Cytochrome P450, purified, soluble

CAS No.
Chemical Name:
Cytochrome P450, purified, soluble
Synonyms
CYP2C9;CYP2C10;CYP2C9 R144C;CYP2C9 I359L;CYP2C19 I331V;CYP2C9 Il359Leu;CYP2C9 Arg144Cys;CYP2C19 Ile331Val;Cytochrome P450 2C19 I331V, human;Cytochrome P450, purified, soluble
CBNumber:
CB82881766
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Cytochrome P450, purified, soluble Properties

Flash point 160 °C
storage temp. -70°C

SAFETY

Risk and Safety Statements

WGK Germany  3

Cytochrome P450, purified, soluble price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB1305083 MONOCLONAL ANTI-CYP2C9 (N-TERMINAL) antibody produced in mouse crude ascites, buffered aqueous solution 100μL $495 2024-03-01 Buy
Usbiological 355144 CYP2C9 48Tests $588 2021-12-16 Buy
Biorbyt Ltd orb595949 CYP2C9 10μg $290.7 2021-12-16 Buy
Product number Packaging Price Buy
SAB1305083 100μL $495 Buy
355144 48Tests $588 Buy
orb595949 10μg $290.7 Buy

Cytochrome P450, purified, soluble Chemical Properties,Uses,Production

Description

The CYP2C9 and CYP2C19 are the main isoforms for the metabolism of the antiseizure drug phenytoin and for the anticoagulant S-warfarin. Although CYP2C19 metabolizes fewer drugs than CYP2D6 does, the drugs CYP2C19 does metabolize are clinically important (Table 10.6). Deficit of CYP2C19 is found in the PM phenotype, which is only seen in 8 to 13% of Caucasians, 20 to 30% of the Asian population (11–23% of Japanese and 5–37% of Chinese), up to 20% of the black African-American population, 14 to 15% of Saudi Arabians and Ethiopians, and up to 70% of Pacific Islanders. The more common mutant allele in these individuals is CYP2C19*2, which expresses an inactive enzyme. The large interindividual variability observed in the therapeutic response to the antiseizure drug mephenytoin is attributed to CYP2C19 polymorphism, which catalyzes the p-hydroxylation of its S-stereoisomer. The R-enantiomer is N-demethylated by CYP2C8 with no difference in its metabolism between PMs and EMs.
The CYP2C9 is the primary isoform for the metabolism of the antiseizure drug phenytoin, the anticoagulant S-warfarin, and the hypoglycemic drug tolbutamide. Other clinically important drugs are listed in Table 10.6. At least six different mutant CYP2C9 alleles have been identified; of these, the two alleles primarily responsible for CYP2C9 deficiency are CYP2C9*2 and CYP2C9*3 and code for enzymes with reduced affinity for substrates. A deficiency of this isoform, however, is seen in 8 to 13% of Caucasians, 2 to 3% of African Americans, and 1% of the Asians. Individuals with the PM phenotype who possess this deficient isoform variant are ineffective in clearing S-warfarin (so much so that they may be fully anticoagulated on just 0.5 mg of warfarin per day) and in the clearance of phenytoin, which has a potentially very toxic narrow therapeutic range. On the other hand, the pro-drug losartan will be poorly activated and ineffective.

Cytochrome P450, purified, soluble Preparation Products And Raw materials

Raw materials

Preparation Products

Cytochrome P450, purified, soluble Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749 sales@shzbio.com China 9966 58
CYP2C9 Cytochrome P450 2C9*1 (Wild type allele), human MONOCLONAL ANTI-CYP2C9 (N-TERMINAL) antibody produced in mouse ANTI-CYP2C9 (N-TERM) antibody produced in rabbit ANTI-CYP2C9 (CENTER) antibody produced in rabbit CYP2C10 CYP2C9 Arg144Cys CYP2C9 R144C Cytochrome P450 2C9*2 (R144C), human CYP2C9 I359L CYP2C9 Il359Leu Cytochrome P450 2C9*3 (I359L), human Cytochrome P450, purified, soluble CYP2C19 I331V CYP2C19 Ile331Val Cytochrome P450 2C19 I331V, human