ChemicalBook >> CAS DataBase List >>GZD 824
GZD 824
- CAS No.
- 1257628-77-5
- Chemical Name:
- GZD 824
- Synonyms
- GZD824;GZD8824;GZD-824;GZD 824;GZD-824 Free;Olverembatinib;GZD 824 USP/EP/BP;GZD824;GZD-824;GZD 824;Olverembatinib (GZD824);GZD-824; GZD 824;BENZAMIDE
- CBNumber:
- CB82666626
- Molecular Formula:
- C29H27F3N6O
- Molecular Weight:
- 532.56
- MDL Number:
- MFCD26142930
- MOL File:
- 1257628-77-5.mol
- MSDS File:
- SDS
Last updated:2023-09-20 16:43:00
| Boiling point | 630.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 100 mg/mL (187.77 mM) |
| form | A crystalline solid |
| pka | 9.04±0.40(Predicted) |
| FDA UNII | KV1M7Q3CBP |
GZD 824 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21508 | GZD-824 ≥98% | 1257628-77-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21508 | GZD-824 ≥98% | 1257628-77-5 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 21508 | GZD-824 ≥98% | 1257628-77-5 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 21508 | GZD-824 ≥98% | 1257628-77-5 | 25mg | $456 | 2024-03-01 | Buy |
| TRC | G932028 | GZD824 | 1257628-77-5 | 10mg | $195 | 2021-12-16 | Buy |
GZD 824 Chemical Properties,Uses,Production
Description
GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.
Uses
GZD824 is a orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) kinases. It is a COVID19-related research product.
GZD 824 Preparation Products And Raw materials
Global( 92)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
1257628-77-5(GZD 824)Related Search:
4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
3-(2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
GZD8824
GZD824;GZD-824;GZD 824
GZD-824 Free
GZD 824
GZD824
GZD-824
GZD-824; GZD 824;BENZAMIDE
Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-
GZD 824 USP/EP/BP
3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Olverembatinib
Olverembatinib (GZD824)
1257628-77-5
257628-77-5
Inhibitors