys-thr-ile-phe-ile-ile) derived from connexin 43 that is a selective gap junction blocker.connexins, or gap junctions, are a family of structurally-related transmembrane proteins. gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. this intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. this synthetic connexin-mimetic peptide, gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. it was concluded that gap-junctional communication is necessary for proper bone remodeling.figure1 formula of gap 27

storage

Store at -20°C

References

1. Berthoud, V. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 279, 619 (2000)2. Ilvesaro, J. et al. BMC Musculoskel. Disord. 2, 10 (2001)3. Chaytor, A. et al. Brit. J. Pharmacol. 144, 108 (2005)4. Boitano, S. and H. Evans Am. J. Physio.l Lung Cell Mol. Physiol. 279, L623 ( 2000).

GAP 27 Preparation Products And Raw materials

Raw materials

Preparation Products

GAP 27 Suppliers

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3582 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd 		+8617531972939 anna@api-made.com China 2944 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
BOC Sciences 		58
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Hebei Miaoyin Technology Co.,Ltd 		58
Nanjing TGpeptide 		58
Zhejiang Hangyu API Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from GAP 27 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GAP 27 pictures 2020-02-14 GAP 27
198284-64-9
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
  • GAP 27 pictures
  • GAP 27
    198284-64-9
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

GAP 27 Spectrum

GAP 27(198284-64-9)MS

198284-64-9(GAP 27)Related Search:

H-ILE-ILE-OH GAP 27
H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE GAP 27 M.W. 1304.55 C60H101N15O17 Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile L-Isoleucine, L-seryl-L-arginyl-L-prolyl-L-threonyl-L-α-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl- Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98% GAP 27, >98% GAP-27; GAP27 Gap27,inhibit,Inhibitor,Gap-27,Gap 27,Gap Junction Protein Gap 27，Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile SRPTEKTIFIIRPTEKTIFII Gap 27（TFA) 198284-64-9 C60H102N15O17 C60H101N15O17 Cytoskeleton and Extracellular Matrix Cell Signaling and Neuroscience Cell Biology BioChemical Adhesion Molecules and Related Proteins Adhesion Molecules and Related Proteins Cell Signaling and Neuroscience Cytoskeleton and Extracellular Matrix Various Peptides Neuroscience