(R)-2-Flurbiprofen
- CAS No.
- 51543-40-9
- Chemical Name:
- (R)-2-Flurbiprofen
- Synonyms
- Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
- CBNumber:
- CB8302496
- Molecular Formula:
- C15H13FO2
- Molecular Weight:
- 244.26
- MDL Number:
- MFCD00869714
- MOL File:
- 51543-40-9.mol
- MSDS File:
- SDS
Melting point | 110-113 °C(lit.) |
---|---|
Boiling point | 376.2±30.0 °C(Predicted) |
Density | 1.199±0.06 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml |
pka | 4.14±0.10(Predicted) |
form | Crystalline Powder |
color | White to off-white |
NCI Dictionary of Cancer Terms | R-flurbiprofen |
FDA UNII | 501W00OOWA |
NCI Drug Dictionary | Flurizan |
(R)-2-Flurbiprofen price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 70255 | (R)-Flurbiprofen ≥99% | 51543-40-9 | 100mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 70255 | (R)-Flurbiprofen ≥99% | 51543-40-9 | 1g | $133 | 2024-03-01 | Buy |
Cayman Chemical | 70255 | (R)-Flurbiprofen ≥99% | 51543-40-9 | 250mg | $73 | 2024-03-01 | Buy |
Cayman Chemical | 70255 | (R)-Flurbiprofen ≥99% | 51543-40-9 | 500mg | $116 | 2024-03-01 | Buy |
TRC | F598730 | (R)-Flurbiprofen | 51543-40-9 | 250mg | $140 | 2021-12-16 | Buy |
(R)-2-Flurbiprofen Chemical Properties,Uses,Production
Description
(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.
Uses
(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.
Definition
ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.
Biochem/physiol Actions
gamma secretase inhibitor; amyloid Abeta 42 lowering agent
(R)-2-Flurbiprofen Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12452 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2530 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3959 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17368 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from (R)-2-Flurbiprofen manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-08-12 | (R)-2-Flurbiprofen
51543-40-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2023-03-29 | (R)-2-Flurbiprofen
51543-40-9
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. | ||
2021-11-15 | (R)-2-Flurbiprofen
51543-40-9
|
US $90.00 / KG | 10KG | 99.9% | 100tons | Qiuxian Baitai New Material Co., LTD |
- (R)-2-Flurbiprofen
51543-40-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- (R)-2-Flurbiprofen
51543-40-9
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
- (R)-2-Flurbiprofen
51543-40-9
- US $90.00 / KG
- 99.9%
- Qiuxian Baitai New Material Co., LTD
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