1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
- CAS No.
- 1220696-38-7
- Chemical Name:
- 1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
- Synonyms
- 1-Methyl-2-oxoindoline-5-boronic Acid Pinacol Ester;1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one;1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB82709961
- Molecular Formula:
- C15H20BNO3
- Molecular Weight:
- 273.14
- MDL Number:
- MFCD18383773
- MOL File:
- 1220696-38-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one | M340055 | 10mg | $45 |
| 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 97% | M17659 | 250mg | $250 |
| 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)indolin-2-one | 1107DP | 250mg | $316 |
| 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 97% | M17659 | 100mg | $170 |
| 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-2-ONE 95.00% | BOR0007491 | 5MG | $501.63 |
| Boiling point | 468.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -0.19±0.20(Predicted) |
| Appearance | Light brown to brown Solid |
| InChI | InChI=1S/C15H20BNO3/c1-14(2)15(3,4)20-16(19-14)11-6-7-12-10(8-11)9-13(18)17(12)5/h6-8H,9H2,1-5H3 |
| InChIKey | IGFPFGIDECTAJQ-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(C=C(B3OC(C)(C)C(C)(C)O3)C=C2)CC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M340055 | 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one | 1220696-38-7 | 10mg | $45 | 2021-12-16 | Buy |
| Synthonix | M17659 | 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 97% | 1220696-38-7 | 250mg | $250 | 2021-12-16 | Buy |
| AK Scientific | 1107DP | 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)indolin-2-one | 1220696-38-7 | 250mg | $316 | 2021-12-16 | Buy |
| Synthonix | M17659 | 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 97% | 1220696-38-7 | 100mg | $170 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BOR0007491 | 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-2-ONE 95.00% | 1220696-38-7 | 5MG | $501.63 | 2021-12-16 | Buy |
1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Chemical Properties,Uses,Production
Synthesis
20870-90-0
73183-34-3
1220696-38-7
1. 5-Bromo-1-methyl-2-oxodihydroindole (537 mg, 2.375 mmol), pinacol bis(boronic acid) (987 mg, 3.89 mmol), potassium acetate (636 mg, 6.48 mmol), Pd(dppf)Cl2-CH2Cl2 (88 mg, 0.108 mmol) and 1,2-di-methoxyethane (15.6 mL) were sequentially added to the microwave reaction vial. -dimethoxyethane (15.6 mL). 2. The reaction mixture was stirred at 80 °C overnight. 3. Upon completion of the reaction, the reaction solution was concentrated and the solvent was removed. 4. The crude product was purified by silica gel column chromatography (Biotage system, cyclohexane/ethyl acetate gradient elution) to afford the target compound 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dihydroindol-2-one (500 mg, 85% yield). 5. The structure of the product was confirmed by 1H-1H-1 , 1H-1 ,2,3,2-dihydroxyethylene dimethoxyethane (15.6 mL). 5. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3): δ 7.78 (d, J = 7.7 Hz, 1H), 7.69 (s, 1H), 6.84 (d, J = 7.7 Hz, 1H), 3.52 (s, 2H), 3.24 (s, 3H), 1.36 (s, 12H). 6. LC-MS (ESI, m/z) analysis showed Rt = 2.90 min, [M-H]- m/z = 274 (HPLC method E).
References
[1] Patent: WO2015/144290, 2015, A1. Location in patent: Page/Page column 94
[2] Patent: WO2010/130794, 2010, A1. Location in patent: Page/Page column 54; 55
[3] Patent: US2016/9720, 2016, A1. Location in patent: Paragraph 0589
[4] Patent: US2016/9712, 2016, A1. Location in patent: Paragraph 0365
[5] Patent: US2016/289238, 2016, A1. Location in patent: Paragraph 0318; 0319
1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| Young Lively PharminBlock Co.,Ltd | +undefined18600731423 | jason_gao@yl-pharminblock.com | China | 1944 | 58 |
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| Nanjing SynTitan Pharmaceutical Co., Ltd. | 025-57027686 17372956142 | li_lan@syntitan.com | China | 9998 | 58 |
