ChemicalBook >> CAS DataBase List >>5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride structure

CAS No.: 720720-96-7

Chemical Name:: 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

Synonyms: 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;SWF-2;5-Methyl-4;Edoxaban-2;Edoxaban iMpurities 2;Yidu Saban Impurity B;Edoxaban Impurity 4 HCl;Edoxaban Impurity 32 HCl;Edoxaban Impurity B（HCl）;Edoxaban Impurity 21 HCl

CBNumber:: CB82655282

Molecular Formula:: C8H11ClN2O2S

Molecular Weight:: 234.7

MDL Number:: MFCD25542379

MOL File:: 720720-96-7.mol

MSDS File:: SDS

Last updated:2023-09-08 21:17:32

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5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Properties

Melting point	199.0 to 203.0 °C
Boiling point	175℃[at 101 325 Pa]
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly)
form	Solid
color	Pale Beige to Light Brown
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H335-H315-H319
Precautionary statements	P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code	2934.10.2000

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2819	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride >97.0%(HPLC)	720720-96-7	200mg	$25	2024-03-01	Buy
TCI Chemical	M2819	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride >97.0%(HPLC)	720720-96-7	1g	$74	2024-03-01	Buy
TRC	M330085	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride	720720-96-7	25g	$820	2021-12-16	Buy
Medical Isotopes, Inc.	66235	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylicAcidHCl	720720-96-7	5G	$675	2021-12-16	Buy
ChemScene	CS-M3401	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride	720720-96-7	5g	$58	2021-12-16	Buy

Product number	Packaging	Price	Buy
M2819	200mg	$25	Buy
M2819	1g	$74	Buy
M330085	25g	$820	Buy
66235	5G	$675	Buy
CS-M3401	5g	$58	Buy

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Chemical Properties,Uses,Production

Uses

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).

Preparation

2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.61 mg), ethanol (5 mL), and 4N aqueous lithium hydroxide (1.34 mL) were mixed at room temperature, and the resultant mixture was stirred at 50 °C for 7 hours. Until the reaction mixture was cooled with ice-water, 1N HCl in ethanol (7.5 mL) was added to the mixture. It was stirred for 1.5 hours. The precipitated crystals were collected by filtration, and were washed with ethanol (2 mL). The wet crystal was dried at room temperature under reduced pressure to obtain 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride.

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride synthesis

Synthesis of 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride from Edoxaban Impurity 29 and PHENYL FORMATE

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Preparation Products And Raw materials

Raw materials

4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl- 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Edoxaban Impurity 29 1-Methyl-4-piperidone

Preparation Products

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Suppliers

Global( 331)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd	+8618928027945	sales3@zhhairuide.com	China	97	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	723	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7838	58

Supplier	Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58

View Lastest Price from 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-19	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7	US $5.00 / kg	1kg	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2023-09-08	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7	US $30.00 / kg	1kg	99%	20 tons	Anhui Ruihan Technology Co., Ltd
2023-09-08	5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7	US $30.00 / kg	1kg	99%	20 tons	Anhui Ruihan Technology Co., Ltd

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
720720-96-7
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
720720-96-7
US $30.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
720720-96-7
US $30.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Spectrum

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(720720-96-7)¹HNMR

720720-96-7(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride)Related Search:

EthanediaMide, N1-(5-chlo... Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl- 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester

edoxaban Edoxaban Edoxaban Impurity 8 Oxalic acid 1-ethyl ester Edoxaban Impurity 29

INDEX NAME NOT YET ASSIGNED Edoxaban-d6 Edoxaban Impurity 16 (1S,3S,4S)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester EthanediaMide iMpurity D

EthanediaMide, N1-(5-chlo... EthanediaMide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2S,4R)-4-[(diMethylaMino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-Methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]aMino]cyclohexyl]- (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid

1of4

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride EthanediaMide iMpurity B HCL 5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Thiazolo[5,4-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-5-Methyl-, hydrochloride (1:1) 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(for Edoxaban) 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridin 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid HCl Edoxaban Impurity 18 Hydrochloride 5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid,hydrochloride 5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid 4-c]pyridine-2-carboxylic acid hydrochloride 5-Methyl-4 Edoxaban iMpurities 2 Edoxaban-2 4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid, hydrochloride (1:1) Edoxaban Impurity 32 HCl 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(For export only) 4,5,6,7-tetrahydro-5-methyl-thiazolo[5,4-c]pyridin-2-carboxylic acid hydrochloride SWF-2 Edoxaban side chain 2 hydrochloride 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydroch 4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine-2-carbox... 4,5,6,7-tetrahydro-5-Methy-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5- methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide / Edoxaban free base Yidu Saban Impurity B Edoxaban Impurity B（HCl） Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Edoxaban Impurity 21 HCl Edoxaban Impurity 12 HCl Edoxaban Impurity 4 HCl 720720-96-7 125529-26-0