D-1-N-Boc-prolinamide
- CAS No.
- 35150-07-3
- Chemical Name:
- D-1-N-Boc-prolinamide
- Synonyms
- BOC-PRO-NH2;1-Boc-D-proL;BOC-L-PRO-NH2;BOC-PYRD(2)-NH2;Boc-Proliniamide;BOC-L-PROLINAMIDE;Boc-D-Prolinamide;N-Boc-Prolinamide;BOC-D-PROLINEAMIDE;BOC-L-PROLINE AMIDE
- CBNumber:
- CB8284602
- Molecular Formula:
- C10H18N2O3
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD00190827
- MOL File:
- 35150-07-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Boc-L-prolinamide 97% | 661198 | 1g | $69.5 |
| 1-Boc-L-prolinamide 97% | 661198 | 5g | $323 |
| N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N) | B3756 | 1g | $24 |
| N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N) | B3756 | 5g | $31 |
| L-1-N-BOC-PROLIDINAMIDE 97% | B56853 | 100G | $38 |
| More product size | |||
| Melting point | 104-108 °C |
|---|---|
| Boiling point | 370.1±31.0 °C(Predicted) |
| Density | 1.155±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 15.97±0.20(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| optical activity | Consistent with structure |
| Major Application | peptide synthesis |
| InChI | 1S/C10H18N2O3/c1-10(2,3)15-9(14)12-6-4-5-7(12)8(11)13/h7H,4-6H2,1-3H3,(H2,11,13)/t7-/m0/s1 |
| InChIKey | PITJAAIPVBVRAO-ZETCQYMHSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCC[C@H]1C(N)=O |
| CAS DataBase Reference | 35150-07-3(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 2933.99.9701 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
D-1-N-Boc-prolinamide price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 661198 | 1-Boc-L-prolinamide 97% | 35150-07-3 | 1g | $69.5 | 2023-06-20 | Buy |
| Sigma-Aldrich | 661198 | 1-Boc-L-prolinamide 97% | 35150-07-3 | 5g | $323 | 2023-06-20 | Buy |
| TCI Chemical | B3756 | N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N) | 35150-07-3 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | B3756 | N-(tert-Butoxycarbonyl)-L-prolinamide >98.0%(HPLC)(N) | 35150-07-3 | 5g | $31 | 2026-04-30 | Buy |
| AstaTech | B56853 | L-1-N-BOC-PROLIDINAMIDE 97% | 35150-07-3 | 100G | $38 | 2026-04-30 | Buy |
D-1-N-Boc-prolinamide Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
1-Boc-L-prolinamide is a reagent that is used in the preparation of thiazole amide peptidomimetics as erratum inhibitor apoptosis protein antagonist.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
15761-39-4
35150-07-3
GENERAL METHOD: BOC-L-proline (1.00 g, 4.65 mmol), di-tert-butyl dicarbonate (1.52 g, 6.97 mmol), ammonium bicarbonate (0.55 g, 6.97 mmol), and pyridine (1.0 mL) were dissolved in dioxane (20 mL), and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, the product was extracted with dichloromethane, the organic phase was washed sequentially with 1 M hydrochloric acid and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the concentrate was added n-hexane (100 mL) and sonication prompted the product to precipitate as a white solid to afford N-tert-butoxycarbonyl-L-prolinamide (0.85 g, 85% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.37-4.34 (m, 1H), 3.47-3.36 (m, 2H), 2.07-1.85 (m, 4H), 1.49 (s, 9H). Mass spectrum (ESI) m/z 215 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 6, p. 1719 - 1729
[2] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[3] Journal of Agricultural and Food Chemistry, 2012, vol. 60, # 35, p. 8544 - 8551
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 228 - 247
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 23, p. 7418 - 7429
D-1-N-Boc-prolinamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from D-1-N-Boc-prolinamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | D-1-N-Boc-prolinamide
35150-07-3
|
US $100.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
-
- D-1-N-Boc-prolinamide
35150-07-3
- US $100.00 / KG
- 99%
- Career Henan Chemical Co
