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(+/-)-BUFURALOL HYDROCHLORIDE

CAS No.
59652-29-8
Chemical Name:
(+/-)-BUFURALOL HYDROCHLORIDE
Synonyms
ANGIUM;ro3-4787;AngiumHCl;Bufuralol HCl;bufurololhydrochloride;Bufuralol hudrochloride;BUFURALOL, HYDROCHLORIDE;(+/-)-BUFURALOL HYDROCHLORIDE;2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride;2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride
CBNumber:
CB8289344
Molecular Formula:
C16H24ClNO2
Molecular Weight:
297.82
MDL Number:
MFCD00272648
MOL File:
59652-29-8.mol
MSDS File:
SDS
Last updated:2023-05-09 09:30:52

(+/-)-BUFURALOL HYDROCHLORIDE Properties

Melting point 143-146 °C
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form Solid
color white to off-white
FDA UNII G66IY7Q7S4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
Toxicity LD50 in mice (mg/kg): 29.7 i.v.; 88.0 i.p.; 177 orally; in rats (mg/kg): 1400 s.c.; 750 orally (Hamilton, Parkes)

(+/-)-BUFURALOL HYDROCHLORIDE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Medical Isotopes, Inc. 7889 BufuralolHCl 59652-29-8 50mg $2000 2021-12-16 Buy
Product number Packaging Price Buy
7889 50mg $2000 Buy

(+/-)-BUFURALOL HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

Fine White Powder

Originator

Bururalol hydrochloride,Onbio Inc.

Uses

A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.

Uses

A -Adrenergic blocker with peripheral vasodilating activity

Manufacturing Process

68.3 g (0.182 mol) of trimethyl-phenyl-ammonium perbromide were added in a single portion at 20°C to a stirred solution of 48.5 g (0.182 mol) of 5- bromo-2-acetyl-7-ethylbenzofuran in 400 ml of dry tetrahydro-furan. The resulting mixture was stirred at 20°C for 3 h, during which time trimethylphenyl- ammonium bromide precipitated out. The mixture was then poured into water and extracted 3 times with ether. The combined ether extracts were washed successively with water, saturated sodium bicarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure. The solid residue was recrystallized from ethanol to yield 43.1 g of 5-bromo-2-bromoacetyl-7-ethylbenzofuran as yellow crystals, melting point 101-102°C.
1.35 g of sodium borohydride were added portion-wise at room temperature over a period of 20 min to a stirred solution of 17.3 g (0.05 mol) of 5-bromo- 2-bromoacetyl-7-ethylbenzofuran in 100 ml of dioxane and 25 ml of water.
The mixture was stirred at room temperature for 3 h, then dioxane was removed by evaporation at 40°C under reduced pressure and the residue was diluted with water and extracted 3 times with ether. The combined ether extracts were worked up in the usual manner to yield 16.0 g of crude 5- bromo-2-(2-bromo-1-hydroxyethyl)-7-ethyl-benzofuran as a viscous oil. 16.0 g of crude 5-bromo-2-(2-bromo-1-hydroxyethyl)-7-ethylbenzofuran and 37.0 g of t-butylamine were heated at 100°C in a sealed autoclave for 24 h. After cooling, excess t-butylamine was evaporated off and the residue was taken up in dilute aqueous hydrochloric acid. The aqueous solution was washed twice with ether, basified with dilute aqueous sodium hydroxide solution and extracted twice with ether. The combined ether extracts were washed with water and with brine, dried over anhydrous sodium sulfate, filtered and evaporated. The solid residue was crystallized from petroleum ether (boiling point 60-80°C) to yield 4.7 g of 5-bromo-2-(2-t-butylamino-1- hydroxyethyl)-7-ethylbenzofuran as buff crystals, melting point 101-103°C.
4.8 g of 5-bromo-2-(2-t-butylamino-1-hydroxyethyl)-7-ethylbenzofuran in 50 ml of ethanol were hydrogenated at room temperature and atmospheric pressure in the presence of 0.3 g of 5% palladium-on-carbon catalyst. After the uptake of one equivalent of hydrogen, the hydrogenation was terminated, catalyst was filtered off and the filtrate was evaporated to dryness. The residue was basified and extracted twice with ether. The combined ether extracts were worked up in the usual manner to give 2-(2-t-butylamino-1- hydroxyethyl)-7-ethylbenzofuran in the form of an oil. In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker

(+/-)-BUFURALOL HYDROCHLORIDE Preparation Products And Raw materials

(+/-)-BUFURALOL HYDROCHLORIDE Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Amadis Chemical Company Limited
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55477 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 17825480238 3008233717@qq.com China 9844 12
Jinan blalong chemical co. LTD 2710913286@.com 1513643261@qq.com China 14253 58
1-(7-aethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyaethan-hydrochlorid 1-(7-ethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyethanehydrochloride 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride bufurololhydrochloride ro3-4787 ANGIUM (+/-)-BUFURALOL HYDROCHLORIDE BUFURALOL, HYDROCHLORIDE ALPHA-[(TERT-BUTYLAMINO)METHYL]-7-ETHYL-2-BENZOFURANMETHANOL HYDROCHLORIDE AngiumHCl a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol α-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol 1-(7-Aethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyaethan-hydrochlorid [german] Bufuralol HCl Bufuralol hudrochloride 2-(tert-Butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol hydrochloride 59652-29-8 C16H23NO2HCl Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals