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PSI 7851

PSI 7851 structure

CAS No.: 1064684-44-1

Chemical Name:: PSI 7851

Synonyms: GS9851;GS 9851;CS-1996;GS-9851;PSI 7851;PSI-7977, SOFOSBUVIR;5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine;N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;L-Alanine, N-[(2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (Sofosbuvir Impurity）

CBNumber:: CB82628299

Molecular Formula:: C22H29FN3O9P

Molecular Weight:: 529.45

MDL Number:

MOL File:: 1064684-44-1.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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PSI 7851 Properties

Density	1.41±0.1 g/cm3(Predicted)
pka	9.39±0.10(Predicted)
FDA UNII	3S5S1851OV

PSI 7851 Chemical Properties,Uses,Production

Uses

GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1].

References

[1] Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection
[2] Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus J. Med. Chem., Article ASAP DOI: 10.1021/jm100863x Publication Date (Web): September 16, 2010

PSI 7851 synthesis

Synthesis of PSI 7851 from 2'-deoxy-2'-fluoro-2'-C-methyluridine and L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester

PSI 7851 Preparation Products And Raw materials

Raw materials

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester 2'-deoxy-2'-fluoro-2'-C-methyluridine Phenyl dichlorophosphate

Preparation Products

PSI 7851 Suppliers

Global( 19)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29856	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32281	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9647	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49980	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Chengdu Feibo Pharm Technology Co., Ltd	+86 028-84641798 15982321820	abby@arkpharm.com	China	10922	58
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	6576	65

Supplier	Advantage
career henan chemical co	58
TargetMol Chemicals Inc.	58
changzhou huayang technology co., ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Chongqing Chemdad Co., Ltd	58
Amadis Chemical Company Limited	58
Chengdu Feibo Pharm Technology Co., Ltd	58
Daicel Chiral Technologies (China)CO.,LTD	65

View Lastest Price from PSI 7851 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-07	PSI 7851 1064684-44-1	US $3.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

PSI 7851
1064684-44-1
US $3.00 / KG
99%
Career Henan Chemical Co

1064684-44-1(PSI 7851)Related Search:

(S)-methyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester Sofosbuvir impurity M (R)-isopropyl 2-(((R)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate

PSI 7851 N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester PSI-7977, SOFOSBUVIR CS-1996 L-Alanine, N-[(2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester GS 9851 GS9851 GS-9851 5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (Sofosbuvir Impurity） 1064684-44-1