3-Chloro-6-Methoxypyrazin-2-aMine
- CAS No.
- 13484-56-5
- Chemical Name:
- 3-Chloro-6-Methoxypyrazin-2-aMine
- Synonyms
- 3-Chloro-6-Methoxypyrazin-2-aMine;3-chloro-6-methoxy-2-Pyrazinamine;3-Amino-2-chloro-5-methoxypyrazine;2-Amino-3-chloro-6-methoxypyrazine;2-Pyrazinamine, 3-chloro-6-methoxy-;3-Chloro-6-methoxy-pyrazin-2-ylamine
- CBNumber:
- CB82661232
- Molecular Formula:
- C5H6ClN3O
- Molecular Weight:
- 159.57
- MDL Number:
- MFCD20691296
- MOL File:
- 13484-56-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P280 |
3-Chloro-6-Methoxypyrazin-2-aMine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 9965CS | 3-Chloro-6-methoxypyrazin-2-amine | 13484-56-5 | 100mg | $223 | 2021-12-16 | Buy |
| AK Scientific | 9965CS | 3-Chloro-6-methoxypyrazin-2-amine | 13484-56-5 | 1g | $527 | 2021-12-16 | Buy |
| Chemenu | CM168802 | 3-chloro-6-methoxypyrazin-2-amine 95% | 13484-56-5 | 1g | $631 | 2021-12-16 | Buy |
| Crysdot | CD11289818 | 3-Chloro-6-methoxypyrazin-2-amine 95+% | 13484-56-5 | 1g | $668 | 2021-12-16 | Buy |
| Alichem | 13484565 | 3-Chloro-6-methoxypyrazin-2-amine | 13484-56-5 | 1g | $708.75 | 2021-12-16 | Buy |
3-Chloro-6-Methoxypyrazin-2-aMine Chemical Properties,Uses,Production
Synthesis
6905-47-1
13484-56-5
General procedure for the synthesis of 2-amino-3-chloro-6-methoxypyrazine from 2-amino-6-methoxypyrazine: to a solution of 2-amino-6-methoxypyrazine (3 g, 24 mmol) in anhydrous N,N-dimethylformamide (DMF, 35 mL) was added N-chlorosuccinimide (NCS, 3.2 g, 24 mmol). The reaction mixture was stirred at room temperature for 16 h. After the reaction was completed, the mixture was poured into a mixture of ice and brine (130 mL). The aqueous phase was extracted with ethyl acetate (3 x 120 mL), the organic phases were combined, washed with 5% lithium chloride (LiCl) solution, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by SNAP-340-NH column chromatography (eluent: cyclohexane/ethyl acetate, gradient from 95:5 to 8:2) and SNAP1 00-Si-OH column chromatography (eluent: dichloromethane) to afford the target product, 2-amino-3-chloro-6-methoxypyrazine (1.98 g, 12.5 mmol, 52% yield). lc-MS (M-H) = 160.1.
References
[1] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 84; 85
3-Chloro-6-Methoxypyrazin-2-aMine Preparation Products And Raw materials
3-Chloro-6-Methoxypyrazin-2-aMine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 11000 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42953 | 64 |
| Shanghai TuZhi Chemical Co., Ltd. | 19542790274 | 2119559397@qq.com | China | 1000 | 50 |
| TaiChem Taizhou Limited | 052386810091 | zcwy9518@yeah.net | China | 3912 | 58 |
| Shijiazhuang Jing Kang Technology Co.Ltd. | 13933818572 | 1519554262@qq.com | China | 1785 | 58 |
| Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 16027 | 58 |
| Lanzhou Kangyuxin Biotechnology Co., Ltd. | 0931-4190454 13893344397 | sales@kyxpharma.com | China | 2979 | 58 |
| Huansheng Meisen Pharmaceutical Technology (Shandong) Co., Ltd | 0531-88762217 18301471076 | sales@acespharma.com | China | 3863 | 58 |
