2-Benzofurancarboxaldehyde
- CAS No.
- 4265-16-1
- Chemical Name:
- 2-Benzofurancarboxaldehyde
- Synonyms
- Coumarilaldehyde;BUTTPARK 98\04-15;2-Formylbenzofuran;RARECHEM AM LA 0016;TIMTEC-BB SBB010059;2-BENZOFURAN ALDEHYDE;2-formylbenzo[b]furan;2-BENZOFURANCARBALDEHYDE;BENZOFURAN-2-CARBALDEHYDE;2-BENZOFURANCARBOXALDEHYDE
- CBNumber:
- CB8288271
- Molecular Formula:
- C9H6O2
- Molecular Weight:
- 146.14
- MDL Number:
- MFCD00015463
- MOL File:
- 4265-16-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Benzofurancarboxaldehyde 97% | 493449 | 1g | $71.33 |
| 2-Benzofurancarboxaldehyde 97% | 493449 | 5g | $158.2 |
| Benzofuran-2-carbaldehyde min. 98.0 % | B5282 | 1G | $57 |
| Benzofuran-2-carbaldehyde min. 98.0 % | B5282 | 5G | $171 |
| 2-Benzofurancarboxaldehyde | 159411 | 1g | $460 |
| More product size | |||
| Melting point | 9-9.5 °C |
|---|---|
| Boiling point | 135 °C18 mm Hg(lit.) |
| Density | 1.206 g/mL at 25 °C(lit.) |
| refractive index |
n |
| FEMA | 3128 | 2-BENZOFURANCARBOXALDEHYDE |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| Specific Gravity | 1.206 |
| color | Clear yellow to brown |
| Odor | at 100.00 %. bitter almond |
| Odor Type | fruity |
| Water Solubility | Not miscible or difficult to mix with water. |
| Sensitive | Air Sensitive |
| JECFA Number | 751 |
| BRN | 2910 |
| InChI | 1S/C9H6O2/c10-6-8-5-7-3-1-2-4-9(7)11-8/h1-6H |
| InChIKey | ADDZHRRCUWNSCS-UHFFFAOYSA-N |
| SMILES | O=Cc1cc2ccccc2o1 |
| LogP | 2.09 |
| CAS DataBase Reference | 4265-16-1(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 2-BENZOFURANCARBOXALDEHYDE |
| FDA UNII | DGQ01SIT6T |
| NIST Chemistry Reference | Benzofuran-2-carboxaldehyde(4265-16-1) |
| EPA Substance Registry System | 2-Benzofurancarboxaldehyde (4265-16-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
2-Benzofurancarboxaldehyde price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 493449 | 2-Benzofurancarboxaldehyde 97% | 4265-16-1 | 1g | $71.33 | 2025-07-31 | Buy |
| Sigma-Aldrich | 493449 | 2-Benzofurancarboxaldehyde 97% | 4265-16-1 | 5g | $158.2 | 2025-07-31 | Buy |
| TCI Chemical | B5282 | Benzofuran-2-carbaldehyde min. 98.0 % | 4265-16-1 | 1G | $57 | 2025-07-31 | Buy |
| TCI Chemical | B5282 | Benzofuran-2-carbaldehyde min. 98.0 % | 4265-16-1 | 5G | $171 | 2025-07-31 | Buy |
| Usbiological | 159411 | 2-Benzofurancarboxaldehyde | 4265-16-1 | 1g | $460 | 2021-12-16 | Buy |
2-Benzofurancarboxaldehyde Chemical Properties,Uses,Production
Chemical Properties
2-Formyl benzofuran has a bitter almond odor.
Chemical Properties
Colorless to light yellow liqui
Uses
Benzo[b]furan-2-carboxaldehyde is used for the synthesis of isoxazolines.
Uses
2-Benzofurancarboxaldehyde may be used in the preparation of (E)-3-(benzofuran-2′-ylmethylidene)-1-methyl-2-indolinone and 1-(benzofuran-2-yl)methanol.
Definition
ChEBI: 2-Benzofurancarboxaldehyde is a member of benzofurans.
Preparation
By the Gattermann process; also from coumaryloyl cyanide.
General Description
2-Benzofurancarboxaldehyde, also known as benzo[b]-2-furfural, is an α,β-unsaturated aldehyde.
Synthesis
271-89-6
68-12-2
4265-16-1
General procedure for the synthesis of benzo[b]furan-2-carbaldehyde from 2,3-benzofuran and N,N-dimethylformamide: Triclosan (4.73 mL, 50.79 mmol) was slowly added to a solution of N,N-dimethylformamide (6.56 mL, 84.75 mmol) under conditions of keeping the temperature lower than 40 °C. Subsequently, 2,3-benzofuran (2.00 g, 16.93 mmol) was added dropwise to the reaction mixture over a period of 15 min under the same temperature conditions. The reaction mixture was heated up to 80 °C for 24 hours. After completion of the reaction, the mixture was carefully poured into ice water and neutralized with sodium hydroxide solution. The organic phase was separated and the aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with brine and dried over anhydrous magnesium sulfate. The filtrate was concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10:1) to afford benzo[b]furan-2-carbaldehyde (2.27 g, 90% yield) as a brown oil.1H NMR (400 MHz, CDCl3): δ 9.83 (1H, s, CHO), 7.75-7.70 (1H, m, H-4 ), 7.56-7.54 (2H, m, H-6,7), 7.46 (1H, s, H-3), 7.32-7.28 (1H, m, H-5).13C NMR (100 MHz, CDCl3): δ 179.63 (CHO), 156.03 (C-7a), 152.52 (C-2), 129.07 (C-3a) , 126.51 (C-6), 124.05 (C-5), 123.58 (C-4), 117.93 (C-3), 112.44 (C-7).
References
[1] Chemical Communications, 2017, vol. 53, # 54, p. 7545 - 7548
[2] Organic Letters, 2012, vol. 14, # 3, p. 844 - 847
[3] Letters in Drug Design and Discovery, 2014, vol. 11, # 8, p. 975 - 984
[4] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270
[5] Patent: WO2016/114816, 2016, A1. Location in patent: Paragraph 0331
2-Benzofurancarboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14343 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15080 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from 2-Benzofurancarboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-Benzofurancarboxaldehyde
4265-16-1
|
US $1.00 / kg | 1kg | 98% | 200KG | Career Henan Chemical Co |
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- 2-Benzofurancarboxaldehyde
4265-16-1
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
