Atglistatin
- CAS No.
- 1469924-27-3
- Chemical Name:
- Atglistatin
- Synonyms
- istatin;CS-1024;Atglistatin;Atglistatin, >=98%;3-(4'-(DIMETHYLAMINO)BIPHENYL-3-YL)-1,1-DIMETHYLUREA;3-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea;N'-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylurea;3-(4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)-1,1-dimethylurea;3-(4'-(Dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea;Urea, N'-[4'-(dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethyl-
- CBNumber:
- CB82685322
- Molecular Formula:
- C17H21N3O
- Molecular Weight:
- 283.37
- MDL Number:
- MFCD28009494
- MOL File:
- 1469924-27-3.mol
- MSDS File:
- SDS
| Boiling point | 498.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.135±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming) |
| form | powder |
| pka | 15.01±0.70(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H315-H335 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36/37/39 | |||||||||
| NFPA 704 |
|
Atglistatin price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1075 | Atglistatin ≥98% (HPLC) | 1469924-27-3 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1075 | Atglistatin ≥98% (HPLC) | 1469924-27-3 | 25MG | $486 | 2023-06-20 | Buy |
| Cayman Chemical | 15284 | Atglistatin ≥95% | 1469924-27-3 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 15284 | Atglistatin ≥95% | 1469924-27-3 | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 15284 | Atglistatin ≥95% | 1469924-27-3 | 10mg | $161 | 2024-03-01 | Buy |
Atglistatin Chemical Properties,Uses,Production
Description
Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-
Uses
Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).
Biochem/physiol Actions
Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.
References
1) Mayer et al. (2013), Development of small-molecule inhibitors targeting adipose triglyceride lipase; Nat. Chem. Biol. 9 785 2) Zagani et al. (2015) Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells; Oncotarget 6 28282
Atglistatin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
View Lastest Price from Atglistatin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-04 | Atglistatin
1469924-27-3
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
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- Atglistatin
1469924-27-3
- US $5.00 / KG
- 99%
- Career Henan Chemical Co