Guaiazulene
- CAS No.
- 489-84-9
- Chemical Name:
- Guaiazulene
- Synonyms
- Azulene, 1,4-dimethyl-7-(1-methylethyl)-;Azulol;Guaiazulenum;Azunol;Guiazulene;7-ISOPROPYL-1,4-DIMETHYLAZULENE;AZ-8;AZULON;uaiazuL;Cuteazul
- CBNumber:
- CB8298946
- Molecular Formula:
- C15H18
- Molecular Weight:
- 198.3
- MDL Number:
- MFCD00003811
- MOL File:
- 489-84-9.mol
- MSDS File:
- SDS
| Melting point | 27-29 °C (lit.) |
|---|---|
| Boiling point | 153 °C/7 mmHg (lit.) |
| Density | 0.976 g/mL at 25 °C (lit.) |
| refractive index | 1.3166 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Sparingly) |
| form | Low Melting Crystalline Solid |
| color | Dark blue |
| Water Solubility | Soluble in alcohol, water, 0.1115 mg/L @ 25°C (est). |
| Merck | 14,4554 |
| BRN | 1365001 |
| LogP | 5.590 (est) |
| CAS DataBase Reference | 489-84-9(CAS DataBase Reference) |
| FDA 21 CFR | 73.2180 |
| EWG's Food Scores | 1-4 |
| FDA UNII | 2OZ1K9JKQC |
| NIST Chemistry Reference | Azulene, 1,4-dimethyl-7-(1-methylethyl)-(489-84-9) |
| EPA Substance Registry System | Azulene, 1,4-dimethyl-7-(1-methylethyl)- (489-84-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 36/37/39-26-22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CO4790000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2902190000 | |||||||||
| NFPA 704 |
|
Guaiazulene price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G11004 | Guaiazulene 99% | 489-84-9 | 10g | $83.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | G11004 | Guaiazulene 99% | 489-84-9 | 25g | $136 | 2024-03-01 | Buy |
| TCI Chemical | G0228 | Guaiazulene >99.0%(GC) | 489-84-9 | 10g | $70 | 2024-03-01 | Buy |
| Alfa Aesar | A17690 | Guaiazulene, 98+% | 489-84-9 | 5g | $33.65 | 2024-03-01 | Buy |
| Alfa Aesar | A17690 | Guaiazulene, 98+% | 489-84-9 | 25g | $108.65 | 2024-03-01 | Buy |
Guaiazulene Chemical Properties,Uses,Production
Chemical Properties
DARK BLUE LOW MELTING CRYSTALLINE SOLID
Originator
AZ 8,Millet Roux
Uses
Guaiazulene can be used as a starting material for the synthesis of:
- Azulene-based dye molecules such as 3-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanoacrylic acid and 5-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanopenta-2,4-dienoic acid.
- Stilbazulenyl nitrone, a second-generation azulenyl nitrone which can be used as a chain-breaking antioxidant.
- Bis-azulenyl based near-infrared fluorescence quencher.
Uses
antioxidant, inhibits lipid peroxidation inhibitor, antiinflammatory, hepatoprotectant; LD50(rat) 1550 mg/kg po
Definition
ChEBI: Guaiazulene is a sesquiterpene. It derives from a hydride of a guaiane.
Manufacturing Process
10 kg a gum of Guacum officinale was heated with 3-4 kg of sulfur to 130°C.
The heating was slowly continued for 220°C under the nitrogen. The formed
water steam was removed with the nitrogen current. The temperature should
be higher 100°C in order to the water didnt fall into reaction mixture. H2S was
obtained simultaneously the dehydrogenation and removed with water steam.
Hydrogen sulfide was connected in an alkaline trap.
When a H2S discharge stopped, the temperature was decreased to 120°C and
the reaction mixture was distilled in vacuum 1-20 mm. The distillate had deep
blue color and contained 6-7 kg oil with 20% of 7-isopropyl-1,4-
dimethylazulene. It was dissolved in the 5-10 volumes of light petroleum,
shook with sodium hydroxide for removing the sulfur containing substaneces,
washed to neutral. Then petrolem layer was mixed with 10-15 L 62% H2SO4
for removing the by-products, the petroleum layer lost the blue color and the
desired substance was in sulphuric acid layer. The last one was shook with ice
and NaOH. As a result about 7% NaSO4 solution in sulfuric acid was obtained.
It was diluted and azulene gave an emulsion, which was extracted with 10 L
of petrolem and distilled. The 7-isopropyl-1,4-dimethylazulene is distilled at
167°-168°C/12 mm. Yield 10-15%.
Therapeutic Function
Antiinflammatory
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Purification Methods
It forms blue-violet plates from EtOH. Also redistil it in vacuo until distillate solidifies. UV has max at 284nm (log 4.6, heptane). The picrate has m 122o(EtOH). [Beilstein 5 III 1677, 5 IV 1751.]
Guaiazulene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 269 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
View Lastest Price from Guaiazulene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-10 | Guaiazulene
489-84-9
|
US $620.00-420.00 / KG | 1KG | 99.9% up | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-04-01 | Guaiazulene
489-84-9
|
US $0.00-0.00 / kg | 20kg | 99% | 200000 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2023-09-18 | Guaiazulene
489-84-9
|
US $30.00-7.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Guaiazulene
489-84-9
- US $620.00-420.00 / KG
- 99.9% up
- Sinoway Industrial co., ltd.
-
- Guaiazulene
489-84-9
- US $0.00-0.00 / kg
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- Guaiazulene
489-84-9
- US $30.00-7.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.