IWP 4
- CAS No.
- 686772-17-8
- Chemical Name:
- IWP 4
- Synonyms
- IWP 4;CS-2394;IWP4;IWP 4;IWP-4 >=95% (HPLC);Wnt Inhibitor IWP-4;Inhibitor of Wnt Production-4;IWP-4,inhibit,IWP 4,Inhibitor,Wnt,IWP4;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-;2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- CBNumber:
- CB82748092
- Molecular Formula:
- C23H20N4O3S3
- Molecular Weight:
- 496.62
- MDL Number:
- MFCD04457754
- MOL File:
- 686772-17-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
IWP 4 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1114 | IWP-4 ≥95% (HPLC) | 686772-17-8 | 5MG | $216 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1114 | IWP-4 ≥95% (HPLC) | 686772-17-8 | 25MG | $823 | 2024-03-01 | Buy |
| Cayman Chemical | 13954 | IWP-4 ≥95% | 686772-17-8 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 13954 | IWP-4 ≥95% | 686772-17-8 | 5mg | $145 | 2024-03-01 | Buy |
| Cayman Chemical | 13954 | IWP-4 ≥95% | 686772-17-8 | 10mg | $223 | 2024-03-01 | Buy |
IWP 4 Chemical Properties,Uses,Production
Uses
IWP 4 is a Porcn inhibitor.
Biological Activity
iwp 4 is an inhibitor of wnt production. iwp 4 impairs wnt pathway activity (ic50 = 25 nm) by inactivating porcupine, a membrane-bound acyltransferase responsible for attaching a palmitoyl group to wnt proteins, which is essential to wnt signaling and wnt secretion. the wnt family of signaling proteins is involved in most aspects of embryonic development and postembryonic tissue homeostasis. hyperactivation of the wnt/β-catenin pathway induces premature senescence of stem cells and age-related loss of stem cell function. in cancer, hyperactivation of the wnt/β-catenin pathway often exists along with mutations in other cell growth regulatory genes, which results in aberrant cell growth. thus, iwp 4 could serve a useful tool for researching tissue regeneration and wnt ligand-dependent tumors. iwp 4 has been used for inducing cardiomyocyte differentiation from human pluripotent stem cells.1. chen b, dodge me, tang w, et al. small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. nature chemical biology, 2009, 5(2): 100-107.2. lian x, hsiao c, wilson g, et al. robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical wnt signaling. proceedings of the national academy of sciences of the united states of america, 2012, 109(27): e1848-1857.
Biochem/physiol Actions
IWP-4 blocks Wnt family member 5a. It blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways.
storage
Store at +4°C
IWP 4 Preparation Products And Raw materials
Raw materials
Preparation Products
IWP 4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 | order@changyanchem.com | China | 5008 | 55 |