4EGI-1
- CAS No.
- 315706-13-9
- Chemical Name:
- 4EGI-1
- Synonyms
- 4EGI-1;CS-1896;CS-1408;4EGI-1/4EGI1;4EGI-1, >=98%;eIF4E/eIF4G Interaction Inhibitor, 4EGI-1;2-(2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid;4EGI1,Autophagy,inhibit,Eukaryotic Initiation Factor (eIF),Inhibitor,4EGI-1,Apoptosis;α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid;Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-
- CBNumber:
- CB82708126
- Molecular Formula:
- C18H12Cl2N4O4S
- Molecular Weight:
- 451.28
- MDL Number:
- MFCD28142689
- MOL File:
- 315706-13-9.mol
- MSDS File:
- SDS
| Boiling point | 668.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥22.56 mg/mL in DMSO |
| form | Brown solid. |
| pka | 0.89±0.41(Predicted) |
| FDA UNII | H57REU3DHP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 |
4EGI-1 price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 324519 | InSolution eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem | 315706-13-9 | 5MG | $172 | 2024-03-01 | Buy |
| Sigma-Aldrich | 324517 | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem | 315706-13-9 | 10MG | $272 | 2024-03-01 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 315706-13-9 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 315706-13-9 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 315706-13-9 | 10mg | $214 | 2024-03-01 | Buy |
4EGI-1 Chemical Properties,Uses,Production
Description
In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G. 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM). It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation. 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis. Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders. 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.
Uses
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 is amplifies TRAIL-induced apoptosis via down-regulation of FLIPS/L?and induction of DR5.
Definition
ChEBI: 4EGI-1 is a dichlorobenzene, a member of 1,3-thiazoles, a C-nitro compound, a monocarboxylic acid and a hydrazone.
storage
Store at -20°C
References
[1] moerke n j, aktas h, chen h, et al. small-molecule inhibition of the interaction between the translation initiation factors eif4e and eif4g. cell, 2007, 128(2): 257-267.
4EGI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |