AST-1306
- CAS No.
- 897383-62-9
- Chemical Name:
- AST-1306
- Synonyms
- CS-590;ALS 1306;AST-1306;Allitinib;Allitinib (AST1306);N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide;N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide;N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-;anilino-quinazoline,Inhibitor,anti-cancer,Epidermal growth factor receptor,ALS1306,Allitinib,Irreversible,HER1,inhibit,AST1306,AST 1306,ALS-1306,ErbB-1,EGFR
- CBNumber:
- CB82620006
- Molecular Formula:
- C24H18ClFN4O2
- Molecular Weight:
- 448.88
- MDL Number:
- MFCD17169993
- MOL File:
- 897383-62-9.mol
| Boiling point | 655℃ |
|---|---|
| Density | 1.395 |
| Flash point | 350℃ |
| storage temp. | Store at -20°C |
| solubility | ≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 12.16±0.43(Predicted) |
| FDA UNII | CX0M5RO7CY |
| NCI Drug Dictionary | allitinib |
AST-1306 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A790045 | AST-1306 | 897383-62-9 | 200mg | $2470 | 2021-12-16 | Buy |
| Matrix Scientific | 143801 | N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 95% | 897383-62-9 | 100mg | $3108 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181197 | AST-1306 >98% | 897383-62-9 | 1000mg | $4469.3 | 2021-12-16 | Buy |
| Matrix Scientific | 143801 | N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide 95% | 897383-62-9 | 1g | $7178 | 2021-12-16 | Buy |
| AK Scientific | 2230AH | N-[4-[[3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl]-amino]-6-quinazolinyl]-2-propenamide | 897383-62-9 | 1g | $9740 | 2021-12-16 | Buy |
AST-1306 Chemical Properties,Uses,Production
Uses
AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor.
Uses
AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively.
Definition
ChEBI: N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-quinazolinyl]-2-propenamide is a member of quinazolines.
Biological Activity
ast1306 is a novel inhibitor of egfr and her2 (ic50 = 0.5 nm and 3 nm respectively)egfr (epidermal growth factor receptor) is a cell-surface receptor tyrosine kinase. the receptor activation leads to dimerization and tyrosine autophosphorylation. it induces a cascade of downstream cellular responses such as modification in gene expression, cell proliferation and cytoskeletal rearrangement etc. her2 is a member of the epidermal growth factor and is associated with breast and ovarian cancers.ast1306 selectively blocked egfr and her2 kinase activities in a cell-free assay. the tyrosine kinase activity of egfr mutant t790m/l858r was also inhibited by ast1306 in intact cell and cell-free assays. in addition, ast1306 attenuated the egfr and her2 phosphorylation and downstream substrates. [1]in erbb2-overexpressing xenograft and fvb-2/nneu transgenic mouse model, ast1306 potently inhibited tumor growth. in sk-ov-3 xenograft model, ast1306 caused a quick and long-lasting (≥24h) inhibition of egfr and her2. [1]
References
1. xie h, lin l, tong l et al. ast1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. plos one. 2011;6(7):e21487.
AST-1306 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15744 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
