MG-132, Ready Made Solution

CAS No.
Chemical Name:
MG-132, Ready Made Solution
Synonyms
MG-132, Ready Made Solution
CBNumber:
CB82886796
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

MG-132, Ready Made Solution Properties

Flash point 87 °C
storage temp. -20°C
form DMSO solution

SAFETY

Risk and Safety Statements

WGK Germany  2

MG-132, Ready Made Solution price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M7449 MG-132, Ready Made Solution ≥90% (HPLC) 200μL $92.3 2024-03-01 Buy
Sigma-Aldrich M7449 MG-132, Ready Made Solution ≥90% (HPLC) 1ml $303 2024-03-01 Buy
Product number Packaging Price Buy
M7449 200μL $92.3 Buy
M7449 1ml $303 Buy

MG-132, Ready Made Solution Chemical Properties,Uses,Production

Uses

MG-132, Ready Made Solution has been used to inhibit the proteasome in various systems, including:

  • hTERT-RPE1 and HeLa cells: Osorio-Zambrano, W.F. et al., PLoS One, 10(12), e0144434 (2015)
  • FaDu human hypopharynx cancer cells: Kim, S.-Y. et al., Autophagy, 14(3), 385-403 (2018)
  • HEK293 cells: Chen, Q. et al., Cell Reports, 22(11), 2860-2872 (2018).
  • Neonate rat cardiomyocytes: Turkieh, A. et al., Cell Death Dis., 10(8), 608 (2019)
  • Adult neural stem cells: Morrow, C.S. et al., Cell Stem Cell, 26(4), 558-568.e9 (2020).

General Description

MG132 is a potent proteasome inhibitor that also inhibits calpains and lysosomal cathepsins. One of the first proteasome inhibitors to be developed, MG-132 is widely used in proteasome inhibition studies because of its high potency, high selectivity, and rapid reversibility. MG132 mechanistically acts as a proteasome inhibitor by hemiacetal formation with hydroxyl groups of active site threnonine residues.

Biochem/physiol Actions

MG132, also known as carbobenzoxy-Leu-Leu-leucinal, is a peptide aldehyde which plays a vital role in the inhibition of proteolytic activity of the 26S proteasome complex. MG132 retards the growth of HeLa cells by promoting cell cycle arrest and apoptosis. Treatment of HepG2 and HeLa cells with MG-132 triggers increased expression of MCPIP1 mRNA, which in turn increases MCPIP1 protein concentration. MCPIP1 is implicated in negative regulation of macrophage activation and differentiation of several cell types, including pre-adipocytes, neuroprogenitor cells and osteoclast precursors. MG-132 stimulates dopamine reduction and nigral dopaminergic degeneration in both cell culture and animal models of Parkinson′s disease.

MG-132, Ready Made Solution Preparation Products And Raw materials

Raw materials

Preparation Products

MG-132, Ready Made Solution Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
MG-132, Ready Made Solution