PROTOPINE HYDROCHLORIDE
- CAS No.
- 6164-47-2
- Chemical Name:
- PROTOPINE HYDROCHLORIDE
- Synonyms
- Nsc11440;FUMARINE;MACLEYINE;PROTOPINE HCL;PROTOHYPERICIN(RG);Argemonine (protopine;FUMARINE HYDROCHLORIDE;PROTOPINE HYDROCHLORIDE;13a-secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)-hydrochloride;7,13A-Secoberbin-13A-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride
- CBNumber:
- CB8276092
- Molecular Formula:
- C20H20ClNO5
- Molecular Weight:
- 389.83
- MDL Number:
- MFCD00236406
- MOL File:
- 6164-47-2.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | solid |
| FDA UNII | 96481YJ70G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UL2000000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
PROTOPINE HYDROCHLORIDE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P8489 | Protopine hydrochloride ≥98%, solid | 6164-47-2 | 5mg | $454 | 2024-03-01 | Buy |
| Cayman Chemical | 23366 | Protopine (hydrochloride) ≥98% | 6164-47-2 | 500μg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 23366 | Protopine (hydrochloride) ≥98% | 6164-47-2 | 1mg | $166 | 2024-03-01 | Buy |
| AK Scientific | 8223AH | Protopine hydrochloride | 6164-47-2 | 1mg | $282 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HBL0000189 | PROTOPINE HYDROCHLORIDE 95.00% | 6164-47-2 | 5MG | $910.32 | 2021-12-16 | Buy |
PROTOPINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities. It inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma at a concentration of 100 μM. Protopine inhibits contraction of isolated rat thoracic aorta induced by norepinephrine and is a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes. Protopine inhibits the growth of H. pylori with an MIC50 value of 100 μg/ml. It reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest. Protopine (0.005 mg/kg) increases latency to first seizure in a mouse model induced by pentylenetetrazole .
Uses
Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.
General Description
Protopine is a celandine alkaloid and a bioactive compound associated with the plant families including fumariaceae, berberidaceae?and papaveraceae. It is metabolized by demethylenation in the presence of the cytochrome enzymes cytochrome P450 family 2 subfamily d polypeptide 1 (CYP2D1) and cytochrome P450 family 2 subfamily c polypeptide 11 (CYP2C11).
Biochem/physiol Actions
Protopine possesses anti-parasitic, antimicrobial and anti-inflammatory property. It mediates mitotic arrest by favoring tubulin polymerization. Protopine elicits anti-invasive effects in breast cancer tumor progression.. It also provides protection against oxidative stress-induced cell death.
PROTOPINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PROTOPINE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1469 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7893 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |