ChemicalBook >> CAS DataBase List >>UnifiraM

UnifiraM

CAS No.
272786-64-8
Chemical Name:
UnifiraM
Synonyms
UnifiraM;sunifiram DM-232;2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;Pyrrolo[1,2-a]pyrazin-6(2H)-one, 2-[(4-fluorophenyl)sulfonyl]hexahydro-;(8aR)-2-[(4-fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;2-[(4- fluorophenyl) sulfonyl] hexahydropyrrolo [1,2-A] pyrazine -6(2H)- one;2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
CBNumber:
CB82651143
Molecular Formula:
C13H15FN2O3S
Molecular Weight:
298.3332032
MDL Number:
MFCD20526948
MOL File:
272786-64-8.mol
Last updated:2024-08-21 22:41:43

UnifiraM Properties

Boiling point 479.5±55.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
form A solid
pka -0.82±0.20(Predicted)
color White to off-white
FDA UNII N4024LN29G

SAFETY

Risk and Safety Statements

UnifiraM price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0024519 UNIFIRAM 95.00% 272786-64-8 5MG $501.67 2021-12-16 Buy
Ambeed A751126 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 95+% 272786-64-8 250mg $50 2021-12-16 Buy
Ambeed A751126 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 95+% 272786-64-8 1g $118 2021-12-16 Buy
Ambeed A751126 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 95+% 272786-64-8 5g $415 2021-12-16 Buy
Product number Packaging Price Buy
API0024519 5MG $501.67 Buy
A751126 250mg $50 Buy
A751126 1g $118 Buy
A751126 5g $415 Buy

UnifiraM Chemical Properties,Uses,Production

Description

Unifiram (DM-232) is structurally similar to Sunifiram, and is a highly potent AMPAkine-line compound with effective cognition-enhancing and anti-amnesiac effects in animal models. Although sometimes grouped with racetam compounds, Unifiram is technically not a racetam due to the broken pyrrolidone backbone.
Animal research has shown that Unifiram has a significantly greater Nootropic potency than Piracetam or Phenylpiracetam. Unifiram is shares structural similarities to Sunifiram. Animal models show similar modes of action for both compounds – increased cognitive performance and anti-amnesiac effects through interactions with the glutamatergic system and particularly through AMPA-receptor activation.

Uses

Unifiram is a highly potent AMPAkine-like nootropic with antiamnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam.

benefits

Unifiram is believed to improve learning, memory, concentration, mental energy and basic cognition.

Mode of action

Although the Unifiram did not show any affinity for several important binding sites, it was found to prevent amnesia through modulation of various neurotransmitter systems and by increasing acetylcholine release in the cerebral cortex.
Unifiram's mechanism of action is known to be similar to that of Sunifiram. Sunifiram's mechanism of action is better defined than that of Unifiram, and we will briefly explain it here.
At a dosage range of 10-100nM, Sunifiram enhances NMDA-dependent signaling by increasing PKCα phosphorylation – dependent on glycine binding site availability and as an antagonist to glycine. The observable increase in AMPA receptor activation activity post-administration has been associated with increases in CAMKII and PKCα phosphorylation. Furthermore, the increased activity of AMPA receptor activation has been associated with increased CAMKII and PKCα phosphorylation.

UnifiraM Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12446 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325 sales1@chuanghaibio.com China 5866 58
Hubei Chuyan Biopharmaceutical Co., Ltd
+1-027-87896938 +15172028168 chuyan@chuyan.co China 24 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 973 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902 angelia@hbmojin.com China 1069 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21667 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9355 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29888 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58

View Lastest Price from UnifiraM manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
UnifiraM pictures 2024-09-18 UnifiraM
272786-64-8
US $20.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
Unifiram pictures 2024-09-18 Unifiram
272786-64-8
US $9.90-180.00 / g 10g 99% 1000kg Wuhan Cell Pharmaceutical Co., Ltd
 Nootropics pictures 2024-08-21 Nootropics
272786-64-8
US $11.00 / KG 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
  • UnifiraM pictures
  • UnifiraM
    272786-64-8
  • US $20.00 / kg
  • 99%
  • hebei hongtan Biotechnology Co., Ltd
  • Unifiram pictures
  • Unifiram
    272786-64-8
  • US $9.90-180.00 / g
  • 99%
  • Wuhan Cell Pharmaceutical Co., Ltd
  •  Nootropics pictures
  • Nootropics
    272786-64-8
  • US $11.00 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD
2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one (8aR)-2-[(4-fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one Pyrrolo[1,2-a]pyrazin-6(2H)-one, 2-[(4-fluorophenyl)sulfonyl]hexahydro- UnifiraM 2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one sunifiram DM-232 2-[(4- fluorophenyl) sulfonyl] hexahydropyrrolo [1,2-A] pyrazine -6(2H)- one 272786-64-8