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XL-647

XL-647 structure

CAS No.: 781613-23-8

Chemical Name:: XL-647

Synonyms: KD-019;XL-647;Tesevatinib;XL647 /EXEL-7647;Tesevatinib(XL647);EXEL-7647;XL-647;XL 647;Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine;N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine;N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine;4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-

CBNumber:: CB82628532

Molecular Formula:: C24H25Cl2FN4O2

Molecular Weight:: 491.3853032

MDL Number:: MFCD23726660

MOL File:: 781613-23-8.mol

Last updated:2023-09-20 16:43:00

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XL-647 Properties

Boiling point	567.9±50.0 °C(Predicted)
Density	1.356
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form	A solid
pka	10.16±0.40(Predicted)
FDA UNII	F6XM2TN5A1
NCI Drug Dictionary	tesevatinib

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310

XL-647 price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27049	XL647	781613-23-8	1mg	$97	2024-03-01	Buy
Cayman Chemical	27049	XL647	781613-23-8	10mg	$672	2024-03-01	Buy
Cayman Chemical	27049	XL647	781613-23-8	5mg	$360	2024-03-01	Buy
ChemScene	CS-3666	Tesevatinib 99.21%	781613-23-8	5mg	$360	2021-12-16	Buy
ChemScene	CS-3666	Tesevatinib 99.21%	781613-23-8	10mg	$648	2021-12-16	Buy

Product number	Packaging	Price	Buy
27049	1mg	$97	Buy
27049	10mg	$672	Buy
27049	5mg	$360	Buy
CS-3666	5mg	$360	Buy
CS-3666	10mg	$648	Buy

XL-647 Chemical Properties,Uses,Production

Uses

XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.

Definition

ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.

XL-647 Preparation Products And Raw materials

Raw materials

Preparation Products

XL-647 Suppliers

Global( 63)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19639	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Jiangsu yize medical technology co. LTD	18550739526	3394205705@qq.com	China	2011	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61

Supplier	Advantage
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
changzhou huayang technology co., ltd	58
Aceschem Inc.	58
Amadis Chemical Company Limited	58
Jiangsu yize medical technology co. LTD	58
Shanghai Boyle Chemical Co., Ltd.	55
Chembest Research Laboratories Limited	61

View Lastest Price from XL-647 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-08	XL-647 781613-23-8	US $3.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

XL-647
781613-23-8
US $3.00 / KG
99%
Career Henan Chemical Co

XL-647 Spectrum

XL-647(781613-23-8)¹HNMR

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Tesevatinib Tesevatinib(XL647) XL-647 N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine EXEL-7647;XL-647;XL 647 KD-019 Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine XL647,Tesevatinib,EXEL 7647,KD019,HER1,Ephrin Receptor,Inhibitor,VEGFR,KD 019,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,EGFR,ErbB-1,XL 647,EXEL7647,inhibit XL647 /EXEL-7647 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]- N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine 781613-23-8 C24H25Cl2FN4O2