ChemicalBook >> CAS DataBase List >>(R)-2-Flurbiprofen

(R)-2-Flurbiprofen

CAS No.
51543-40-9
Chemical Name:
(R)-2-Flurbiprofen
Synonyms
Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
CBNumber:
CB8302496
Molecular Formula:
C15H13FO2
Molecular Weight:
244.26
MDL Number:
MFCD00869714
MOL File:
51543-40-9.mol
MSDS File:
SDS
Last updated:2023-08-11 16:54:45

(R)-2-Flurbiprofen Properties

Melting point 110-113 °C(lit.)
Boiling point 376.2±30.0 °C(Predicted)
Density 1.199±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml
pka 4.14±0.10(Predicted)
form Crystalline Powder
color White to off-white
NCI Dictionary of Cancer Terms R-flurbiprofen
FDA UNII 501W00OOWA
NCI Drug Dictionary Flurizan

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  26-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29163900
NFPA 704
0
2 0

(R)-2-Flurbiprofen price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 100mg $32 2024-03-01 Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 1g $133 2024-03-01 Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 250mg $73 2024-03-01 Buy
Cayman Chemical 70255 (R)-Flurbiprofen ≥99% 51543-40-9 500mg $116 2024-03-01 Buy
TRC F598730 (R)-Flurbiprofen 51543-40-9 250mg $140 2021-12-16 Buy
Product number Packaging Price Buy
70255 100mg $32 Buy
70255 1g $133 Buy
70255 250mg $73 Buy
70255 500mg $116 Buy
F598730 250mg $140 Buy

(R)-2-Flurbiprofen Chemical Properties,Uses,Production

Description

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.

Uses

(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Definition

ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.

Biochem/physiol Actions

gamma secretase inhibitor; amyloid Abeta 42 lowering agent

(R)-2-Flurbiprofen Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 189)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 info@longyupharma.com China 2530 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290 1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10326 58

View Lastest Price from (R)-2-Flurbiprofen manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-2-Flurbiprofen pictures 2023-08-12 (R)-2-Flurbiprofen
51543-40-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
(R)-2-Flurbiprofen pictures 2023-03-29 (R)-2-Flurbiprofen
51543-40-9
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
(R)-2-Flurbiprofen pictures 2021-11-15 (R)-2-Flurbiprofen
51543-40-9
US $90.00 / KG 10KG 99.9% 100tons Qiuxian Baitai New Material Co., LTD

(R)-2-Flurbiprofen Spectrum

(R)-2-Fluoro-α-methyl-1,1'-biphenyl-4-acetic acid (R)-α-Methyl-2-fluoro-1,1'-biphenyl-4-acetic acid (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid (Flurbiprofe [1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-Methyl-,(aR)- MPC 7869 (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 97% (R)-Flurbiprofen, >=99% (R)-2-Flurbiprofenr (R)-2-FLUBIPROFEN (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (R)-(-)-FLURBIPROFEN E-7869 (R)-2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid Flurbiprofene (R)-(-)-2-Fluoro-α-methyl-4-biphenylacetic acid (R)-2-Flurbiprofen [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (R)- [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αR)-  l-Flurbiprofen (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (FLURBIPROFEN) (R)-2-Flurbiprofen, Tarenflurbil (R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propionic acid E7869,Tarenflurbil,MPC7869 (R)-Flurbiprofen (E7869 Flurbiprofen CRS (R)-FL Flurbiprofen (R)-Isomer (R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid (R)-2-Flurbiprofen USP/EP/BP (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic aci R- Flurbiprofen-d4 Flurizan (R)-FLURBIPROFEN Furbiprofen Tarenflurbil 2-Flurbiprofen (R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid (-)-Flurbiprofen 51543-40-9 1543-40-9 Organic Building Blocks Chiral Building Blocks Asymmetric Synthesis Carboxylic Acids API Pharmaceutical ingredients