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Mito-TEMPO

CAS No.
1334850-99-5
Chemical Name:
Mito-TEMPO
Synonyms
MitoTEMP0;Mito-TEMPO;MitoTEMPO >=98% (HPLC);(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride;inhibit,Mito-TEMPO,Mitochondrial Metabolism,Reactive Oxygen Species,MitoTEMPO,Mito TEMPO,Inhibitor
CBNumber:
CB82645108
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD26406410
MOL File:
Mol file
MSDS File:
SDS
Last updated:2023-05-18 11:31:03

Mito-TEMPO Properties

storage temp. -20°C
solubility H2O: soluble10mg/mL, clear
form powder
color white to light brown
Stability Stable for 2 years from date of purchase as supplied

SAFETY

Risk and Safety Statements

WGK Germany  3

Mito-TEMPO price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0737 MitoTEMPO ≥98% (HPLC) 1334850-99-5 5mg $88.2 2024-03-01 Buy
Sigma-Aldrich SML0737 MitoTEMPO ≥98% (HPLC) 1334850-99-5 25mg $357 2024-03-01 Buy
ChemScene CS-0067207 Mito-TEMPO 98.05% 1334850-99-5 50mg $420 2021-12-16 Buy
ChemScene CS-0067207 Mito-TEMPO 98.05% 1334850-99-5 100mg $700 2021-12-16 Buy
ChemScene CS-0067207 Mito-TEMPO 98.05% 1334850-99-5 10mg $110 2021-12-16 Buy
Product number Packaging Price Buy
SML0737 5mg $88.2 Buy
SML0737 25mg $357 Buy
CS-0067207 50mg $420 Buy
CS-0067207 100mg $700 Buy
CS-0067207 10mg $110 Buy

Mito-TEMPO Chemical Properties,Uses,Production

Description

Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1?Resolves mitochondrial oxidative stress and rescues coronary collateral growth in Zucker obese fatty rats.2?Protects mitochondrial membrane potential and attenuates reperfusion-induced ROS production in a mouse ventricular myocyte model.3?Abrogates the induction of senescence in a human vascular smooth muscle cell model.4

Uses

MitoTEMPO has been used as a mitochondria-targeted antioxidant.

Biochem/physiol Actions

MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.

References

1) Liang?et al.?(2010)?SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery; Free Radic. Biol. Med.?49?1550 2) Pung?et al.?(2012)?Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats; Arterioscler. Thromb. Vasc. Biol.?32?325 3) DeSantiago?et al.?(2013)?Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity; Stem Cells Dev.?22?2497 4) Mistri?et al.?(2013)?A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells; Redox. Biol.?1?411

Mito-TEMPO Preparation Products And Raw materials

Raw materials

Preparation Products

Mito-TEMPO Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 meilunui@163.com China 4672 58
Shanghai Qianhao Biotechnology Co., LTD 13524877553 13524877553@163.com China 32 58
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4309 55
Mito-TEMPO (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride MitoTEMPO >=98% (HPLC) MitoTEMP0 inhibit,Mito-TEMPO,Mitochondrial Metabolism,Reactive Oxygen Species,MitoTEMPO,Mito TEMPO,Inhibitor 1334850-99-5