UnifiraM
- CAS No.
- 272786-64-8
- Chemical Name:
- UnifiraM
- Synonyms
- UnifiraM;sunifiram DM-232;2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;Pyrrolo[1,2-a]pyrazin-6(2H)-one, 2-[(4-fluorophenyl)sulfonyl]hexahydro-;(8aR)-2-[(4-fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;2-[(4- fluorophenyl) sulfonyl] hexahydropyrrolo [1,2-A] pyrazine -6(2H)- one;2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
- CBNumber:
- CB82651143
- Molecular Formula:
- C13H15FN2O3S
- Molecular Weight:
- 298.3332032
- MDL Number:
- MFCD20526948
- MOL File:
- 272786-64-8.mol
| Boiling point | 479.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml |
| form | A solid |
| pka | -0.82±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | N4024LN29G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
UnifiraM price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0024519 | UNIFIRAM 95.00% | 272786-64-8 | 5MG | $501.67 | 2021-12-16 | Buy |
| Ambeed | A751126 | 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 95+% | 272786-64-8 | 250mg | $50 | 2021-12-16 | Buy |
| Ambeed | A751126 | 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 95+% | 272786-64-8 | 1g | $118 | 2021-12-16 | Buy |
| Ambeed | A751126 | 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 95+% | 272786-64-8 | 5g | $415 | 2021-12-16 | Buy |
UnifiraM Chemical Properties,Uses,Production
Description
Unifiram (DM-232) is structurally similar to Sunifiram, and is a highly potent AMPAkine-line compound with effective cognition-enhancing and anti-amnesiac effects in animal models. Although sometimes grouped with racetam compounds, Unifiram is technically not a racetam due to the broken pyrrolidone backbone.
Animal research has shown that Unifiram has a significantly greater Nootropic potency than Piracetam or Phenylpiracetam. Unifiram is shares structural similarities to Sunifiram. Animal models show similar modes of action for both compounds – increased cognitive performance and anti-amnesiac effects through interactions with the glutamatergic system and particularly through AMPA-receptor activation.
Uses
Unifiram is a highly potent AMPAkine-like nootropic with antiamnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam.
benefits
Unifiram is believed to improve learning, memory, concentration, mental energy and basic cognition.
Mode of action
Although the Unifiram did not show any affinity for several important binding sites, it was found to prevent amnesia through modulation of various neurotransmitter systems and by increasing acetylcholine release in the cerebral cortex.
Unifiram's mechanism of action is known to be similar to that of Sunifiram. Sunifiram's mechanism of action is better defined than that of Unifiram, and we will briefly explain it here.
At a dosage range of 10-100nM, Sunifiram enhances NMDA-dependent signaling by increasing PKCα phosphorylation – dependent on glycine binding site availability and as an antagonist to glycine. The observable increase in AMPA receptor activation activity post-administration has been associated with increases in CAMKII and PKCα phosphorylation. Furthermore, the increased activity of AMPA receptor activation has been associated with increased CAMKII and PKCα phosphorylation.
UnifiraM Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5872 | 58 |
| Hubei Chuyan Biopharmaceutical Co., Ltd | +1-027-87896938 +15172028168 | chuyan@chuyan.co | China | 24 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
| Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1069 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9355 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
View Lastest Price from UnifiraM manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-19 | Nootropics
272786-64-8
|
US $11.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-09-19 | UnifiraM
272786-64-8
|
US $20.00 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-09-18 | Unifiram
272786-64-8
|
US $9.90-180.00 / g | 10g | 99% | 1000kg | Wuhan Cell Pharmaceutical Co., Ltd |
-
- Nootropics
272786-64-8
- US $11.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- UnifiraM
272786-64-8
- US $20.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- Unifiram
272786-64-8
- US $9.90-180.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd