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1-BOC-Piperazine

1-BOC-Piperazine Structure
1-BOC-Piperazine structure
CAS No.
57260-71-6
Chemical Name:
1-BOC-Piperazine
Synonyms
1-BOC-PIPERAZINE;BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene
CBNumber:
CB8268275
Molecular Formula:
C9H18N2O2
Molecular Weight:
186.25
MDL Number:
MFCD00075265
MOL File:
57260-71-6.mol
MSDS File:
SDS
Last updated:2025-07-07 08:31:03
Product description Number Pack Size Price
1-Boc-piperazine ≥98.0% (GC) 15502 5g $114
1-Boc-piperazine ≥98.0% (GC) 15502 25g $273
1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) B2415 5g $71
1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) B2415 25g $228
1-Boc-piperazine 97% 343536 1g $35.4
More product size
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1-BOC-Piperazine Properties

Melting point 43-47 °C(lit.)
Boiling point 98-100
Density 1.030±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in DMSO
pka 8.45±0.10(Predicted)
form Low Melting Crystalline Mass
color White to light yellow
Water Solubility Soluble in ethyl acetate, methanol and water.
Sensitive Air Sensitive
BRN 879985
InChIKey CWXPZXBSDSIRCS-UHFFFAOYSA-N
CAS DataBase Reference 57260-71-6(CAS DataBase Reference)
FDA UNII LBC2X3S28C
NIST Chemistry Reference T-butyl 1-piperaziencarboxylate(57260-71-6)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3263
WGK Germany  3
F  3-10-34
HazardClass  IRRITANT
HS Code  29335995
NFPA 704
1
2 0

1-BOC-Piperazine price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 15502 1-Boc-piperazine ≥98.0% (GC) 57260-71-6 5g $114 2025-07-31 Buy
Sigma-Aldrich 15502 1-Boc-piperazine ≥98.0% (GC) 57260-71-6 25g $273 2025-07-31 Buy
TCI Chemical B2415 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) 57260-71-6 5g $71 2025-07-31 Buy
TCI Chemical B2415 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) 57260-71-6 25g $228 2025-07-31 Buy
Sigma-Aldrich 343536 1-Boc-piperazine 97% 57260-71-6 1g $35.4 2025-07-31 Buy
Product number Packaging Price Buy
15502 5g $114 Buy
15502 25g $273 Buy
B2415 5g $71 Buy
B2415 25g $228 Buy
343536 1g $35.4 Buy

1-BOC-Piperazine Chemical Properties,Uses,Production

Uses

N-Boc-piperazine is a compound useful in organic synthesis.

Chemical Properties

Waxy Solid

Uses

1-Boc-piperazine may be used in:

  • preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
  • termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
  • preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors

Uses

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

Application

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.

General Description

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

1-BOC-Piperazine synthesis

110-85-0
24424-99-5
57260-71-6
Synthesis of 1-BOC-Piperazine from Piperazine and Di-tert-butyl dicarbonate

1-BOC-Piperazine Preparation Products And Raw materials

Raw materials

Ethanol Di-tert-butyl dicarbonate Piperazine Dichloromethane Methanol
Sodium hydroxide PETROLEUM ETHER

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Preparation Products

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 1-(2-Methoxyethyl)piperazine 1-(CYCLOPROPYLMETHYL)PIPERAZINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%
1-Boc-4-(2-formylphenyl)piperazine 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 1-(2-PYRAZINYL)-PIPERAZINE 1-(3-Chlorphenyl)piperazine N-Boc-4-(Cyclopropylmethyl)piperazine
1303512-02-8 4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Trimetazidine

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1-BOC-Piperazine Suppliers

Global( 854)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd
+86-531-82375818 +86-15064153060 sales01@jndxj.com China 301 58
Nanjing Sinoda Biological Technology Co., Ltd
+8613401983379 sales@njmcn.cn CHINA 74 58
BTC pharm India
+918790379245 banny.janga@btcpharm.com India 1262 58
Guangzhou Tosun Pharmaceutical Limited
+86-18124244216 +86-18124244216 info@upharm.cn China 998 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8770 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12217 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 286 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Supplier Advantage
Anhui Dexinjia Biopharm Co., Ltd
58
Nanjing Sinoda Biological Technology Co., Ltd
58
BTC pharm India
58
Guangzhou Tosun Pharmaceutical Limited
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58

Related articles

View Lastest Price from 1-BOC-Piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl 1-piperazinecarboxylate pictures 2025-11-14 tert-Butyl 1-piperazinecarboxylate
57260-71-6
 US $19.90 / kg 1kg 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
N-Boc-piperazine pictures 2025-09-25 N-Boc-piperazine
57260-71-6
 US $5.00-0.50 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
tert-Butyl 1-piperazinecarboxylate pictures 2025-08-08 tert-Butyl 1-piperazinecarboxylate
57260-71-6
 US $0.00 / KG 1KG 99% 50000KG/month Sichuan Zhuoyu Yantang Technology Co., Ltd.

1-BOC-Piperazine Spectrum

tert-Butyl 1-piperazinecarboxylate(57260-71-6)1HNMRtert-Butyl 1-piperazinecarboxylate(57260-71-6)FT-IRtert-Butyl 1-piperazinecarboxylate(57260-71-6)IRtert-Butyl 1-piperazinecarboxylate(57260-71-6)Raman

57260-71-6(1-BOC-Piperazine )Related Search:

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1-Boc-piperazine,99% 1-(tert-Butyloxycarbonyl)piperazine 1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester 1-Piperazinecarboxylic Acid tert-Butyl Este N-(tert-Butoxycarbonyl)piperazine 98% Piperazine, N1-BOC protected tert-Butyl 2-piperazinecarboxylate N-(T-BUTYLOXYCARBONYL)-PIPERAZINE BUTTPARK 52\11-35 BOC-PAZ 1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate 1-BOC-PIPERAZINE, PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-BOC-PIPERAZINE 99+% Piperazine, N1-BOC protected 98% 1-BOC-PIPERAZINE hydrochloride N-Boc-piperazine [N-(tert-Butoxycarbonyl)-piperazine] 1-Boc-piperazine >=98.0% (GC) 1-Boc-piperazine 97% N - bok - piperazine 1-Boc-piperazine≥ 99%(GC) tert-Butyl 1-piperazinecarboxyl N-Boc-piperazine hydrochloride 1-Boc-piperazine ,98% tert-Butyl 1-piperazinecarboxylate,97% tert-Butyl 1-piperazinecarboxylate，1-N-Boc-Piperazine 1-Boc-piperazine,tert-Butyl piperazine-1-carboxylate tert-butyl piperazine-1-carboxylate(SALTDATA: FREE) t-Butyl 1-piperazincarboxylate TERT-BUTYL N-PIPERAZINE TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE TERT-BUTYL 1-PIPERAZINECARBOXYLATE RARECHEM AR PA 0026 PIBOC N-(T-BOC)PIPERAZINE N-T-BUTOXYCARBONYLPIPERAZINE N-(TERT-BUTOXYCARBONYL)PIPERAZINE 1-[(1,1-DiMethylethoxy)carbonyl]piperazine 1-Piperazinecarboxylic Acid tert-Butyl Ester N-(tert-Butoxycarbonyl)piperazine, tert-Butyl piperazine-1-carboxylate tert-Butyl 1-piperazinecarboxylate, 97% 5GR tert-butyl piperazine-1-carbox 1,1-Dimethylethyl 1-piperazinecarboxylate Tert-Butyl 1-Piperazinecarboxylate1 tert-Butyl 1-piperazincarboxylate 1-Boc-piperazine, 98%, for synthesis 1-(tert-Butoxycarbonyl)piperazine > Avatrombopag Impurity 28 BOC-PAZ/1-Boc-piperazine tert-Butyl 1-piperazinecarboxylate ISO 9001：2015 REACH tert-butyl piperazine-1-carboylate Tertbutylpiperzine-1-carboxylate (N-Boc-piperazine) t-BUTYL PIPERZINE-1-CARBOXYLATE CAS:57260-71-6 tert-Butyl 1-piperazinecarboxylate 1-BOC-Piperazine extrapure, 99% BOC-PIPERAZINE PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-BOC-PIPERAZINE N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE