1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
![1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Structure](CAS/GIF/34823-86-4.gif)
- CAS No.
- 34823-86-4
- Chemical Name:
- 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
- Synonyms
- GTP-14564;3-PHENYL-1H-BENZOFURO[3,2-C]PYRAZOLE;1H-Benzofuro[3,2-c]pyrazole, 3-phenyl-;1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
- CBNumber:
- CB8298108
- Molecular Formula:
- C15H10N2O
- Molecular Weight:
- 234.25
- MDL Number:
- MFCD01416326
- MOL File:
- 34823-86-4.mol
| Melting point | 222-223 °C |
|---|---|
| Boiling point | 459.1±25.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 12.72±0.30(Predicted) |
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17543 | GTP 14564 ≥98% | 34823-86-4 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17543 | GTP 14564 ≥98% | 34823-86-4 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 17543 | GTP 14564 ≥98% | 34823-86-4 | 5mg | $139 | 2024-03-01 | Buy |
| Tocris | 2086 | GTP14564 ≥99%(HPLC) | 34823-86-4 | 10 | $122 | 2021-12-16 | Buy |
| TRC | G800505 | GTP14564 | 34823-86-4 | 1mg | $40 | 2021-12-16 | Buy |
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Chemical Properties,Uses,Production
Description
GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 μM for c-Fms, c-Kit, ITD-FLT3 and 1 μM for PDGFRβ). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.
Uses
GTP 14564 is a class III receptor tyrosine kinase (RTK) inhibitor.
Definition
ChEBI: 3-phenyl-1H-benzofuro[3,2-c]pyrazole is a member of pyrazoles and a ring assembly.
Biological Activity
Potent, selective inhibitor of class III receptor tyrosine kinases (IC 50 values are 0.3 μ M for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μ M for PDGFR β ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μ M). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic.
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Preparation Products And Raw materials
Raw materials
Preparation Products
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3412 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2987 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3538 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 3362556465@qq.com | China | 8000 | 58 |