ChemicalBook >> CAS DataBase List >>BRD73954
BRD73954
- CAS No.
- 1440209-96-0
- Chemical Name:
- BRD73954
- Synonyms
- CS-1777;BRD73954;BRD-73954;BRD 73954;N1-hydroxy-N3-phenethylisophthalamide;N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide;1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-;BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide;N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954
- CBNumber:
- CB82730826
- Molecular Formula:
- C16H16N2O3
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD26383435
- MOL File:
- 1440209-96-0.mol
Last updated:2023-06-30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
BRD73954 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1361 | BRD73954 ≥98% (HPLC) | 1440209-96-0 | 5MG | $129 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML1361 | BRD73954 ≥98% (HPLC) | 1440209-96-0 | 25MG | $513 | 2022-05-15 | Buy |
| Cayman Chemical | 16919 | BRD73954 ≥95% | 1440209-96-0 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16919 | BRD73954 ≥95% | 1440209-96-0 | 5mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 16919 | BRD73954 ≥95% | 1440209-96-0 | 10mg | $632 | 2024-03-01 | Buy |
BRD73954 Chemical Properties,Uses,Production
Description
BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 μM, respectively). BRD73954 (10 μM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.
Uses
BRD73954 is a small molecule inhibitor which has the ability to inhibit HDAC6 and HDAC8. Affects cell adhesion and mobility in cells.
storage
Store at +4°C
References
[1]. olson de, wagner ff, kaya t, et al. discovery of the first histone deacetylase 6/8 dual inhibitors. j med chem, 2013, 56(11): 4816-4820.
BRD73954 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 80)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
BRD73954
N1-hydroxy-N3-phenethylisophthalamide
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954
BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide
BRD-73954;BRD 73954
CS-1777
1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-
1440209-96-0
Inhibitors