ChemicalBook
Chinese Japanese Germany

Indole

description Content analysis Toxicity Utilization limitation Chemical property Uses
Indole
Indole
CAS No.
120-72-9
Chemical Name:
Indole
Synonyms
Indol;INDOLE;Ketole;Benzaole;1H-Indol;IndoleGr;NSC 1964;1H-INDOLE;FEMA 2593;Benzazole
CBNumber:
CB8275772
Molecular Formula:
C8H7N
Formula Weight:
117.15
MOL File:
120-72-9.mol

Indole Properties

Melting point:
51-54 °C(lit.)
Boiling point:
253-254 °C(lit.)
Density 
1.22
FEMA 
2593 | INDOLE
refractive index 
1.6300
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
methanol: 0.1 g/mL, clear
form 
Crystalline Powder
color 
White to slightly pink
PH
5.9 (1000g/l, H2O, 20℃)
Water Solubility 
2.80 g/L (25 ºC)
Sensitive 
Light Sensitive
Merck 
14,4963
BRN 
107693
Stability:
Stable, but may be light or air sensitive. Incompatible with strong oxidizing agents, iron and iron salts.
CAS DataBase Reference
120-72-9(CAS DataBase Reference)
NIST Chemistry Reference
Indole(120-72-9)
EPA Substance Registry System
1H-Indole(120-72-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N,T
Risk Statements  21/22-37/38-41-50/53-36-39/23/24/25-23/24/25-52/53
Safety Statements  26-36/37/39-60-61-45-36/37
RIDADR  UN 2811 6.1/PG 3
WGK Germany  1
RTECS  NL2450000
8-13
TSCA  Yes
HazardClass  9
PackingGroup  III
Hazardous Substances Data 120-72-9(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1 g/kg (Smyth)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Indole price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 442619 Indole analytical standard 120-72-9 1EA $20.8 2017-11-08 Buy
Sigma-Aldrich 48157 Indole solution 120-72-9 1EA $35.3 2017-11-08 Buy
TCI Chemical I0021 Indole >99.0%(GC) 120-72-9 25g $21 2017-11-08 Buy
TCI Chemical I0021 Indole >99.0%(GC) 120-72-9 100g $56 2017-11-08 Buy
Alfa Aesar A14427 Indole, 99% 120-72-9 250g $118 2018-11-13 Buy

Indole Chemical Properties,Uses,Production

description

Indole, also called Benzopyrrole, an aromatic heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. It can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal smell. This off flavour occurs in beer due to contaminant coliform bacteria during the primary fermentation stage of beer brewing. At very low concentrations, however, it has a flowery smell, and is a constituent of many flower scents (such as orange blossoms) and perfumes. Natural jasmine oil, used in the perfume industry, contains around 2.5% of indole. Indole also occurs in coal tar. The participation of the nitrogen lone electron pair in the aromatic ring means that indole is not a base, and it does not behave like a simple amine.
Indoles are important precursors for other substances made within the human body and are, therefore, researched and used in lifestyle and medical applications. The compound was officially discovered in 1866 by a scientist working with the properties of zinc dust who reduced oxindole from the zinc dust into an indole. After the discovery, indoles became important constituents of the textile industry, and as more research was conducted, the larger role that indoles played within the human body system was realized. The indolic nucleus in substances like tryptophan and auxin has led to a better understanding of their mechanism within the body.

Content analysis

Press GT-10-4 gas chromatography method for the determination with polar column.
Using the polar column method in GT-10-4 gas chromatography to determine the content of indole.

Toxicity

GRAS(FEMA)。
LD50 1000 mg/kg(test with rat orally).

Utilization limitation

FEMAmg/kg:soft drinks:0.26;cold drinks:0.28;candy:0.50;bakery product :0.58;pudding:0.02~0.40.
Moderate limit (FDA§172.515,2000)

Chemical property

It is the shiny flaky white crystals, and would turn into dark colors when it exposed to light. There would be a strong unpleasant odor with high concentration of indole, but the flavor would change into oranges and jasmine after highly diluted (concentration <0.1%). It has the melting point of 52~53 ℃ and the boiling point of 253~254 ℃. It is soluble in alcohol, ether, hot water, propylene glycol, petroleum ether and most of the non-volatile oil, insoluble in glycerin and mineral oil.
Natural indole are widely contained in neroli oil, orange oil, lemon oil, lime oil, citrus oil, peel oil, jasmine oil and other essential oil.

Uses

(1) According to the GB 27 60-96 , indole can be used as flavouring agent and mainly used for preparing the essence of cheese, citrus, coffee, nuts, grape, strawberry, raspberry, chocolate, assorted fruit, jasmine and lily etc.
(2) It can be used as the reagent for the determination of nitrite, can also used in the manufacture of perfume and medicine.
(3) It can be used as the raw material of perfume, pharmaceuticals and plant growth hormone.
(4) Indole is the intermediate for the indole acetic acid and indole butyric acid.The indole acetic acid and indole butyric are plant growth regulator.
(5) It can be widely used in the manufacture of the essences of jasmine, lilac, orange blossom, gardenia, honeysuckle, lotus, narcissus, ylang, orchid and prynne etc. It is usually combined with the methyl indole to imitate the artificial civet. The extremely few of the indole can be used in chocolate, raspberry, strawberry, bitter orange, coffee, nuts, cheese, grapes and fruit and other fruity essential oil.
(6) Indole is mainly used as spices, dyes, amino acids and the raw materials of pesticide. Indole itself is a spice commonly used in producing the essences of jasmine, lilac, lotus flowers, orchids and other flower flavor. The usage is generally in a few thousandths.
(7) It can be used for verifying the gold, potassium and nitrite and manufacturing jasmine-type fragrance. It can also be used in pharmaceutical industry.

Chemical Properties

white crystals with an unpleasant odour

Uses

Can be used in perfumes and in the synthesis of tryptophan.

Uses

In highly dil solutions the odor is pleasant, hence indole has been used in perfumery.

Purification Methods

It can be further purified by sublimation in a vacuum or by zone melting. The picrate forms orange crystals from EtOH and has m 175o. [Beilstein 20 II 196, 20 III/IV 3176, 20/7 V 5.]

Indole Preparation Products And Raw materials

Raw materials

Preparation Products


Indole Suppliers

Global( 385)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 887 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22119 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10011 58
Hangzhou QiFei Chemical Co., Ltd. 0571-28950939 18058801870
0571-28950939 hzqifeihuagong@163.com China 42 55
Creasyn Finechem(Tianjin) Co., Ltd. 86-22-83945878,83945171,83945172
4008266163-06019 export@creasyn.com sale@creasyn.com China 897 68
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Indole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-23 Indole
120-72-9
US $3500.00 / KG 25KG 99.5% 50tons

120-72-9(Indole)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved