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Naringin

Naringin
Naringin structure
CAS No.
10236-47-2
Chemical Name:
Naringin
Synonyms
ringin;Naring;NARINGIN;FEMA 2769;in hydrate;naringoside;Naringin,97%;Naringin CRS;(2S)-Naringin;ISOHESPERIDIN
CBNumber:
CB8288064
Molecular Formula:
C27H32O14
Formula Weight:
580.53
MOL File:
10236-47-2.mol

Naringin Properties

Melting point:
166 °C
alpha 
-91 º (c=1, C2H5OH)
Boiling point:
559.35°C (rough estimate)
Density 
1.3285 (rough estimate)
FEMA 
2769 | NARINGEN EXTRACT (CITRUS PARADISI MACF.)
refractive index 
-84 ° (C=2, EtOH)
storage temp. 
2-8°C
pka
7.17±0.40(Predicted)
form 
crystalline
color 
off-white
optical activity
[α]20/D 80±10°, c = 1% in ethanol
Water Solubility 
Soluble in water, alcohol, acetone and warm acetic acid.
Merck 
14,6425
BRN 
102012
CAS DataBase Reference
10236-47-2(CAS DataBase Reference)
FDA 21 CFR
182.20; 582.20
EWG's Food Scores
1
FDA UNII
N7TD9J649B
EPA Substance Registry System
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)- (10236-47-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  QN6340000
3
TSCA  Yes
HS Code  29389090
NFPA 704
0
1 0

Naringin price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 71162 Naringin ≥95% (HPLC) 10236-47-2 25g $53.2 2021-03-22 Buy
Sigma-Aldrich 71162 Naringin ≥95% (HPLC) 10236-47-2 100g $187 2021-03-22 Buy
Sigma-Aldrich Y0001378 Naringin European Pharmacopoeia (EP) Reference Standard 10236-47-2 $190 2021-03-22 Buy
TCI Chemical N0073 Naringin Hydrate >90.0%(T) 10236-47-2 25g $37 2021-03-22 Buy
Alfa Aesar J63166 Naringin 10236-47-2 25g $34.4 2021-03-22 Buy

Naringin Chemical Properties,Uses,Production

Description

Naringin is also called naringoside, hesperidin, and isohesperidin. It is a pale yellow flavanone compound extracted from immature or nearly mature outer layer of C. paradisi Macfad which belongs to Citrus grandis (L.) Osbeck. It tastes bitter and is naturally existed in the skin and flesh of Rutaceae like grapefruit, mandarin orange, and orange. It is also one of the active ingredients in many traditional Chinese medi cines like Rhizoma Drynariae, Immature Bitter Orange, Fructus Aurantii, and Exocarpium Citri Grandis. The contents of naringin in different plants vary greatly with the category and origin, and the content of naringin is high in immature fruits . In terms of traditional Chinese medicine, the flavor of grapefruit is sweet and sour, and the nature is cold; the flavors of its peel are sweet, pungent, and bitter, and the nature of its peel is warm. Both the pulp and the peel of grapefruit have the bio logical function including reducing phlegm, helping digestion, relieving abdominal distention, and fast diaphragm. And they are mainly used for the treatment of cough with asthma, sense of suppression in the chest, coldness and pain in abdomen, dys peptic retention, and hernia.

Chemical Properties

beige to yellowish powder

Physical properties

Appearance: white to light yellow crystalline powder. Solubility: soluble in metha nol, ethanol, acetone, acetic acid, dilute alkali solution, and hot water and insoluble in nonpolar solvent like petroleum benzin, ether, benzene, and chloroform. Melting

History

Naringin is mainly existed in the peel of grapefruit, lime, and their varieties; it has multiple biological activities and is widely applied in the fields of medicine, food, and cosmetics. In the 1930s, Harvey and Rygg obtained naringin through the method of isolation and extraction. They also established a colorimetric method for the determination of naringin, which laid the foundation for the following researches . Booth and other researchers conducted the systematic researches on the narin gin metabolites . In the 1960s, Hagen and other researchers established a fluores cence chromatography method for the determination naringin . In addition, the biological activity of naringin was evaluated. It was observed to improve ascites, experimental pulmonary edema, peritonitis, and oxygenation . At present, the extraction methods of naringin are hot water extraction, alkali extraction, and acid precipitation and organic solvent extraction. A series of pharmacological activity studies have been conducted and demonstrated its various biological activities .

Uses

antihaemorrhagic, antiinflammatory

Definition

ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosi ic linkage.

Pharmacology

Analgesic and Anti-inflammatory Effects
The writhing times of mice were found to be significantly reduced after intragastric administration of naringin at the dose of 60, 120, and 180 mg/kg. The swelling degree of ear was inhibited after intragastric administration of naringin at the dose of 120, 180, and 240 mg/kg. The peritoneal exudate was significantly reduced after intragastric administration of naringin at the dose of 120, 180, and 240 mg/kg. The inflammatory swelling caused by rat paw injection of protein was inhibited after intragastric administration of naringin at the dose of 60, 120, and 180 mg/kg/day for consecutive 3 days, and the anti-inflammatory mechanism may be related to the inhibitory effects on the process of synthesizing or releasing of inflammatory medi ators PGE2
Anti-apoptosis, Anti-radiation, and Cancer Prevention
Naringin was found to inhibit the liver damage caused by TNF releasing induced by lipopolysaccharide, which may be used to reduce the damage to liver and the inci dence of liver cancer . The anticancer effect of naringin was a comprehensive result caused by many physiological activities, including the effect of antioxidantand anti-free radicals, inhibiting the proliferation of cancer cells, inducing the apop tosis of tumor cells, and inhibiting the expression of cancer gene, among which inducing tumor cell apoptosis was an important way of naringin to prevent cancer
Protective Effects on Early Diabetes and Complications
Naringin was reported to promote the decomposition of sugar in the liver and decrease glycogen concentration by inhibiting the apoptosis of pancreatic B cells caused by oxidation and regulating the expressing and activity of fatty acid, choles terol, and glucose metabolism enzyme .
Naringin is the important component of traditional Chinese medicine drynaria rhizome. Experiment results have proved that naringin can inhibit many kinds of inflammation effects including osteoarthritis. Besides, naringin was found to have the effects of promoting osteoblast proliferation and differentiation as well as inhib iting the activity of osteoclast

Clinical Use

It was used for the treatment of bacterial infection, calm, and cancer prevention

Purification Methods

This bitter principle from grape juice crystallises from water to give the hydrate with 6-8 H2O which when dried at 110o gives the dihydrate. Its solubility in H2O is 0.1% at 40o and 10% at 75o. The 2,4-dinitrophenylhydrazone crystallises from aqueous dioxane with m 246-247o [Douglass et al. J Am Chem Soc 73 4023 1951]. [Pulley & von Loesecke J Am Chem Soc 61 175 1939, Beilstein 18 III/IV 2637, 18 V 528.]

Naringin Preparation Products And Raw materials

Raw materials

Preparation Products


Naringin Suppliers

Global( 432)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5450 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58

View Lastest Price from Naringin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-26 Naringin 10236-47-2
10236-47-2
US $12.50 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-31 Naringin
10236-47-2
US $10.00 / KG 1KG 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-07-30 naringin
10236-47-2
US $60.00 / KG 1KG 98% 100kg Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.

Naringin Spectrum


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