Cerdulatinib
- CAS No.
- 1198300-79-6
- Chemical Name:
- Cerdulatinib
- Synonyms
- PRT-062070;CS-1823;PRT2070);Cerdulatinib;Cerdulatinib D5;Cerdulatinib (PRT2070);PRT062070(Cerdulatnib);Cerdulatinib(PRT-062070;PRT 062070 (Cerdulatinib);Cerdulatinib trifluoroacetate salt
- CBNumber:
- CB82715618
- Molecular Formula:
- C20H27N7O3S
- Molecular Weight:
- 445.54
- MDL Number:
- MFCD28167811
- MOL File:
- 1198300-79-6.mol
- MSDS File:
- SDS
| Melting point | >211°C (dec.) |
|---|---|
| Boiling point | 741.9±70.0 °C(Predicted) |
| Density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 14.17±0.50(Predicted) |
| color | Light Yellow Brown |
| FDA UNII | D1LXQ45S1O |
| NCI Drug Dictionary | cerdulatinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Cerdulatinib price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20076 | Cerdulatinib ≥98% | 1198300-79-6 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 20076 | Cerdulatinib ≥98% | 1198300-79-6 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 20076 | Cerdulatinib ≥98% | 1198300-79-6 | 25mg | $225 | 2024-03-01 | Buy |
| Cayman Chemical | 20076 | Cerdulatinib ≥98% | 1198300-79-6 | 50mg | $419 | 2024-03-01 | Buy |
| TRC | C273000 | Cerdulatinib(PRT2070) | 1198300-79-6 | 100mg | $590 | 2021-12-16 | Buy |
Cerdulatinib Chemical Properties,Uses,Production
Uses
Cerdulatinib (PRT2070), acts as a novel oral and dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Preferentially selects for JAK inhibitors (JAK1 and JAK3 primarily), preventing cytokine mediated signaling and functional responses varying cell types. Potential anti-cancer agent.
Biological Activity
cerdulatinib (prt062070) is a potent and selective inhibitor of syk and jak.[1]the jak/stat cascade, which has been implicated in hematopoiesis and cytokine signaling, is present in humans and flies. worms. the syk/zap70 kinases play an important role in human t and b cell signaling.[3]cerdulatinib can induce apoptosis via down-regulation of mcl1 protein and parp cleavage. through the inhibition of rb phosphorylation and down-regulation of cyclin e,the cerdulatinib can also block g1/s transition and cause cell cycle arrest. further analyses of the cell signaling activities showed that stat3 phosphorylation was sensitive to inhibition by cerdulatinib in abc cell lines while phosphorylation of syk, plcg2, akt and erk is reported to be sensitive to inhibition by cerdulatinib in gcb cell lines.[2]cerdulatinib is effective in rodent models of b-cell lymphoma and autoimmune disease and has exhibited anti-tumor activity in genetically diverse b-cell lymphoma cell lines and is more effective than syk- or jak- selective inhibitors alone.[1]
References
[1] manish patel , pau hamlin, md, etal. , a phase i open-label, multi-dose escalation study of the dual syk/jak inhibitor prt062070 (cerdulatinib) in patients with relapsed/refractory b cell malignancies. blood: 124 (21) ; december 6, 2014.
[2] y. lynn wang, md phd, jiao ma, phd, etal., syk and stat3 are active in diffuse large b-cell lymphoma: activity of cerdulatinib, a dual syk/jak inhibitor. blood: 124 (21) ; december 6, 2014.
[3]morrison dk, murakami ms, cleghon v. protein kinases and phosphatases in the drosophila genome. j cell biol. 2000 jul 24;150(2):f57-62.
Cerdulatinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 | lixing@pharmahuici.com | China | 133 | 58 |
View Lastest Price from Cerdulatinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Cerdulatinib
1198300-79-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Cerdulatinib
1198300-79-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-03-06 | Cerdulatinib
1198300-79-6
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- Cerdulatinib
1198300-79-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cerdulatinib
1198300-79-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cerdulatinib
1198300-79-6
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co